DOC2A and TUFM

		DOC2A	TUFM
Description		double C2 domain alpha	Tu translation elongation factor, mitochondrial
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GO Annotations	Cellular Component	Lysosome Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuron Projection Synapse Extrinsic Component Of Synaptic Vesicle Membrane Glutamatergic Synapse	Mitochondrion Mitochondrial Outer Membrane Membrane Mitochondrial Nucleoid Extracellular Exosome
	Molecular Function	Protein Binding Calcium-dependent Phospholipid Binding Metal Ion Binding	Nucleotide Binding Magnesium Ion Binding RNA Binding Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Exocytosis Chemical Synaptic Transmission Nervous System Development Synaptic Vesicle Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Spontaneous Neurotransmitter Secretion Calcium-dependent Activation Of Synaptic Vesicle Fusion	Translation Translational Elongation Mitochondrial Translational Elongation
Pathways			Mitochondrial translation elongation SARS-CoV-2 modulates autophagy
Drugs			Zinc Guanosine-5'-Diphosphate Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Combined oxidative phosphorylation deficiency (COXPD)
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Height ( 28552196) Schizophrenia ( 25056061 28991256 29483656)	Alcohol consumption (drinks per week) ( 30643258) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat percentage ( 26833246) Body mass index ( 20935630) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 28067908) Educational attainment ( 25201988) Estimated glomerular filtration rate ( 31152163) Extremely high intelligence ( 29520040) Hip circumference adjusted for BMI ( 25673412) Inflammatory bowel disease ( 28067908) Intelligence ( 28530673) Lamb consumption ( 32066663) Walking pace ( 33128006)
Interacting Genes		6 interacting genes: DYNLT1 FOXP1 RAP1GDS1 STXBP1 UBASH3B UNC13B	20 interacting genes: ARL6IP1 ASPH ATP6V1A CMTM5 DGAT2L6 EXOSC6 FAM9B FUNDC1 HMBOX1 LINC01554 MTIF3 MYH9 OGT PCAT1 PTEN RHBDD2 SYP TNFRSF10D XIAP ZDHHC15
Entrez ID		8448	7284
HPRD ID		05195	03861
Ensembl ID		ENSG00000149927	ENSG00000178952
Uniprot IDs		Q14183	A0A384ME17 P49411
PDB IDs		4MJJ	7A5G 7O9K
Enriched GO Terms of Interacting Partners?		Dense Core Granule Exocytosis Neuronal Dense Core Vesicle Exocytosis Regulation Of Synaptic Vesicle Priming Syntaxin-1 Binding Synaptic Vesicle Priming Negative Regulation Of Cell Differentiation Secretory Granule Localization Nuclear Androgen Receptor Binding Calcium-ion Regulated Exocytosis Negative Regulation Of Developmental Process Vesicle Docking Involved In Exocytosis Regulation Of Cell Communication Regulation Of Signaling CAAX-box Protein Maturation Platelet Aggregation Positive Regulation Of Vesicle Docking Transport Of Viral Material Towards Nucleus Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Positive Regulation Of Synaptic Vesicle Priming Establishment Of Organelle Localization Negative Regulation Of Cell Development Vesicle Docking Homotypic Cell-cell Adhesion Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Organelle Localization By Membrane Tethering Intracellular Transport Of Viral Protein In Host Cell Dense Core Granule Priming Positive Regulation Of Interleukin-21 Production Membrane Docking Regulation Of Signal Transduction Axon Target Recognition Regulation Of Acrosomal Vesicle Exocytosis Regulation Of Cell Development Negative Regulation Of Neuron Maturation Basal Dendrite Morphogenesis Basal Dendrite Arborization Regulated Exocytosis Establishment Of Vesicle Localization Myosin Filament Assembly Extrinsic Component Of Presynaptic Membrane Presynaptic Dense Core Vesicle Exocytosis Positive Regulation Of Glutamate Secretion, Neurotransmission Negative Regulation Of Synaptic Transmission, GABAergic Regulation Of Cell Differentiation [heparan Sulfate]-glucosamine 3-sulfotransferase Activity Regulation Of Transport Platelet Degranulation Vesicle Localization Regulation Of Glutamate Secretion, Neurotransmission
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