THTPA and PDE6B

		THTPA	PDE6B
Description		thiamine triphosphatase	phosphodiesterase 6B
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Photoreceptor Outer Segment Plasma Membrane Membrane Photoreceptor Outer Segment Membrane Cell Projection Photoreceptor Disc Membrane
	Molecular Function	Magnesium Ion Binding Protein Binding Hydrolase Activity Metal Ion Binding Thiamine Triphosphate Phosphatase Activity	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Phosphoric Diester Hydrolase Activity Hydrolase Activity Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Generation Of Precursor Metabolites And Energy Thiamine Metabolic Process Phosphate-containing Compound Metabolic Process Thiamine Diphosphate Biosynthetic Process Dephosphorylation Thiamine Diphosphate Metabolic Process Thiamine-containing Compound Metabolic Process	Signal Transduction Visual Perception Phototransduction, Visible Light Detection Of Light Stimulus Entrainment Of Circadian Clock By Photoperiod Retina Development In Camera-type Eye Negative Regulation Of CAMP/PKA Signal Transduction Retinal Cell Apoptotic Process
Pathways		Vitamin B1 (thiamin) metabolism	Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Ca2+ pathway Ca2+ pathway
Drugs			Caffeine Trapidil
Diseases			Congenital stationary night blindness (CSNB), including: CSNB type 1 (CSNB1); CSNB type 2 (CSNB2); CSNB autosomal dominant (CSNBAD); Oguchi disease/ CSNB Oguchi type (CSNBO) Retinitis pigmentosa (RP)
GWAS
Interacting Genes		8 interacting genes: DPAGT1 GCDH HEY1 METTL17 OR4K5 PDE6B RNASE7 TLX3	2 interacting genes: GLA THTPA
Entrez ID		79178	5158
HPRD ID		15505	01571
Ensembl ID		ENSG00000259431	ENSG00000133256
Uniprot IDs		G3V5Q5 Q9BU02	B4DHV7 P35913
PDB IDs		3BHD 3TVL
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Nitric-oxide Synthase Activity Alpha-galactosidase Activity Thiamine Triphosphate Phosphatase Activity Thiamine Diphosphate Metabolic Process Thiamine Diphosphate Biosynthetic Process Thiamine Metabolic Process Glycosylceramide Catabolic Process Regulation Of Nitric-oxide Synthase Activity Glycoside Catabolic Process Negative Regulation Of Oxidoreductase Activity Thiamine-containing Compound Metabolic Process Glycosylceramide Metabolic Process Glycosphingolipid Catabolic Process Ceramide Catabolic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Oxidoreductase Activity Glycolipid Catabolic Process Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Vitamin Metabolic Process Sphingolipid Catabolic Process Pyrimidine-containing Compound Biosynthetic Process Membrane Lipid Catabolic Process Glycosphingolipid Metabolic Process Oligosaccharide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Hydrolase Activity, Acting On Glycosyl Bonds Pyrimidine-containing Compound Metabolic Process Hydrolase Activity Glycolipid Metabolic Process Ceramide Metabolic Process Azurophil Granule Lumen Lysosomal Lumen Sulfur Compound Biosynthetic Process Dephosphorylation Sphingolipid Metabolic Process Negative Regulation Of Catalytic Activity Carbohydrate Derivative Catabolic Process Membrane Lipid Metabolic Process Magnesium Ion Binding
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