TELO2 and IFT140

		TELO2	IFT140
Description		telomere maintenance 2	intraflagellar transport 140
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Chromosome Cytoplasm Cytosol Membrane Nuclear Body TTT Hsp90 Cochaperone Complex	Nucleoplasm Cytoplasm Mitochondrion Centrosome Centriole Cytoskeleton Cilium Axoneme Intraciliary Transport Particle A Photoreceptor Connecting Cilium Ciliary Basal Body Cell Projection Ciliary Tip Non-motile Cilium Cone Photoreceptor Outer Segment
	Molecular Function	Protein Binding Protein Kinase Binding Telomeric DNA Binding Protein-containing Complex Binding Hsp90 Protein Binding Molecular Adaptor Activity	Protein Binding
	Biological Process	Protein Stabilization 'de Novo' Cotranslational Protein Folding Positive Regulation Of DNA Damage Checkpoint	Determination Of Left/right Symmetry Heart Development Regulation Of Smoothened Signaling Pathway Neural Tube Patterning Cell Projection Organization Embryonic Camera-type Eye Development Limb Morphogenesis Intraciliary Retrograde Transport Photoreceptor Cell Outer Segment Organization Intraciliary Transport Embryonic Digit Morphogenesis Embryonic Cranial Skeleton Morphogenesis Cilium Assembly Protein Localization To Cilium Regulation Of Cilium Assembly Non-motile Cilium Assembly Embryonic Brain Development
Pathways			Hedgehog 'off' state Intraflagellar transport
Drugs
Diseases
GWAS		Rheumatoid arthritis ( 30891314)	Coronary artery disease ( 29212778 33020668) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383)
Interacting Genes		5 interacting genes: CACNA1A IFT140 KAT5 KRT15 MTOR	12 interacting genes: CELSR3 CRK DNAJA3 IL32 NEK2 NHERF2 PFDN1 RAB11FIP3 RANBP2 TELO2 TRAP1 ZNF263
Entrez ID		9894	9742
HPRD ID		10016	11093
Ensembl ID		ENSG00000100726	ENSG00000187535
Uniprot IDs		B4DXS2 Q9Y4R8	Q96RY7
PDB IDs		4PSI 7F4U 7OLE	8BBF 8BBG 8FGW 8FH3
Enriched GO Terms of Interacting Partners?		Cellular Response To Oxygen-containing Compound Positive Regulation Of Pentose-phosphate Shunt Positive Regulation Of Cytoplasmic Translational Initiation Response To Methionine Germ Cell Development Regulation Of Circadian Rhythm TORC1 Complex Inositol Hexakisphosphate Binding Organelle Organization RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding Regulation Of Locomotor Rhythm Regulation Of NADP Metabolic Process Positive Regulation Of Autophagy Macroautophagy TFIIIC-class Transcription Factor Complex Binding Regulation Of Pentose-phosphate Shunt Pyrimidine Nucleobase Biosynthetic Process RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding Regulation Of Organelle Assembly Regulation Of Cell Projection Assembly Negative Regulation Of TORC2 Signaling Cellular Response To Methionine Voluntary Musculoskeletal Movement Cellular Response To Nutrient Levels 'de Novo' Pyrimidine Nucleobase Biosynthetic Process Regulation Of Macroautophagy Organelle Assembly Negative Regulation Of Lysosome Organization Cellular Response To Starvation Tissue Development Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of T Cell Activation T-helper 1 Cell Lineage Commitment Cytoskeleton Organization RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding Response To Starvation Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Regulation Of Lipid Biosynthetic Process Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Intraciliary Transport Particle A Neural Tube Patterning Cone Photoreceptor Outer Segment Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Histone H2AK5 Acetyltransferase Activity Piccolo Histone Acetyltransferase Complex Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Histone H4K16 Acetyltransferase Activity Peptide Crotonyltransferase Activity	Protein Folding Negative Regulation Of Innate Immune Response Protein Localization To Membrane Unfolded Protein Binding Protein-containing Complex Binding Molecular Adaptor Activity Negative Regulation Of Immune Response Localization Within Membrane Helper T Cell Diapedesis Cerebellar Neuron Development Protein Phosphorylated Amino Acid Binding Negative Regulation Of Defense Response Neuromuscular Junction Response To Cholecystokinin Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Negative Regulation Of Centriole-centriole Cohesion Regulation Of Centriole-centriole Cohesion Intercellular Bridge Cytoplasmic Periphery Of The Nuclear Pore Complex IkappaB Kinase Complex Binding Type II Interferon Receptor Binding Positive Regulation Of Type III Interferon Production Type 3 Metabotropic Glutamate Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Protein Localization To Cleavage Furrow 'de Novo' Cotranslational Protein Folding TTT Hsp90 Cochaperone Complex Translational Attenuation
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