IPO13 and PPFIA2

		IPO13	PPFIA2
Description		importin 13	PPFI scaffold protein A2
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GO Annotations	Cellular Component	Nucleus Cytoplasm	Cytoplasm Cytosol Synaptic Vesicle Cell Surface Postsynaptic Density Axon Presynaptic Membrane Cell Projection Dendritic Spine Synapse Presynaptic Active Zone Extracellular Exosome Glutamatergic Synapse Postsynaptic Specialization
	Molecular Function	Protein Binding Small GTPase Binding	Protein Binding Structural Constituent Of Postsynaptic Density Structural Constituent Of Presynapse
	Biological Process	Protein Import Into Nucleus Intracellular Protein Transport Protein Transport	Cell-matrix Adhesion Synapse Organization Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Presynapse Organization Dense Core Granule Cytoskeletal Transport Maintenance Of Postsynaptic Density Structure Regulation Of Synaptic Vesicle Exocytosis
Pathways			Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026)	Age-related cataracts (age at onset) ( 25352737) Alcohol dependence ( 26365420) Delirium ( 29631748) Femur bone mineral density x serum urate levels interaction ( 34046847) Lean body mass ( 28552196) Post bronchodilator FEV1 ( 26634245) Resting heart rate ( 27798624) Schizophrenia ( 22885689)
Interacting Genes		30 interacting genes: ALX1 ARX CDK1 CRX EIF1AX EIF2B3 EIF3I EIF4B GK HMBOX1 KDM4A MAGOH MAST2 NOSIP NPSR1 NUP50 PAX3 PAX6 PBX4 PIK3R3 PITX1 PPFIA2 PPIH PREX1 PSMA1 RAN RBM8A RNF10 RPL5 UBE2I	16 interacting genes: CAST CDC5L ERC2 GIT1 IPO13 ITSN1 MTDH PPFIA1 PPFIA3 PPFIBP1 PPFIBP2 PTPRD PTPRF PTPRS SMARCA2 TSC1
Entrez ID		9670	8499
HPRD ID		13742	04392
Ensembl ID		ENSG00000117408	ENSG00000139220
Uniprot IDs		O94829	B7Z7Y5 G3V200 H0YHK3 O75334
PDB IDs		2X19 2XWU 3ZJY	3TAC 3TAD 6IUH 7D2E 7D2G 7D2H
Enriched GO Terms of Interacting Partners?		Translation Initiation Factor Activity Chromatin Translational Initiation Exon-exon Junction Subcomplex Mago-y14 Cytosol Sequence-specific Double-stranded DNA Binding Nuclear Export Nuclear Transport Nucleocytoplasmic Transport RNA Transport RNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Neuron Development Translation Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex RNA Export From Nucleus Nuclear Pore Nucleobase-containing Compound Transport Translation Factor Activity, RNA Binding Exon-exon Junction Complex Cell Development Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Nucleoplasm Pronuclear Fusion Regulation Of Macromolecule Metabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Chromatin Binding Cytoplasm Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Glycerol Kinase Activity Glycerol-3-phosphate Biosynthetic Process MRNA Transport Sequence-specific DNA Binding Forebrain-midbrain Boundary Formation Pituitary Gland Development Pancreatic A Cell Development SUMO Conjugating Enzyme Activity Structural Constituent Of Presynapse Cytoplasmic Translational Initiation	Synapse Organization Presynaptic Active Zone Cell Junction Organization Synaptic Membrane Adhesion Presynaptic Membrane Glutamatergic Synapse Regulation Of Dendritic Spine Development Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Cortical Microtubule Organization Presynaptic Active Zone Organization Regulation Of Organelle Organization Presynaptic Active Zone Cytoplasmic Component Schaffer Collateral - CA1 Synapse Protein Tyrosine Phosphatase Activity Regulation Of Postsynaptic Density Assembly Cell Adhesion Transmembrane Receptor Protein Tyrosine Phosphatase Activity Regulation Of Cellular Component Organization Regulation Of Postsynaptic Specialization Assembly Regulation Of Excitatory Synapse Assembly Peptidyl-tyrosine Dephosphorylation Neuron Projection Regulation Of Postsynapse Organization Phosphoprotein Phosphatase Activity Regulation Of Axon Regeneration Growth Cone Regulation Of Neuron Projection Regeneration Maintenance Of Synapse Structure Regulation Of Response To Wounding Neuromuscular Junction Development Cell Cortex Positive Regulation Of Dendritic Spine Development Lamellipodium Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Modulation Of Chemical Synaptic Transmission Chondroitin Sulfate Proteoglycan Binding Memory T Cell Differentiation Cortical Cytoskeleton Organization Epididymosome Negative Regulation Of ARF Protein Signal Transduction Cell Junction Maintenance Synapse Presynapse Nervous System Development Postsynaptic Density Cytoplasmic Microtubule Organization Regulation Of Cell Junction Assembly Clathrin-dependent Synaptic Vesicle Endocytosis Cellular Component Maintenance
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