CIRSR and SLC25A17

		CIRSR	SLC25A17
Description		corepressor of RBPJ and splicing regulator	solute carrier family 25 member 17
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytoskeleton Nuclear Speck Protein-containing Complex	Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Membrane
	Molecular Function	Transcription Corepressor Activity Protein Binding Protein Kinase Binding Histone Deacetylase Binding Protein-containing Complex Binding	Adenine Nucleotide Transmembrane Transporter Activity ATP Transmembrane Transporter Activity Protein Binding ADP Transmembrane Transporter Activity Coenzyme A Transmembrane Transporter Activity FAD Transmembrane Transporter Activity Antiporter Activity FMN Transmembrane Transporter Activity Protein-folding Chaperone Binding NAD Transmembrane Transporter Activity AMP Transmembrane Transporter Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development MRNA Processing RNA Splicing Negative Regulation Of DNA-templated Transcription	Fatty Acid Alpha-oxidation Fatty Acid Beta-oxidation ADP Transport ATP Transport Fatty Acid Transport Coenzyme A Transmembrane Transport FAD Transmembrane Transport NAD Transmembrane Transport Transmembrane Transport AMP Transport Nucleotide Transmembrane Transport
Pathways			Alpha-oxidation of phytanate Class I peroxisomal membrane protein import
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756 34002096) Bipolar I disorder ( 31043756) Coffee consumption ( 31046077) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Feeling nervous ( 29500382) Irritable mood ( 29500382) Low density lipoprotein cholesterol levels ( 29083408) Neurociticism ( 29500382) Refractive error ( 32231278)
Interacting Genes		18 interacting genes: CCDC33 CEP76 DPPA4 FXR1 HDAC2 HOXA1 MB21D2 NCOR2 NEK6 OGT RBPJ RP9 SAP30 SLC25A17 SNW1 SRSF2 TCEA1 U2AF1	10 interacting genes: CACNA1S CD55 CIRSR DESI1 GRAP2 KCNJ13 MEOX2 PEX19 SEPTIN3 ZC3H7B
Entrez ID		9541	10478
HPRD ID		05568	08425
Ensembl ID		ENSG00000138433	ENSG00000100372
Uniprot IDs		Q86X95	B4DP73 B4DU97 F6RTR7 O43808
PDB IDs		6ZYM 8I0W
Enriched GO Terms of Interacting Partners?		Sin3-type Complex Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of RNA Metabolic Process Regulation Of Stem Cell Population Maintenance Transcription Corepressor Activity Regulation Of Behavior Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Retinoic Acid Receptor Binding Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Notch Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Male Mating Behavior Nucleoplasm Regulation Of RNA Metabolic Process Nucleus Histone Deacetylase Complex Protein-containing Complex Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway DNA-binding Transcription Factor Binding Semicircular Canal Formation Positive Regulation Of Ephrin Receptor Signaling Pathway Arterial Endothelial Cell Fate Commitment RNA Splicing Nuclear Speck Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Nuclear Receptor Binding FMN Transmembrane Transporter Activity FAD Transmembrane Transporter Activity FAD Transmembrane Transport Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin Binding Positive Regulation Of Neurogenesis Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Protein De-2-hydroxyisobutyrylase Activity Positive Regulation Of Developmental Process Regulation Of Transcription By RNA Polymerase II Artery Morphogenesis Abducens Nerve Formation Optokinetic Behavior Transcription Repressor Complex
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