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SUMO1 |
small ubiquitin like modifier 1 |
- SUMO is conjugated to E1 (UBA2:SAE1)
- SUMO is transferred from E1 to E2 (UBE2I, UBC9)
- SUMO is proteolytically processed
- SUMOylation of DNA damage response and repair proteins
- SUMO E3 ligases SUMOylate target proteins
- SUMOylation of transcription factors
- SUMOylation of transcription factors
- SUMOylation of ubiquitinylation proteins
- SUMOylation of transcription cofactors
- SUMOylation of transcription cofactors
- SUMOylation of SUMOylation proteins
- SUMOylation of intracellular receptors
- SUMOylation of intracellular receptors
- SUMOylation of chromatin organization proteins
- SUMOylation of chromatin organization proteins
- SUMOylation of RNA binding proteins
- SUMOylation of DNA replication proteins
- SUMOylation of DNA replication proteins
- SUMOylation of DNA methylation proteins
- SUMOylation of DNA methylation proteins
- SUMOylation of immune response proteins
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Nonhomologous End-Joining (NHEJ)
- Processing of DNA double-strand break ends
- Formation of Incision Complex in GG-NER
- G2/M DNA damage checkpoint
- Regulation of IFNG signaling
- Negative regulation of activity of TFAP2 (AP-2) family transcription factors
- Negative regulation of activity of TFAP2 (AP-2) family transcription factors
- Postmitotic nuclear pore complex (NPC) reformation
- Maturation of nucleoprotein
- Maturation of nucleoprotein
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SYT6 |
synaptotagmin 6 |
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TARS1 |
threonyl-tRNA synthetase 1 |
- Cytosolic tRNA aminoacylation
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TATDN2 |
TatD DNase domain containing 2 |
- XBP1(S) activates chaperone genes
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TCEA2 |
transcription elongation factor A2 |
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TCEANC |
transcription elongation factor A N-terminal and central domain containing |
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TEX101 |
testis expressed 101 |
- Post-translational modification: synthesis of GPI-anchored proteins
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THOC3 |
THO complex 3 |
- Transport of Mature mRNA derived from an Intron-Containing Transcript
- mRNA 3'-end processing
- RNA Polymerase II Transcription Termination
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TLE4 |
TLE family member 4, transcriptional corepressor |
- Formation of the beta-catenin:TCF transactivating complex
- NOTCH1 Intracellular Domain Regulates Transcription
- Deactivation of the beta-catenin transactivating complex
- Repression of WNT target genes
- Repression of WNT target genes
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TMPRSS12 |
transmembrane serine protease 12 |
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TNS2 |
tensin 2 |
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TOP1 |
DNA topoisomerase I |
- SUMOylation of DNA replication proteins
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- Irinotecan
- Topotecan
- Camptothecin
- Edotecarin
- Lucanthone
- Elsamitrucin
- 7-ethyl-10-hydroxycamptothecin
- Sodium stibogluconate
- Cositecan
- XMT-1001
- Rubitecan
- 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM
- 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE
- Hexylresorcinol
- Sacituzumab govitecan
- Trastuzumab deruxtecan
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TOP2A |
DNA topoisomerase II alpha |
- Transcription of E2F targets under negative control by DREAM complex
- SUMOylation of DNA replication proteins
- SUMOylation of DNA replication proteins
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- Moxifloxacin
- Amsacrine
- Dexrazoxane
- Valrubicin
- Teniposide
- Epirubicin
- Enoxacin
- Pefloxacin
- Ciprofloxacin
- Trovafloxacin
- Daunorubicin
- Etoposide
- Dactinomycin
- Lomefloxacin
- Doxorubicin
- Norfloxacin
- Ofloxacin
- Idarubicin
- Podofilox
- Mitoxantrone
- Sparfloxacin
- Genistein
- Fleroxacin
- Lucanthone
- Banoxantrone
- SP1049C
- Amonafide
- Elsamitrucin
- 13-deoxydoxorubicin
- RTA 744
- Aldoxorubicin
- ZEN-012
- Amrubicin
- Becatecarin
- Annamycin
- Declopramide
- Finafloxacin
