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UBE2W |
ubiquitin conjugating enzyme E2 W |
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- Antigen processing: Ubiquitination & Proteasome degradation
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UBE3A |
ubiquitin protein ligase E3A |
- Antigen processing: Ubiquitination & Proteasome degradation
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- Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
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UBXN1 |
UBX domain protein 1 |
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
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USF2 |
upstream transcription factor 2, c-fos interacting |
- Estrogen-dependent gene expression
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USH2A |
usherin |
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- Usher syndrome (US)
- Retinitis pigmentosa (RP)
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USP2 |
ubiquitin specific peptidase 2 |
- TNFR1-induced proapoptotic signaling
- Regulation of TNFR1 signaling
- TNFR1-induced NFkappaB signaling pathway
- Ub-specific processing proteases
- Regulation of TP53 Degradation
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VCP |
valosin containing protein |
- Translesion Synthesis by POLH
- HSF1 activation
- ABC-family proteins mediated transport
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Hedgehog ligand biogenesis
- Hh mutants are degraded by ERAD
- Defective CFTR causes cystic fibrosis
- Josephin domain DUBs
- Ovarian tumor domain proteases
- Neutrophil degranulation
- E3 ubiquitin ligases ubiquitinate target proteins
- Protein methylation
- Aggrephagy
- Attachment and Entry
- Attachment and Entry
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- Phosphoaminophosphonic Acid-Adenylate Ester
- Phenethyl Isothiocyanate
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- Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
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WDR6 |
WD repeat domain 6 |
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WNT2B |
Wnt family member 2B |
- WNT ligand biogenesis and trafficking
- WNT ligand biogenesis and trafficking
- Class B/2 (Secretin family receptors)
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WRN |
WRN RecQ like helicase |
- Processive synthesis on the C-strand of the telomere
- Removal of the Flap Intermediate from the C-strand
- SUMOylation of DNA damage response and repair proteins
- HDR through Single Strand Annealing (SSA)
- HDR through Homologous Recombination (HRR)
- Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
- Resolution of D-loop Structures through Holliday Junction Intermediates
- Homologous DNA Pairing and Strand Exchange
- Processing of DNA double-strand break ends
- Presynaptic phase of homologous DNA pairing and strand exchange
- Regulation of TP53 Activity through Phosphorylation
- G2/M DNA damage checkpoint
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- Defects in RecQ helicases, including: Bloom's syndrome; Werner's syndrome; Rothmund-Thomson syndrome
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XIAP |
X-linked inhibitor of apoptosis |
- Activation of caspases through apoptosome-mediated cleavage
- SMAC (DIABLO) binds to IAPs
- SMAC (DIABLO) binds to IAPs
- SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
- SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
- SMAC, XIAP-regulated apoptotic response
- Deactivation of the beta-catenin transactivating complex
- RIPK1-mediated regulated necrosis
- Regulation of TNFR1 signaling
- TNFR1-induced NFkappaB signaling pathway
- Regulation of necroptotic cell death
- Regulation of PTEN localization
- Regulation of PTEN stability and activity
- Regulation of the apoptosome activity
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- 1-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-Amide
- Dequalinium
- N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE
- AEG35156
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- Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
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XRCC1 |
X-ray repair cross complementing 1 |
- Resolution of AP sites via the single-nucleotide replacement pathway
- APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
- HDR through MMEJ (alt-NHEJ)
- Gap-filling DNA repair synthesis and ligation in GG-NER
- Gap-filling DNA repair synthesis and ligation in TC-NER
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XRCC5 |
X-ray repair cross complementing 5 |
- 2-LTR circle formation
- Cytosolic sensors of pathogen-associated DNA
- IRF3-mediated induction of type I IFN
- Nonhomologous End-Joining (NHEJ)
- Neutrophil degranulation
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YY1 |
YY1 transcription factor |
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- UCH proteinases
- DNA Damage Recognition in GG-NER
- TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
- Estrogen-dependent gene expression
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ZNF280D |
zinc finger protein 280D |
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ZNF350 |
zinc finger protein 350 |
- Generic Transcription Pathway
- SUMOylation of transcription cofactors
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ZNF423 |
zinc finger protein 423 |
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- Systemic lupus erythematosus
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ZSCAN21 |
zinc finger and SCAN domain containing 21 |
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