ATG12 and SRP19

		ATG12	SRP19
Description		autophagy related 12	signal recognition particle 19
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GO Annotations	Cellular Component	Autophagosome Membrane Nucleoplasm Cytoplasm Autophagosome Cytosol Membrane Phagocytic Vesicle Membrane Protein-containing Complex Phagophore Assembly Site Membrane Atg12-Atg5-Atg16 Complex Transferase Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Signal Recognition Particle, Endoplasmic Reticulum Targeting Cytosol Nuclear Body Signal Recognition Particle Ribonucleoprotein Complex
	Molecular Function	Protein Binding Atg8-family Ligase Activity Protein Tag Activity	RNA Binding Protein Binding 7S RNA Binding Ribosome Binding
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Autophagy Macroautophagy Negative Regulation Of Type I Interferon Production Piecemeal Microautophagy Of The Nucleus Negative Regulation Of Innate Immune Response Negative Regulation Of Defense Response To Virus Glycophagy Autophagosome Maturation Regulation Of Autophagosome Maturation Positive Regulation Of Viral Translation	Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane, Signal Sequence Recognition
Pathways		Macroautophagy Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy Negative regulators of DDX58/IFIH1 signaling	SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane
Drugs
Diseases
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		19 interacting genes: APP ATG10 ATG3 ATG5 ATG7 CRX DOCK9 IER2 KRTAP4-12 MDFI MEOX2 NLRP6 PLSCR1 PRKACA PTK2 RB1CC1 SERTAD1 SERTAD2 SRP19	11 interacting genes: AP3S1 APP ATG12 CEBPA IPO5 IPO7 IPO8 KPNA1 MAPK8IP2 SRP54 TNPO1
Entrez ID		9140	6728
HPRD ID		08496	01644
Ensembl ID		ENSG00000145782	ENSG00000153037
Uniprot IDs		O94817	A0A087WYR0 A0A2U3TZN1 P09132
PDB IDs		4GDK 4GDL 4NAW	1JID 1MFQ 1RY1 2J37 3KTV 4P3E 5M73 7NFX 7QWQ
Enriched GO Terms of Interacting Partners?		Autophagy Of Mitochondrion Nucleophagy Autophagosome Assembly Autophagosome Organization Macroautophagy Vacuole Organization Piecemeal Microautophagy Of The Nucleus Atg12 Transferase Activity Negative Regulation Of Phagocytosis Microautophagy Atg8-family Ligase Activity Regulation Of Phagocytosis Phagophore Assembly Site Positive Regulation Of Metabolic Process Defense Response To Virus Autophagy Regulation Of Endocytosis Atg12-Atg5-Atg16 Complex Mitophagy Regulation Of Mucus Secretion Response To Virus Negative Regulation Of Endocytosis Cellular Response To Nitrogen Starvation Cellular Component Assembly Glycophagy Vascular Endothelial Cell Response To Fluid Shear Stress Cytoplasm Cytosol Response To Lead Ion Ubiquitin-like Protein Transferase Activity Glycogen Catabolic Process Regulation Of Vesicle-mediated Transport Phagophore Assembly Site Membrane Positive Regulation Of Catabolic Process Axoneme Polysaccharide Catabolic Process Molecular Function Activator Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of JNK Cascade Postsynaptic Modulation Of Chemical Synaptic Transmission Cellular Response To Fluid Shear Stress Regulation Of Metabolic Process Regulation Of Autophagy Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway	Intracellular Protein Transport Protein Import Into Nucleus Import Into Nucleus Establishment Of Protein Localization To Organelle Protein Localization To Nucleus Intracellular Transport Nuclear Transport Nucleocytoplasmic Transport Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding Cellular Localization Establishment Of Localization In Cell Protein Transport Establishment Of Protein Localization Nuclear Pore Small GTPase Binding Intracellular Protein Localization Protein Localization To Organelle Mating Behavior NLS-bearing Protein Import Into Nucleus Regulation Of Protein Localization To Nucleus Granulocyte Differentiation Reproductive Behavior Modulation Of Excitatory Postsynaptic Potential Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Learning Or Memory Amylin Binding Positive Regulation Of Toll Signaling Pathway RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Cognition Protein-containing Complex Acetylcholine Receptor Activator Activity Axo-dendritic Transport Lipoprotein Particle Positive Regulation Of Protein Import Negative Regulation Of Cell Cycle Response To Vitamin B2 C/EBP Complex Positive Regulation Of Viral Translation Regulation Of Defense Response PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development
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