PNPT1 and C2orf74

		PNPT1	C2orf74
Description		polyribonucleotide nucleotidyltransferase 1	chromosome 2 open reading frame 74
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Endoplasmic Reticulum Membrane Cytosol Ribosome Membrane Mitochondrial Degradosome Exoribonuclease Complex	Membrane
	Molecular Function	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding RNA Binding Nuclease Activity Exonuclease Activity Polyribonucleotide Nucleotidyltransferase Activity Protein Binding Poly(U) RNA Binding Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity Poly(G) Binding MiRNA Binding Identical Protein Binding	Protein Binding
	Biological Process	Mitochondrial RNA Catabolic Process Mitochondrial MRNA Catabolic Process Positive Regulation Of Mitochondrial RNA Catabolic Process Mitochondrial RNA 5'-end Processing Mitochondrial RNA 3'-end Processing RNA Processing MRNA Processing RNA Catabolic Process MRNA Catabolic Process Mitochondrion Organization Cellular Response To Oxidative Stress Cellular Response To Interferon-beta RNA Import Into Mitochondrion RRNA Import Into Mitochondrion Regulation Of Cellular Respiration Protein Homooligomerization Response To CAMP Response To Growth Hormone Positive Regulation Of MRNA Catabolic Process Protein Homotrimerization Nuclear Polyadenylation-dependent MRNA Catabolic Process Mitochondrial MRNA Polyadenylation Liver Regeneration Positive Regulation Of MiRNA Catabolic Process Regulation Of Cellular Senescence
Pathways		Mitochondrial RNA degradation
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Diastolic blood pressure ( 27618452) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935) Height ( 25429064 28552196 18391951) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 31959993 29617998) Medication use (antiglaucoma preparations and miotics) ( 31015401) Medication use (thyroid preparations) ( 31015401) Optic cup area ( 28073927) Pulse pressure ( 28135244 27841878) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 27618452) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for body mass index ( 28552196 34021172) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Crohn's disease ( 21102463 22412388) High light scatter reticulocyte percentage of red cells ( 32888494) Inflammatory bowel disease ( 23128233)
Interacting Genes		6 interacting genes: ADARB1 C2orf74 HSPB1 PRKRA RNF10 WDPCP	6 interacting genes: AHSA2P COMMD1 PNPT1 POT1 SMAGP TMEM17
Entrez ID		87178	339804
HPRD ID		18493	19550
Ensembl ID		ENSG00000138035	ENSG00000237651
Uniprot IDs		Q8TCS8	A8MZ97 C9JBF1
PDB IDs		3U1K 5ZF6 9KJR 9KJT
Enriched GO Terms of Interacting Partners?		Double-stranded RNA Binding Response To Virus Hypoglossal Nerve Morphogenesis Negative Regulation Of Protein Kinase C Signaling Axonemal Basal Plate Negative Regulation Of Cell Population Proliferation Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Double-stranded RNA Adenosine Deaminase Activity Regulation Of Cell Migration Deaminase Activity TRNA-specific Adenosine Deaminase Activity Adenosine To Inosine Editing Adenosine Deaminase Activity Spinal Cord Ventral Commissure Morphogenesis Facial Nerve Morphogenesis Regulation Of Protein Kinase C Signaling Microtubule-based Transport Transport Along Microtubule Anterograde Axonal Protein Transport Protein Kinase C Inhibitor Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Cytoskeleton-dependent Intracellular Transport RISC-loading Complex SiRNA Processing Sensory Organ Development Pre-miRNA Binding Outer Ear Morphogenesis Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Septin Cytoskeleton Organization Tongue Morphogenesis Podocyte Cell Migration Regulation Of Embryonic Cell Shape Respiratory System Development Auditory Receptor Cell Morphogenesis Digestive System Development RISC Complex Assembly Regulation Of Cell Motility SiRNA Binding Response To Other Organism Regulation Of Locomotion Cranial Nerve Morphogenesis Defense Response To Virus Neuromuscular Process Controlling Posture Positive Regulation Of Endothelial Cell Chemotaxis Protein Transport Along Microtubule Contractile Muscle Fiber Ear Development	Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Nuclear Polyadenylation-dependent MRNA Catabolic Process Polyribonucleotide Nucleotidyltransferase Activity Positive Regulation Of Cholesterol Import Positive Regulation Of Telomeric Loop Disassembly 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding RRNA Transport RRNA Import Into Mitochondrion Positive Regulation Of Mitochondrial RNA Catabolic Process Mitochondrial Degradosome Mitochondrial MRNA Catabolic Process Negative Regulation Of Hypoxia-inducible Factor-1alpha Signaling Pathway Positive Regulation Of Endosome To Plasma Membrane Protein Transport Telomeric D-loop Binding Telomere Assembly Mitochondrial MRNA Polyadenylation Mitochondrial RNA 5'-end Processing Regulation Of Plasma Lipoprotein Particle Levels Single-stranded Telomeric DNA Binding RNA Import Into Mitochondrion Regulation Of Cholesterol Import Shelterin Complex Mitochondrial RNA 3'-end Processing Exoribonuclease Complex Positive Regulation Of MiRNA Catabolic Process Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Mitochondrial RNA Catabolic Process DEAD/H-box RNA Helicase Binding Poly(G) Binding Sodium Channel Inhibitor Activity Positive Regulation Of Endocytic Recycling Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Negative Regulation Of Sodium Ion Transmembrane Transport G-rich Strand Telomeric DNA Binding Plasma Membrane To Endosome Transport Telomeric Loop Disassembly Telomere Capping Negative Regulation Of Protein Localization To Cell Surface MKS Complex Negative Regulation Of Cellular Response To Hypoxia Protein Homotrimerization Negative Regulation Of Sodium Ion Transport Response To Growth Hormone Low-density Lipoprotein Particle Clearance Regulation Of DNA Strand Elongation
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