CAT and CD44

		CAT	CD44
Description		catalase	CD44 molecule (IN blood group)
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Mitochondrion Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol Focal Adhesion Membrane Protein-containing Complex Secretory Granule Lumen Catalase Complex Extracellular Exosome Ficolin-1-rich Granule Lumen	Extracellular Region Golgi Apparatus Cytosol Plasma Membrane Microvillus Focal Adhesion Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Secretory Granule Membrane Lamellipodium Membrane Protein-containing Complex Macrophage Migration Inhibitory Factor Receptor Complex Cell Projection Extracellular Exosome
	Molecular Function	Aminoacylase Activity Catalase Activity Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor Enzyme Binding Heme Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding NADP Binding	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Collagen Binding Hyaluronic Acid Binding
	Biological Process	Response To Reactive Oxygen Species Osteoblast Differentiation Ureteric Bud Development Response To Hypoxia Kidney Development Triglyceride Metabolic Process Response To Oxidative Stress Cholesterol Metabolic Process Aerobic Respiration Response To Xenobiotic Stimulus Response To UV Response To Toxic Substance Response To Light Intensity UV Protection Response To Ozone Response To Lead Ion Response To Activity Response To Inactivity Hemoglobin Metabolic Process Response To Estradiol Response To Insulin Response To Vitamin A Response To Vitamin E Response To L-ascorbic Acid Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Response To Ethanol Response To Cadmium Ion Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Hyperoxia Cellular Detoxification Of Hydrogen Peroxide Response To Fatty Acid Cellular Response To Growth Factor Stimulus Response To Amitrole Response To Phenylpropanoid	Inflammatory Response Cell Adhesion Cell-matrix Adhesion Anatomical Structure Morphogenesis Cell Migration Cytokine-mediated Signaling Pathway Hyaluronan Catabolic Process Positive Regulation Of Heterotypic Cell-cell Adhesion T Cell Activation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Wound Healing, Spreading Of Cells Cellular Response To Fibroblast Growth Factor Stimulus System Development Cartilage Development Positive Regulation Of ERK1 And ERK2 Cascade Monocyte Aggregation Cell-cell Adhesion Positive Regulation Of Monocyte Aggregation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Lamellipodium Morphogenesis
Pathways		Detoxification of Reactive Oxygen Species Neutrophil degranulation Peroxisomal protein import Peroxisomal protein import FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Mitochondrial unfolded protein response (UPRmt)	Degradation of the extracellular matrix Cell surface interactions at the vascular wall Hyaluronan metabolism Integrin cell surface interactions Hyaluronan degradation Neutrophil degranulation Interferon gamma signaling Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells
Drugs		Fomepizole Cannabidiol Benzoyl peroxide Medical Cannabis Nabiximols	Bivatuzumab Hyaluronic acid
Diseases		Acatalasia, including: Acatalasemia; Takahara's disease; Hypocatalasemia	Gastric cancer
GWAS		Blood protein levels ( 30072576)	Bone mineral density (hip) ( 30172743) Glycemic traits (pleiotropy) ( 31021400) Intake of sweets ( 31005972) Response to Vitamin E supplementation ( 22437554) Systemic lupus erythematosus ( 23273568 26502338 27399966 28714469) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Total body bone mineral density ( 29304378) Uterine fibroids ( 31649266) Vitiligo ( 22561518 27723757)
Interacting Genes		11 interacting genes: ABL1 ABL2 APP CD44 EHHADH KEAP1 OGT PRKRA PTPN11 SUMO4 TLR10	70 interacting genes: ABCB1 ABCB5 AKT1 ANK1 ANXA1 ARHGEF1 ARHGEF12 ARNT BDNF CAT CCND2 CD4 CD74 CDK4 CDK6 CDKN2A CDKN2B COL14A1 COL1A1 COL1A2 CSK CSTF3 DMP1 DPT EGFR EPB41 EPHA2 ERBB4 EZR FGF2 FGFR4 FN1 FYN GARS1 GLIS2 GRM1 HBEGF HMMR IGFBP3 KDELR2 LATS2 LCK LMO2 MADCAM1 MAP2K3 MAP2K5 MAP3K13 MDM4 MET MMP1 MMP7 MMP9 NF2 NONO PDGFRA PKN1 RAF1 RIMS2 SELE SPP1 SRC SRD5A1 SRGN STK11 TGFBR1 TGFBR2 TIAM1 VAV2 VCAN VHL
Entrez ID		847	960
HPRD ID		00282	00115
Ensembl ID		ENSG00000121691	ENSG00000026508
Uniprot IDs		A0A384P5Q0 P04040	P16070
PDB IDs		1DGB 1DGF 1DGG 1DGH 1F4J 1QQW 7P8W 7VD9 8EL9 8HID 8PVD 8SGV 8WZH 8WZJ 8WZK 8WZM	1POZ 1UUH 2I83 4PZ3 4PZ4 6TXS
Enriched GO Terms of Interacting Partners?		Cellular Response To Oxidative Stress Cellular Response To Chemical Stress Response To Stress Positive Regulation Of T Cell Migration Enzyme Binding Phosphotyrosine Residue Binding Protein-containing Complex Positive Regulation Of Establishment Of T Cell Polarity Positive Regulation Of Lymphocyte Migration Regulation Of T Cell Migration Regulation Of Intracellular Signal Transduction Response To Oxidative Stress Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Establishment Of T Cell Polarity Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Lymphocyte Migration ERBB Signaling Pathway Enzyme Activator Activity Bergmann Glial Cell Differentiation Cellular Response To Growth Factor Stimulus Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Intracellular Signal Transduction Response To Growth Factor Positive Regulation Of Cell-cell Adhesion Cellular Response To Catecholamine Stimulus Positive Regulation Of Mitotic Cell Cycle Response To Catecholamine Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell Activation Regulation Of Signal Transduction Regulation Of Mononuclear Cell Migration Regulation Of Establishment Of Cell Polarity Insulin Receptor Binding Positive Regulation Of Leukocyte Migration Actin Monomer Binding Cell Activation Involved In Immune Response Regulation Of Establishment Or Maintenance Of Cell Polarity Positive Regulation Of MAPK Cascade Ephrin Receptor Binding Negative Regulation Of Signaling Negative Regulation Of Cell Communication Hemopoiesis Cellular Response To Stress Astrocyte Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Signal Transduction Regulation Of Intrinsic Apoptotic Signaling Pathway	Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Motility Regulation Of Cell Communication Regulation Of Signaling Kinase Activity Regulation Of Locomotion Regulation Of Cell Population Proliferation Regulation Of Developmental Process Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Motility Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Positive Regulation Of Locomotion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Differentiation Intracellular Signal Transduction Protein Phosphorylation Animal Organ Development Developmental Process Regulation Of Growth Cellular Developmental Process Response To Growth Factor Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Modification Process ATP Binding Cellular Response To Growth Factor Stimulus Regulation Of MAPK Cascade Regulation Of Multicellular Organismal Development Regulation Of Cell Differentiation Regulation Of Phosphorylation Positive Regulation Of Developmental Process Cell Migration Positive Regulation Of Cell Population Proliferation Positive Regulation Of Growth Regulation Of Cell Growth Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Differentiation Regulation Of Programmed Cell Death
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