KCNAB2 and FAM3B

		KCNAB2	FAM3B
Description		potassium voltage-gated channel subfamily A regulatory beta subunit 2	FAM3 metabolism regulating signaling molecule B
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Microtubule Plasma Membrane Voltage-gated Potassium Channel Complex Cytoplasmic Side Of Plasma Membrane Membrane Axon Specific Granule Membrane Cell Projection Neuron Projection Juxtaparanode Region Of Axon Synapse Tertiary Granule Membrane Pinceau Fiber	Extracellular Region Extracellular Space Extracellular Exosome
	Molecular Function	Voltage-gated Potassium Channel Activity Protein Binding Alcohol Dehydrogenase (NADP+) Activity Potassium Channel Regulator Activity Oxidoreductase Activity Transmembrane Transporter Binding Methylglyoxal Reductase (NADPH) (acetol Producing) Activity	Cytokine Activity Protein Binding Carbohydrate Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Protein Localization To Cell Surface	Apoptotic Process Signal Transduction Insulin Secretion
Pathways		Voltage gated Potassium channels Neutrophil degranulation
Drugs		Enflurane Promethazine Miconazole
Diseases
GWAS		Metabolite levels ( 23823483)	Blood protein levels ( 30072576) Elevated serum carcinoembryonic antigen levels ( 24941225) Glycemic traits (pregnancy) ( 23903356) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Tumor biomarkers ( 23300138)
Interacting Genes		12 interacting genes: ATXN1 CD4 CEBPA FAM3B KCNA2 LCOR NEDD4 NEDD4L SLC39A1 SLC39A2 SQSTM1 TNFRSF18	7 interacting genes: APP BIN2 COL6A1 FCGR2A H2BC12L KCNAB2 MAP3K7CL
Entrez ID		8514	54097
HPRD ID		03090	10552
Ensembl ID		ENSG00000069424	ENSG00000183844
Uniprot IDs		B2R776 Q13303	P58499
PDB IDs		1ZSX 7EJ1 7EJ2 7WF3 7WF4
Enriched GO Terms of Interacting Partners?		Fat Cell Proliferation Sodium Channel Inhibitor Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Potassium Channel Inhibitor Activity Metal Ion Transport Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Transport Monoatomic Cation Transport Receptor Catabolic Process Negative Regulation Of Potassium Ion Transmembrane Transport Metal Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transporter Activity Positive Regulation Of Protein Metabolic Process DNA-templated Transcription Zinc Ion Transport Zinc Ion Transmembrane Transport Regulation Of Membrane Potential Ionotropic Glutamate Receptor Binding Negative Regulation Of Potassium Ion Transport Monoatomic Ion Transport Regulation Of Protein Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Neuromuscular Junction Development Positive Regulation Of Protein Catabolic Process Macrophage Differentiation Positive Regulation Of Catabolic Process Receptor Metabolic Process Interleukin-16 Binding Regulation Of Biological Quality Interleukin-16 Receptor Activity Helper T Cell Enhancement Of Adaptive Immune Response Regulation Of Monoatomic Cation Transmembrane Transport RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Protein Targeting To Vacuole Protein Monoubiquitination Formation Of Structure Involved In A Symbiotic Process Protein Polyubiquitination Regulation Of Dendrite Morphogenesis Establishment Of Protein Localization To Vacuole Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Transcription By RNA Polymerase II Inorganic Ion Transmembrane Transport Energy Homeostasis Negative Regulation Of Cation Transmembrane Transport Regulation Of Sodium Ion Transport Receptor Internalization Response To Methamphetamine Hydrochloride	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Regulation Of Response To Calcium Ion Positive Regulation Of Tumor Necrosis Factor Production Amylin Binding Endosome To Plasma Membrane Transport Vesicle Antibacterial Humoral Response Protein Tetramerization Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Defense Response To Gram-positive Bacterium Defense Response Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Locomotion Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Collagen Type VI Trimer Multicellular Organismal Locomotion Response To Polyamine Macromolecule Pinceau Fiber Methylglyoxal Reductase (NADPH) (acetol Producing) Activity Regulation Of Spontaneous Synaptic Transmission Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Regulation Of Tumor Necrosis Factor Production NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Endocytosis Cellular Response To Norepinephrine Stimulus Regulation Of Toll Signaling Pathway Growth Factor Receptor Binding Main Axon Antimicrobial Humoral Response Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Response To Bleomycin Apoptotic Nuclear Changes Skeletal Muscle Tissue Growth
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