ACTL6A and ERO1B

		ACTL6A	ERO1B
Description		actin like 6A	endoplasmic reticulum oxidoreductase 1 beta
Image			No pdb structure
GO Annotations	Cellular Component	Kinetochore Chromatin Nucleosome Nucleus Nucleoplasm Plasma Membrane Nuclear Matrix SWI/SNF Complex RSC-type Complex Ino80 Complex Protein-containing Complex Brahma Complex NuA4 Histone Acetyltransferase Complex NpBAF Complex GBAF Complex	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Protein Binding Nucleosomal DNA Binding	Protein Binding Protein-disulfide Reductase Activity Disulfide Oxidoreductase Activity Oxidoreductase Activity Thiol Oxidase Activity Unfolded Protein Binding FAD Binding
	Biological Process	Telomere Maintenance Blastocyst Formation Neural Retina Development Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Signal Transduction Nervous System Development Positive Regulation Of Cell Population Proliferation Spinal Cord Development Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Organization Regulation Of Apoptotic Process Positive Regulation Of T Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Regulation Of Embryonic Development System Development Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Regulation Of G0 To G1 Transition Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Telomere Maintenance In Response To DNA Damage Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Double-strand Break Repair Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair	Protein Folding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Insulin Processing Extracellular Matrix Organization Protein Folding In Endoplasmic Reticulum Glucose Homeostasis Cell Redox Homeostasis Protein Maturation
Pathways		HATs acetylate histones RMTs methylate histone arginines UCH proteinases DNA Damage Recognition in GG-NER RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	Insulin processing
Drugs			1-Ethyl-Pyrrolidine-2,5-Dione Flavin adenine dinucleotide
Diseases
GWAS		Pars opercularis volume ( 31530798)
Interacting Genes		17 interacting genes: ARHGDIA CDK2 CDK9 ERO1B EWSR1 FLII MRGBP MYC OGT POLR2A PTEN RELA RUVBL1 SMARCA2 SMARCA4 TRRAP UBC	11 interacting genes: ACTL6A BRCA1 CNRIP1 ERP44 GNG4 HMGCS2 OGT P4HB PARVA PYGM TARBP1
Entrez ID		86	56605
HPRD ID		05389	13279
Ensembl ID		ENSG00000136518	ENSG00000086619
Uniprot IDs		O96019	Q86YB8
PDB IDs		6LTJ 7VDV 7Y8R 8QR1 8X15 8X19 8X1C 8XVG 8XVT 9C4B 9C57 9C62 9C6N
Enriched GO Terms of Interacting Partners?		Chromatin Organization Positive Regulation Of DNA Metabolic Process Regulation Of DNA Metabolic Process Nucleoplasm Positive Regulation Of Double-strand Break Repair Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of DNA Repair Positive Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Positive Regulation Of DNA Repair Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Double-strand Break Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Response To Stress Positive Regulation Of Biosynthetic Process Regulation Of Stem Cell Population Maintenance Regulation Of RNA Metabolic Process Nucleus Chromatin Remodeling Regulation Of Nucleobase-containing Compound Metabolic Process NuA4 Histone Acetyltransferase Complex Regulation Of Transcription By RNA Polymerase II Regulation Of Chromosome Organization Positive Regulation Of Macromolecule Metabolic Process ATP-dependent Activity, Acting On DNA Nucleosome Array Spacer Activity Positive Regulation Of Metabolic Process Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Stem Cell Population Maintenance Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of MiRNA Transcription Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of MiRNA Metabolic Process Regulation Of Gene Expression BBAF Complex DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Transcription Positive Regulation Of DNA Recombination Regulation Of Primary Metabolic Process Swr1 Complex Regulation Of Double-strand Break Repair Via Homologous Recombination NpBAF Complex GBAF Complex Regulation Of MiRNA Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II
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