CD48 and KPLCE

		CD48	KPLCE
Description		CD48 molecule	KPRP N-terminal and LCE C-terminal like protein
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Membrane Raft Extracellular Exosome Side Of Membrane
	Molecular Function	Protein Binding Receptor Ligand Activity
	Biological Process	Defense Response Immune Response Signal Transduction Natural Killer Cell Activation Leukocyte Activation	Epidermis Development
Pathways		Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Multiple sclerosis ( 31604244) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		20 interacting genes: ACKR1 BRIX1 CD2 CD244 CD247 DIO1 E2F2 EEF1D EFNA1 EFNA3 FYN GNAI3 IL18R1 IL18RAP KPLCE LCK LY9 MAST2 OAZ3 P4HA1	2 interacting genes: CD48 LY9
Entrez ID		962	100129271
HPRD ID		00177	19444
Ensembl ID		ENSG00000117091	ENSG00000198854
Uniprot IDs		A0A087X1S7 P09326	Q5T750
PDB IDs		2EDO
Enriched GO Terms of Interacting Partners?		Leukocyte Activation Natural Killer Cell Activation Cell Activation Lymphocyte Activation T Cell Activation Adaptive Immune Response Interleukin-18 Receptor Complex Interleukin-18 Receptor Activity Ephrin Receptor Binding Fc-gamma Receptor Signaling Pathway CD8 Receptor Binding Signaling Receptor Activity Ephrin Receptor Signaling Pathway Fc Receptor Signaling Pathway CD4 Receptor Binding Plasma Membrane Phospholipase Activator Activity Positive Regulation Of Type II Interferon Production T Cell Receptor Binding Positive Regulation Of Immune System Process Interleukin-18-mediated Signaling Pathway NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Signal Transduction Phosphatidylinositol 3-kinase Binding Cell Surface Receptor Signaling Pathway Immune Response T Cell Receptor Signaling Pathway Gamma-delta T Cell Activation Phospholipase Binding Regulation Of Type II Interferon Production Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Vasculature Development Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Positive Regulation Of Metabolic Process Antigen Receptor-mediated Signaling Pathway Immune System Process Regulation Of Multicellular Organismal Process Positive Regulation Of Immune Response Immune Effector Process Signaling Receptor Binding Cellular Response To Glycine Response To Singlet Oxygen Non-membrane Spanning Protein Tyrosine Kinase Activity Cellular Response To Interleukin-18 Positive Regulation Of Macromolecule Metabolic Process T Cell Costimulation Regulation Of Metabolic Process Regulation Of Immune System Process	Leukocyte Activation Cell Activation Lymphocyte Activation T-helper Cell Lineage Commitment CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment T-helper 17 Cell Lineage Commitment Alpha-beta T Cell Lineage Commitment CD4-positive, Alpha-beta T Cell Lineage Commitment Positive Regulation Of Interleukin-17 Production T Cell Lineage Commitment Immune Response Defense Response Natural Killer Cell Activation
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