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TP53 |
tumor protein p53 |
- Activation of NOXA and translocation to mitochondria
- Activation of PUMA and translocation to mitochondria
- Pre-NOTCH Transcription and Translation
- Oxidative Stress Induced Senescence
- Formation of Senescence-Associated Heterochromatin Foci (SAHF)
- Oncogene Induced Senescence
- DNA Damage/Telomere Stress Induced Senescence
- SUMOylation of transcription factors
- Autodegradation of the E3 ubiquitin ligase COP1
- Association of TriC/CCT with target proteins during biosynthesis
- TP53 Regulates Metabolic Genes
- Ub-specific processing proteases
- Ovarian tumor domain proteases
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Interleukin-4 and Interleukin-13 signaling
- TP53 Regulates Transcription of DNA Repair Genes
- TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
- TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
- TP53 Regulates Transcription of Caspase Activators and Caspases
- TP53 Regulates Transcription of Death Receptors and Ligands
- TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
- TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
- TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
- Regulation of TP53 Expression
- Regulation of TP53 Activity through Phosphorylation
- Regulation of TP53 Degradation
- Regulation of TP53 Activity through Acetylation
- Regulation of TP53 Activity through Association with Co-factors
- Regulation of TP53 Activity through Methylation
- PI5P Regulates TP53 Acetylation
- G2/M DNA damage checkpoint
- G2/M Checkpoints
- Stabilization of p53
- Transcriptional activation of cell cycle inhibitor p21
- The role of GTSE1 in G2/M progression after G2 checkpoint
- Transcriptional Regulation by VENTX
- RUNX3 regulates CDKN1A transcription
- Regulation of PTEN gene transcription
- Regulation of PTEN gene transcription
- Factors involved in megakaryocyte development and platelet production
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- Acetylsalicylic acid
- Zinc
- Triethyl phosphate
- AZD 3355
- 1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine
- Zinc acetate
- Zinc chloride
- Zinc sulfate, unspecified form
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- Osteosarcoma
- Adrenal carcinoma
- Thyroid cancer
- Breast cancer
- Basal cell carcinoma
- Malignant melanoma
- Pancreatic cancer
- Gastric cancer
- Malignant pleural mesothelioma
- Non-small cell lung cancer
- Esophageal cancer
- Oral cancer
- Multiple myeloma
- Small cell lung cancer
- Li-Fraumeni syndrome, including: Classic Li-Fraumeni syndrome (LFS); LFS-like syndrome (LFSL)
- Glioma
- Squamous cell carcinoma
- Kaposi's sarcoma
- Cholangiocarcinoma
- Gallbladder cancer
- Cancer of the anal canal
- Hepatocellular carcinoma
- Choriocarcinoma
- Vulvar cancer
- Choroid plexus papilloma
- Burkitt lymphoma
- Adult T-cell leukemia
- Hairy-cell leukemia
- Bladder cancer
- Chronic lymphocytic leukemia (CLL)
- Penile cancer
- Endometrial Cancer
- Ovarian cancer
- Colorectal cancer
- Laryngeal cancer
- Chronic myeloid leukemia (CML)
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TP53BP1 |
tumor protein p53 binding protein 1 |
- SUMOylation of transcription factors
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Nonhomologous End-Joining (NHEJ)
- Processing of DNA double-strand break ends
- G2/M DNA damage checkpoint
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TPTE2 |
transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 |
- Synthesis of PIPs at the Golgi membrane
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TRIM24 |
tripartite motif containing 24 |
- Signaling by cytosolic FGFR1 fusion mutants
- Signaling by FGFR1 in disease
- Signaling by BRAF and RAF fusions
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TRIM46 |
tripartite motif containing 46 |
- Interferon gamma signaling
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TRIM74 |
tripartite motif containing 74 |
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TRRAP |
transformation/transcription domain associated protein |
- Formation of the beta-catenin:TCF transactivating complex
- Formation of the beta-catenin:TCF transactivating complex
- HATs acetylate histones
- Ub-specific processing proteases
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