RNGTT and AP3B1

		RNGTT	AP3B1
Description		RNA guanylyltransferase and 5'-phosphatase	adaptor related protein complex 3 subunit beta 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm	Mitochondrion Lysosomal Membrane Early Endosome Golgi Apparatus Membrane Membrane Coat AP-3 Adaptor Complex Clathrin Adaptor Complex Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Axon Cytoplasm Microvesicle
	Molecular Function	Nucleotide Binding Catalytic Activity MRNA Guanylyltransferase Activity Polynucleotide 5'-phosphatase Activity Phosphoprotein Phosphatase Activity Protein Binding ATP Binding GTP Binding RNA Guanylyltransferase Activity Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity Inorganic Triphosphate Phosphatase Activity MRNA 5'-triphosphate Monophosphatase Activity	Protein Binding Protein Phosphatase Binding GTP-dependent Protein Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process 7-methylguanosine MRNA Capping RNA Processing MRNA Processing	Cell Morphogenesis Toll-like Receptor Signaling Pathway Hematopoietic Progenitor Cell Differentiation Respiratory System Process Protein Targeting Protein Targeting To Lysosome Intracellular Zinc Ion Homeostasis Intracellular Protein Transport Inflammatory Response Lysosome Organization Spermatogenesis Single Fertilization Blood Coagulation Anterograde Axonal Transport Protein Transport Vesicle-mediated Transport Antigen Processing And Presentation Lung Development Granulocyte Differentiation Melanosome Organization Protein Localization To Cell Surface Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Protein Modification Process MRNA Transcription By RNA Polymerase II Pigmentation Positive Regulation Of Transcription By RNA Polymerase II Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Anterograde Synaptic Vesicle Transport Homeostasis Of Number Of Cells Positive Regulation Of NK T Cell Differentiation Platelet Dense Granule Organization Lung Morphogenesis Membrane Organization Establishment Of Protein Localization To Mitochondrial Membrane Involved In Mitochondrial Fission Skin Epidermis Development Melanosome Assembly
Pathways		RNA Pol II CTD phosphorylation and interaction with CE during HIV infection mRNA Capping RNA Pol II CTD phosphorylation and interaction with CE	Golgi Associated Vesicle Biogenesis Signaling by BRAF and RAF1 fusions
Drugs
Diseases			Hermansky-Pudlak syndrome (HPS)
GWAS		Colorectal or endometrial cancer ( 26621817) Depression in smokers ( 30219690) Graft survival time in renal transplantation (donor effect) ( 32080893) Height ( 31562340) Response to statin therapy ( 20339536) Simvastatin-induced myopathy ( 31220337) Subcutaneous adipose tissue ( 22589738)	Adult body size ( 32376654) Appendicular lean mass ( 33097823) Body size at age 10 ( 32376654) Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment ( 32472697) FEV1 ( 30804560) Hip circumference adjusted for BMI ( 34021172) Insulin resistance/response ( 21901158) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609 30804560) Metabolite levels ( 23823483) Red cell distribution width ( 32888494) Serum alkaline phosphatase levels ( 33547301) Triglycerides ( 26780889) Type 2 diabetes ( 31049640)
Interacting Genes		5 interacting genes: AP3B1 APPBP2 CEBPA CRYAA RNMT	18 interacting genes: AP3S2 ARF1 ARF5 ARF6 ARR3 ATM ATR BUB1 BUB1B CLTC CSNK1A1 CXADR FCGR2B GKAP1 RNGTT SLC30A3 SSBP2 ZER1
Entrez ID		8732	8546
HPRD ID		04621	04551
Ensembl ID		ENSG00000111880	ENSG00000132842
Uniprot IDs		B4DSJ8 O60942	A0A0S2Z5J4 A0A8Q3SIM7 O00203
PDB IDs		2C46 3S24 8P4A 8P4B 8P4C 8P4D 8P4E 8W8E 8W8F	9C58 9C59 9C5A 9C5B 9C5C
Enriched GO Terms of Interacting Partners?		Granulocyte Differentiation Mitochondrion Organization Lung Development RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Establishment Of Protein Localization To Mitochondrial Membrane Involved In Mitochondrial Fission MRNA Capping Enzyme Complex MRNA 5'-cap (guanine-N7-)-methyltransferase Activity MRNA Cap Methyltransferase RNMT:RAMAC Complex RNA 5'-cap (guanine-N7)-methylation Myeloid Leukocyte Differentiation CHOP-C/EBP Complex Response To Phenylpropanoid White Fat Cell Proliferation Myeloid Cell Differentiation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Lens Fiber Cell Morphogenesis Cell Morphogenesis Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Positive Regulation Of NK T Cell Differentiation Regulation Of NK T Cell Differentiation 7-methylguanosine MRNA Capping RNA (guanine-N7)-methylation Fat Cell Proliferation Microvesicle Leukocyte Differentiation Response To Lithium Ion Transcription By RNA Polymerase I Urea Metabolic Process Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion HMG Box Domain Binding RNA Metabolic Process Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Urea Cycle Interleukin-6-mediated Signaling Pathway Animal Organ Development Positive Regulation Of Cell Activation STAT Family Protein Binding Osteoblast Development Tubulin Complex Assembly Response To UV-A Embryonic Camera-type Eye Morphogenesis Lens Morphogenesis In Camera-type Eye Anterograde Synaptic Vesicle Transport AP-3 Adaptor Complex	Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Positive Regulation Of Telomerase Catalytic Core Complex Assembly Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Histone H2AXS139 Kinase Activity Meiotic Sister Chromatid Cohesion, Centromeric Negative Regulation Of Mitotic Nuclear Division Nucleotide Binding Negative Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Regulation Of Mitotic Sister Chromatid Separation Protein Serine/threonine Kinase Activity Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Cellular Component Organization Meiotic Sister Chromatid Cohesion Negative Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Separation Regulation Of Cell Cycle Process Negative Regulation Of Chromosome Organization Cell Division Negative Regulation Of Cell Cycle Phase Transition Spindle DNA Strand Resection Involved In Replication Fork Processing Vesicle-mediated Transport Regulation Of Chromosome Organization Replicative Senescence Regulation Of Cellular Response To Heat Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Organelle Organization Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Kinase Activity Negative Regulation Of B Cell Proliferation Negative Regulation Of Cell Cycle Process Positive Regulation Of Chromosome Organization Intracellular Protein Transport Regulation Of Sister Chromatid Segregation Protein Localization To Chromosome Outer Kinetochore Intracellular Protein Localization Regulation Of Mitotic Nuclear Division Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Segregation Kinase Activity Protein Localization To Site Of Double-strand Break Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cellular Component Organization Cellular Response To Gamma Radiation Chromosome Organization
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