CD48 and LY9

		CD48	LY9
Description		CD48 molecule	lymphocyte antigen 9
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Membrane Raft Extracellular Exosome Side Of Membrane	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Protein Binding Receptor Ligand Activity
	Biological Process	Defense Response Immune Response Signal Transduction Natural Killer Cell Activation Leukocyte Activation	Adaptive Immune Response Immune System Process Immune Response Cell Adhesion Positive Regulation Of Interleukin-17 Production T Cell Activation Innate Immune Response T-helper 17 Cell Lineage Commitment
Pathways		Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Multiple sclerosis ( 31604244) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) White blood cell count ( 32888494)
Interacting Genes		20 interacting genes: ACKR1 BRIX1 CD2 CD244 CD247 DIO1 E2F2 EEF1D EFNA1 EFNA3 FYN GNAI3 IL18R1 IL18RAP KPLCE LCK LY9 MAST2 OAZ3 P4HA1	5 interacting genes: AP2M1 CD48 KPLCE SH2D1A SH2D1B
Entrez ID		962	4063
HPRD ID		00177	02817
Ensembl ID		ENSG00000117091	ENSG00000122224
Uniprot IDs		A0A087X1S7 P09326	A0A0C4DFU4 Q05CA2 Q0VAI0 Q5VYH9 Q9HBG7
PDB IDs		2EDO
Enriched GO Terms of Interacting Partners?		Leukocyte Activation Natural Killer Cell Activation Cell Activation Lymphocyte Activation T Cell Activation Adaptive Immune Response Interleukin-18 Receptor Complex Interleukin-18 Receptor Activity Ephrin Receptor Binding Fc-gamma Receptor Signaling Pathway CD8 Receptor Binding Signaling Receptor Activity Ephrin Receptor Signaling Pathway Fc Receptor Signaling Pathway CD4 Receptor Binding Plasma Membrane Phospholipase Activator Activity Positive Regulation Of Type II Interferon Production T Cell Receptor Binding Positive Regulation Of Immune System Process Interleukin-18-mediated Signaling Pathway NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Signal Transduction Phosphatidylinositol 3-kinase Binding Cell Surface Receptor Signaling Pathway Immune Response T Cell Receptor Signaling Pathway Gamma-delta T Cell Activation Phospholipase Binding Regulation Of Type II Interferon Production Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Vasculature Development Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Positive Regulation Of Metabolic Process Antigen Receptor-mediated Signaling Pathway Immune System Process Regulation Of Multicellular Organismal Process Positive Regulation Of Immune Response Immune Effector Process Signaling Receptor Binding Cellular Response To Glycine Response To Singlet Oxygen Non-membrane Spanning Protein Tyrosine Kinase Activity Cellular Response To Interleukin-18 Positive Regulation Of Macromolecule Metabolic Process T Cell Costimulation Regulation Of Metabolic Process Regulation Of Immune System Process	Natural Killer Cell Activation Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Immunity Leukocyte Activation Cell Activation Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Synaptic Vesicle Recycling Postsynaptic Neurotransmitter Receptor Internalization Signal Sequence Binding Extrinsic Component Of Presynaptic Endocytic Zone Membrane Positive Regulation Of Immune Effector Process Protein-macromolecule Adaptor Activity Regulation Of Lymphocyte Mediated Immunity Immune Response Adaptive Immune Response Positive Regulation Of Innate Immune Response AP-2 Adaptor Complex Clathrin Adaptor Complex Defense Response Clathrin Adaptor Activity Endolysosome Membrane Regulation Of Vesicle Size Immune Effector Process Lymphocyte Activation Clathrin-coated Endocytic Vesicle Regulation Of Synaptic Vesicle Endocytosis Regulation Of Innate Immune Response Positive Regulation Of Defense Response Positive Regulation Of Receptor Internalization Low-density Lipoprotein Particle Receptor Binding Negative Regulation Of Protein Localization To Plasma Membrane Clathrin-dependent Endocytosis Disordered Domain Specific Binding Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of T Cell Receptor Signaling Pathway Vesicle Budding From Membrane Immune System Process Synaptic Vesicle Endocytosis Natural Killer Cell Mediated Cytotoxicity Presynaptic Endocytosis Natural Killer Cell Mediated Immunity Innate Immune Response Positive Regulation Of Immune Response Cellular Defense Response Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Natural Killer Cell Mediated Cytotoxicity
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