MAPK6 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
CCT3	chaperonin containing TCP1 subunit 3	Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Phosphoaminophosphonic Acid-Adenylate Ester Artenimol
CDH13	cadherin 13	Adherens junctions interactions
CERS1	ceramide synthase 1	Sphingolipid de novo biosynthesis
CFAP298	cilia and flagella associated protein 298
CFL1	cofilin 1	Platelet degranulation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion RHO GTPases Activate ROCKs Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Dodecyldimethylamine N-oxide Copper Artenimol
CNTN1	contactin 1	Activated NOTCH1 Transmits Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus L1CAM interactions Neurofascin interactions
CNTRL	centriolin	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
COPS6	COP9 signalosome subunit 6	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
CSE1L	chromosome segregation 1 like
CYRIB	CYFIP related Rac1 interactor B	Platelet degranulation
CYTH2	cytohesin 2	Intra-Golgi traffic	Inositol 1,3,4,5-Tetrakisphosphate Formic acid 1D-myo-inositol 1,4,5-trisphosphate S,S-(2-Hydroxyethyl)Thiocysteine Brefeldin A
DBN1	drebrin 1
DCTN2	dynactin subunit 2	MHC class II antigen presentation Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic AURKA Activation by TPX2
DDOST	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	SRP-dependent cotranslational protein targeting to membrane Asparagine N-linked glycosylation Neutrophil degranulation Advanced glycosylation endproduct receptor signaling Maturation of spike protein
DDR1	discoidin domain receptor tyrosine kinase 1	Non-integrin membrane-ECM interactions	Imatinib Fostamatinib Pralsetinib
DGKZ	diacylglycerol kinase zeta	Effects of PIP2 hydrolysis	alpha-Tocopherol succinate
DKC1	dyskerin pseudouridine synthase 1	Telomere Extension By Telomerase rRNA modification in the nucleus and cytosol		Hoyeraal-Hreidarsson syndrome Dyskeratosis congenita (DC), including: X-linked dyskeratosis congenita (DKCX); Autosomal dominant dyskeratosis congenita (DKCA1); Autosomal recessive dyskeratosis congenita (DKCB1)
DNAJC28	DnaJ heat shock protein family (Hsp40) member C28
DPPA4	developmental pluripotency associated 4	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
DST	dystonin	Type I hemidesmosome assembly

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