DST - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
KIAA1549	KIAA1549	Signaling by BRAF and RAF fusions
KRT14	keratin 14	Type I hemidesmosome assembly Keratinization Formation of the cornified envelope	Zinc Zinc acetate	Naegeli-Franceschetti-Jadassohn syndrome Dermatopathia pigmentosa reticularis Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
KRT5	keratin 5	Type I hemidesmosome assembly Keratinization Formation of the cornified envelope	Zinc Zinc acetate	Dowling-Degos disease Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
LINC01554	long intergenic non-protein coding RNA 1554
MAPK6	mitogen-activated protein kinase 6	MAPK6/MAPK4 signaling	Acetylsalicylic acid Minocycline
MTNR1B	melatonin receptor 1B	Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events	Ramelteon Melatonin Resveratrol Agomelatine Tasimelteon	Type II diabetes mellitus
MYBPC2	myosin binding protein C2	Striated Muscle Contraction
NFYC	nuclear transcription factor Y subunit gamma	PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes
PAK2	p21 (RAC1) activated kinase 2	Nef and signal transduction Generation of second messenger molecules Regulation of PAK-2p34 activity by PS-GAP/RHG10 Regulation of activated PAK-2p34 by proteasome mediated degradation Stimulation of the cell death response by PAK-2p34 FCERI mediated MAPK activation FCERI mediated MAPK activation CD28 dependent Vav1 pathway Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 VEGFA-VEGFR2 Pathway Smooth Muscle Contraction VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Fostamatinib
PRKAB2	protein kinase AMP-activated non-catalytic subunit beta 2	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine metabolism Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs	Adenosine phosphate Acetylsalicylic acid Fostamatinib
PRKD2	protein kinase D2	Sphingolipid de novo biosynthesis
PTGER4	prostaglandin E receptor 4	Prostanoid ligand receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Dinoprostone Misoprostol Limaprost Castor oil Grapiprant
SH3BP5	SH3 domain binding protein 5
SMAD9	SMAD family member 9	Signaling by BMP
SNAPIN	SNAP associated protein	Golgi Associated Vesicle Biogenesis
TNIK	TRAF2 and NCK interacting kinase	Oxidative Stress Induced Senescence	Fostamatinib
TRAF3IP1	TRAF3 interacting protein 1	Intraflagellar transport Intraflagellar transport
TULP3	TUB like protein 3	Hedgehog 'off' state

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