C22orf46P and CENPM

		C22orf46P	CENPM
Description		CTA-216E10.6	centromere protein M
Image		No pdb structure
GO Annotations	Cellular Component		Chromosome, Centromeric Region Kinetochore Inner Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol
	Molecular Function
	Biological Process		Chromosome Segregation
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Birth weight ( 23202124) Processed meat consumption ( 32066663) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		4 interacting genes: APP CENPM KRT40 SMAD2	7 interacting genes: C22orf46P CCDC134 CENPS DESI1 H3C1 PHF5A SEPTIN3
Entrez ID		79640	79019
HPRD ID		08037	12798
Ensembl ID		ENSG00000293428	ENSG00000100162
Uniprot IDs			B1AHQ6 B1AHQ7 B1AHQ8 Q9NSP4
PDB IDs			4P0T 4WAU 7PKN 7QOO 7R5S 7R5V 7XHN 7XHO 7YWX 7YYH
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Zygotic Specification Of Dorsal/ventral Axis Activin Responsive Factor Complex Homomeric SMAD Protein Complex Paraxial Mesoderm Morphogenesis Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Mesoderm Morphogenesis Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Pericardium Development Axon Choice Point Recognition Odontoblast Differentiation SMAD Protein Complex Trophoblast Cell Migration Heparan Sulfate Binding Signaling Receptor Activator Activity Heteromeric SMAD Protein Complex Peptidase Activator Activity Response To Growth Factor Cellular Response To Manganese Ion Determination Of Left/right Asymmetry In Lateral Mesoderm Anatomical Structure Morphogenesis Embryonic Foregut Morphogenesis
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