CD83 and PAPSS2

		CD83	PAPSS2
Description		CD83 molecule	3'-phosphoadenosine 5'-phosphosulfate synthase 2
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Nucleus Cytosol
	Molecular Function	Protein Binding	Nucleotide Binding Catalytic Activity Adenylylsulfate Kinase Activity Sulfate Adenylyltransferase (ATP) Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Nucleotidyltransferase Activity
	Biological Process	Immune System Process Defense Response Humoral Immune Response Signal Transduction Negative Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-2 Production CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation	Sulfate Assimilation Hormone Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process
Pathways			Transport and metabolism of PAPS Metabolism of ingested H2SeO4 and H2SeO3 into H2Se Defective PAPSS2 causes SEMD-PA
Drugs
Diseases			SEMD, Pakistani type
GWAS		Breast cancer and/or colorectal cancer ( 29698419) California verbal learning test score ( 31596458) Chronotype ( 30696823) Obesity-related traits ( 23251661) Response to tofacitinib treatment (herpes zoster) ( 33455090) Response to tofacitinib treatment (herpes zoster)(time to event) ( 33455090) Response to tofacitinib treatment in psoriasis (herpes zoster) ( 33455090) Response to tofacitinib treatment in psoriasis (herpes zoster)(time to event) ( 33455090) Rheumatoid arthritis ( 22446963 24390342 30423114)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549) Leisure-time exercise behaviour ( 19727025) Magnesium levels ( 26685716) Serum metabolite levels ( 33031748)
Interacting Genes		10 interacting genes: EIF4E FAM8A1 FATE1 GCM2 GMPR KIF13A NOL7 PAPSS2 SACS SPP1	6 interacting genes: APP CD83 CEP19 DAPK1 HSF2BP TLL2
Entrez ID		9308	9060
HPRD ID		05170	04303
Ensembl ID		ENSG00000112149	ENSG00000198682
Uniprot IDs		A0A087WX61 Q01151	O95340 Q5TB52
PDB IDs		5MIX 5MJ0 5MJ1 5MJ2	2AX4 7FH3 7FHA 8I1N 8I1O
Enriched GO Terms of Interacting Partners?		Eukaryotic Initiation Factor 4G Binding GMP Reductase Activity GMP Reductase Complex Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Positive Regulation Of Estradiol Secretion 3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process Sulfate Assimilation Sulfate Adenylyltransferase (ATP) Activity Adenylylsulfate Kinase Activity Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Estradiol Secretion	Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Vesicle Targeting, Trans-Golgi To Periciliary Membrane Compartment Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Regulation Of NMDA Receptor Activity Negative Regulation Of Skeletal Muscle Tissue Growth Vesicle Targeting, To, From Or Within Golgi Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Regulation Of Skeletal Muscle Tissue Growth Negative Regulation Of Interleukin-4 Production Female Meiosis I Peptidase Activator Activity Cellular Response To Manganese Ion Extracellular Matrix Organization Extracellular Structure Organization Heparan Sulfate Binding Signaling Receptor Activator Activity Cellular Response To Hydroperoxide Humoral Immune Response Defense Response To Tumor Cell
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