HSD17B6 and PDE2A

		HSD17B6	PDE2A
Description		hydroxysteroid 17-beta dehydrogenase 6	phosphodiesterase 2A
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Membrane Early Endosome Membrane Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Membrane Presynaptic Membrane Perinuclear Region Of Cytoplasm Synaptic Membrane
	Molecular Function	Catalytic Activity Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity All-trans-retinol Dehydrogenase (NAD+) Activity Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Androsterone Dehydrogenase [NAD(P)+] Activity 5-alpha-androstane-3-beta,17-beta-diol Dehydrogenase (NADP+) Activity Testosterone Dehydrogenase (NAD+) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity Testosterone Dehydrogenase (NADP+) Activity	Nucleotide Binding Magnesium Ion Binding 3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity 3',5'-cGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Zinc Ion Binding Hydrolase Activity CAMP Binding CGMP Binding TPR Domain Binding Phosphate Ion Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Lipid Metabolic Process Androgen Biosynthetic Process Androgen Catabolic Process Steroid Metabolic Process Retinol Metabolic Process Brexanolone Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Heart Valve Development Ventricular Septum Development Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Regulation Of CGMP-mediated Signaling Negative Regulation Of CGMP-mediated Signaling Regulation Of Mitochondrion Organization CGMP-mediated Signaling Monocyte Differentiation Aorta Development Cellular Response To Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Vascular Permeability Positive Regulation Of Vascular Permeability CGMP Catabolic Process Positive Regulation Of Inflammatory Response Establishment Of Endothelial Barrier Cellular Response To Mechanical Stimulus Cellular Response To CAMP Cellular Response To CGMP Cellular Response To Xenobiotic Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of CAMP/PKA Signal Transduction Cellular Response To 2,3,7,8-tetrachlorodibenzodioxine
Pathways		The canonical retinoid cycle in rods (twilight vision)	cGMP effects G alpha (s) signalling events
Drugs			Caffeine Cyclic GMP ND7001 ND7001 Exisulind 3-isobutyl-1-methyl-7H-xanthine Tofisopam Doxofylline Trapidil
Diseases
GWAS		Asthma ( 31619474) Cerebral amyloid deposition (PET imaging) ( 30361487) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Platelet aggregation ( 20526338) Platelet count ( 27863252) Red blood cell count ( 29403010)	Household income (MTAG) ( 31844048) Optic nerve measurement (cup area) ( 20395239) Rheumatoid arthritis ( 22446963)
Interacting Genes		1 interacting genes: PDE2A	13 interacting genes: ANAPC15 CHEK1 FAM168A FCHSD2 FOLR1 GLS2 HSD17B6 ITSN1 LRP5 NDUFV1 RPS3 RPS6KA4 SPAG7
Entrez ID		8630	5138
HPRD ID		09431	04041
Ensembl ID		ENSG00000025423	ENSG00000186642
Uniprot IDs		A0A219K5H4 A0A219K684 O14756	O00408 Q8IW54
PDB IDs			1Z1L 3IBJ 3ITM 3ITU 4C1I 4D08 4D09 4HTX 4HTZ 4JIB 5TZ3 5TZA 5TZC 5TZH 5TZW 5TZX 5TZZ 5U00 5U7D 5U7I 5U7J 5U7K 5U7L 5VP0 5VP1 5XKM 6B96 6B97 6B98 6BLF 6C7D 6C7E 6C7F 6C7G 6C7I 6C7J 6CYB 6CYC 6CYD 6ZND 6ZQZ
Enriched GO Terms of Interacting Partners?		Cellular Response To CGMP 3',5'-cyclic-AMP Phosphodiesterase Activity CGMP Metabolic Process Cyclic Nucleotide Catabolic Process 3',5'-cGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cellular Response To Macrophage Colony-stimulating Factor Stimulus Response To Macrophage Colony-stimulating Factor Negative Regulation Of CGMP-mediated Signaling 3',5'-cyclic-GMP Phosphodiesterase Activity Phosphate Ion Binding Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus CAMP Binding CGMP Catabolic Process TPR Domain Binding Regulation Of CGMP-mediated Signaling Monocyte Differentiation 3',5'-cyclic-nucleotide Phosphodiesterase Activity Response To 2,3,7,8-tetrachlorodibenzodioxine CGMP Binding Cellular Response To 2,3,7,8-tetrachlorodibenzodioxine Positive Regulation Of Vascular Permeability Negative Regulation Of Vascular Permeability Response To CGMP Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Valve Development Negative Regulation Of CAMP/PKA Signal Transduction CGMP-mediated Signaling Aorta Development Ventricular Septum Development Establishment Of Endothelial Barrier Cyclic Purine Nucleotide Metabolic Process Artery Development Cardiac Septum Development Regulation Of Vascular Permeability Regulation Of CAMP/PKA Signal Transduction Endothelial Cell Development Phosphoric Diester Hydrolase Activity Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Cellular Response To CAMP Cellular Response To Transforming Growth Factor Beta Stimulus Synaptic Membrane Cellular Response To Xenobiotic Stimulus Response To Transforming Growth Factor Beta Cellular Response To Mechanical Stimulus Purine Ribonucleotide Catabolic Process Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Purine Nucleotide Catabolic Process Response To CAMP Nucleotide Catabolic Process	Positive Regulation Of Base-excision Repair Regulation Of Base-excision Repair Regulation Of Mitotic Nuclear Division Apoptotic Process Involved In Development Regulation Of Nuclear Division Endocytosis Receptor-mediated Endocytosis Clathrin-dependent Endocytosis Regulation Of DNA Repair Neural Crest Cell Migration Involved In Heart Formation Response To TNF Agonist Oxidized Pyrimidine DNA Binding Brexanolone Catabolic Process Stereocilium Shaft
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