ACO2

Description		aconitase 2
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	Aconitate Hydratase Activity Iron Ion Binding Lyase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Tricarboxylic Acid Cycle Citrate Metabolic Process
Pathways		Mitochondrial protein import Citric acid cycle (TCA cycle) Mitochondrial protein degradation Maturation of TCA enzymes and regulation of TCA cycle
Drugs		Isocitric Acid 4-Hydroxy-Aconitate Ion Alpha-Methylisocitric Acid Aconitate Ion Tricarballylic acid
Diseases
GWAS		Adult body size ( 32376654) Asthma ( 32296059) Meat-related diet ( 32066663) Neuroticism ( 29255261) Refractive error ( 32231278)
Novel Interacting Genes		1 novel interacting genes: CD244
Interacting Genes		7 interacting genes: APP ATXN1L C5AR2 CDC42 LINC00632 RNF10 SUMO4
Entrez ID		50
HPRD ID		00012
Ensembl ID		ENSG00000100412
Uniprot IDs		Q99798
PDB IDs
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Neuron Projection Organization Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Regulation Of Type II Interferon Production Cell Activation Involved In Immune Response Dendrite Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Regulation Of Interleukin-6 Production Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Postsynapse Organization Positive Regulation Of Type II Interferon Production Positive Regulation Of Small Molecule Metabolic Process Learning Lipoprotein Particle Memory Regulation Of Protein Localization To Nucleus Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Regulation Of Nervous System Process Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Apolipoprotein A-I Receptor Binding Endothelin Receptor Signaling Pathway Involved In Heart Process Apical Part Of Cell Neuropilin Signaling Pathway GBD Domain Binding Storage Vacuole Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Complement Component C5a Receptor Activity Regulation Of Interleukin-8 Production Complement Component C5a Signaling Pathway
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