PUM3 and GPER1

		PUM3	GPER1
Description		pumilio RNA binding family member 3	G protein-coupled estrogen receptor 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Endoplasmic Reticulum	Golgi Membrane Nucleus Nuclear Envelope Nucleoplasm Nucleolus Cytoplasm Mitochondrion Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Postsynaptic Density Membrane Axon Dendrite Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Mitochondrial Membrane Dendritic Spine Membrane Presynaptic Membrane Cell Projection Dendritic Shaft Axon Terminus Dendritic Spine Head Keratin Filament Synapse Perinuclear Region Of Cytoplasm Presynaptic Active Zone Recycling Endosome Hippocampal Mossy Fiber To CA3 Synapse
	Molecular Function	DNA Binding RNA Binding MRNA Binding Protein Binding	Chromatin Binding G Protein-coupled Receptor Activity Steroid Binding Protein Binding Nuclear Estrogen Receptor Activity G Protein-coupled Estrogen Receptor Activity Steroid Hormone Binding
	Biological Process	Regulation Of Translation Regulation Of Protein ADP-ribosylation	Positive Regulation Of Protein Phosphorylation Positive Regulation Of Neurotransmitter Secretion Immune System Process Negative Regulation Of Leukocyte Activation Apoptotic Process Inflammatory Response Cell Communication Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Nervous System Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Cell Cycle Process Neuronal Action Potential Cell Differentiation Apoptotic Chromosome Condensation Nuclear Fragmentation Involved In Apoptotic Nuclear Change Positive Regulation Of Cell Migration Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Positive Regulation Of Insulin Secretion Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Vasodilation Positive Regulation Of Apoptotic Process Steroid Hormone Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Innate Immune Response Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of Neurogenesis Modulation Of Chemical Synaptic Transmission Positive Regulation Of Transport Negative Regulation Of Lipid Biosynthetic Process Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Cell Cycle Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Uterine Smooth Muscle Contraction Cellular Response To Glucose Stimulus Cellular Response To Tumor Necrosis Factor Cellular Response To Peptide Hormone Stimulus Cellular Response To Mineralocorticoid Stimulus Cellular Response To Estradiol Stimulus Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Peptide ligand-binding receptors G alpha (i) signalling events GPER1 signaling
Drugs			Estradiol Genistein MK-0354 Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate
Diseases
GWAS		Depression ( 29700475) Smoking initiation ( 33082346) Waist circumference adjusted for body mass index ( 28552196)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Prostate cancer ( 31748686) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		12 interacting genes: AK3 APP ARFIP2 CALM1 CEBPA GPER1 HPS6 ITGB1BP2 PCDHB15 RCL1 RPS29 SLC7A9	1 interacting genes: PUM3
Entrez ID		9933	2852
HPRD ID		08822	03484
Ensembl ID		ENSG00000080608	ENSG00000164850
Uniprot IDs		Q15397	Q63ZY2 Q99527
PDB IDs		4WZR 4WZW	8XOF 8XOG 8XOH 8XOI 8XOJ
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Dendritic Shaft Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Response To Metal Ion Chemical Homeostasis Intermediate-density Lipoprotein Particle Regulation Of Monoatomic Ion Transport Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Intracellular Signaling Cassette Regulation Of Membrane Potential Trans-Golgi Network Membrane Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Early Endosome Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Response To Peptide Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Synaptic Transmission Response To Cytokine Regulation Of Inflammatory Response Regulation Of Calcium-mediated Signaling Regulation Of Calcium Ion Transport Regulation Of Metal Ion Transport Protein Heterodimerization Activity Lipoprotein Particle Memory Growth Factor Receptor Binding Main Axon Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Regulation Of Monoatomic Cation Transmembrane Transport	Regulation Of Protein ADP-ribosylation
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