RAE1 and AQP7

		RAE1	AQP7
Description		ribonucleic acid export 1	aquaporin 7
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GO Annotations	Cellular Component	Spindle Pole Fibrillar Center Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytoskeleton Mitotic Spindle Pole	Cytoplasm Lipid Droplet Plasma Membrane Cell-cell Junction Membrane Basolateral Plasma Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	RNA Binding Protein Binding Microtubule Binding Ubiquitin Binding	Protein Binding Urea Transmembrane Transporter Activity Water Channel Activity Glycerol Channel Activity Channel Activity
	Biological Process	Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery RNA Export From Nucleus MRNA Export From Nucleus Nucleocytoplasmic Transport Cell Division Regulation Of Mitotic Spindle Organization	Water Transport Glycerol Transmembrane Transport Transmembrane Transport Urea Transmembrane Transport
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses	Transport of glycerol from adipocytes to the liver by Aquaporins Passive transport by Aquaporins
Drugs
Diseases
GWAS			Lung adenocarcinoma ( 28604730) Urinary albumin excretion ( 30220432)
Interacting Genes		22 interacting genes: AQP7 BDKRB1 BUB1 CASS4 CEBPA CREBRF DDX24 DHFR EIF4ENIF1 FZD8 HPCA HTR2B KLRC4 KLRK1 NUMA1 NUP98 NXF1 PCK1 RBM38 RNU1-1 RTEL1 TRF-GAA1-1	5 interacting genes: ABHD16A CLCN7 COMT MFSD6 RAE1
Entrez ID		8480	364
HPRD ID		11939	04277
Ensembl ID		ENSG00000101146	ENSG00000165269
Uniprot IDs		P78406	B7Z4U2 O14520 Q5T5M0 Q6P5T0
PDB IDs		3MMY 4OWR 7F60 7F90 7VPG 7VPH	6KXW 6N1G 6QZI 6QZJ 8AMW 8AMX 8C9H
Enriched GO Terms of Interacting Partners?		MRNA Binding Positive Regulation Of Chromosome Organization Kinase Binding Nuclear Transport Nucleocytoplasmic Transport Nuclear Inclusion Body Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Peptide Binding Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Methotrexate Cortical Microtubule Anastral Spindle Assembly Cytoplasmic Microtubule Bundle Positive Regulation Of Protein Localization To Spindle Pole Body Positive Regulation Of Mitotic Spindle Elongation Nuclear Export Telomere Tethering At Nuclear Periphery Import Into Nucleus Protein Import Into Nucleus Protein Serine Kinase Activity (using GTP As Donor) Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity DNA Strand Displacement Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Positive Regulation Of Prolactin Signaling Pathway Response To Dexamethasone Protein Localization To Nucleus	Chloride:proton Antiporter Activity Cellular Response To Phosphate Starvation Norepinephrine Secretion Catechol O-methyltransferase Activity Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Transepithelial Chloride Transport O-methyltransferase Activity Renal Tubular Secretion Dopamine Secretion Habituation Renal Protein Absorption Mastication Catecholamine Catabolic Process Renal Sodium Excretion Renal Albumin Absorption Norepinephrine Transport Nonassociative Learning Renin Secretion Into Blood Stream Cellular Response To Cocaine Response To Dopamine Dopamine Catabolic Process Catecholamine Secretion Cerebellar Cortex Morphogenesis Monoacylglycerol Catabolic Process Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Monoacylglycerol Lipase Activity Synaptic Transmission, Dopaminergic Glomerulus Development Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Norepinephrine Metabolic Process Startle Response Response To Corticosterone Phosphatidylserine Metabolic Process Chloride Transmembrane Transporter Activity Renal Filtration Dopamine Transport Response To Catecholamine Detection Of Temperature Stimulus Involved In Sensory Perception Phosphatidylcholine Lysophospholipase Activity Detection Of Temperature Stimulus Response To Salt Glycerophospholipid Catabolic Process Response To Angiotensin Phospholipase Activity Acylglycerol Catabolic Process Cholesterol Efflux Monoamine Transport Dopamine Metabolic Process
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