PRDM2 and TBCE

		PRDM2	TBCE
Description		PR/SET domain 2	tubulin folding cofactor E
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Golgi Apparatus	Cytoplasm Cytoskeleton Microtubule
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Sequence-specific DNA Binding Metal Ion Binding Histone H3K9 Trimethyltransferase Activity	Protein Binding Alpha-tubulin Binding Protein-folding Chaperone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Determination Of Adult Lifespan Methylation Positive Regulation Of Transcription By RNA Polymerase II	Microtubule Cytoskeleton Organization Protein Folding Tubulin Complex Assembly Post-chaperonin Tubulin Folding Pathway Mitotic Spindle Organization Axonogenesis Adult Locomotory Behavior Post-embryonic Development Muscle Atrophy Developmental Growth Peripheral Nervous System Neuron Axonogenesis
Pathways			Post-chaperonin tubulin folding pathway
Drugs
Diseases			Kenny-Caffey syndrome Hypoparathyroidism-retardation-dysmorphism syndrome; Sanjad-Sakati syndrome
GWAS		Anti-drug antibodies in autoimmune disease (time to event) ( 33125391) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Chronotype ( 30696823) Copper levels ( 26025379) HDL cholesterol levels in HIV infection ( 33109212) Intracranial aneurysm ( 30823506) Left ventricular function change in anthracycline treatment ( 28542097) Logical memory (delayed recall) in Alzheimer's disease dementia ( 29274321) Parkinson's disease ( 26227905) Polycystic ovary syndrome (reproductive subtype) ( 32574161) Refractive error ( 32231278) Schizophrenia x sex interaction ( 34099189)	Adiposity ( 19557161) Blood protein levels ( 30072576) First year height change in growth hormone-treated short stature ( 32652002) Household income (MTAG) ( 31844048)
Interacting Genes		9 interacting genes: BBS5 E2F1 ESR1 H3-4 H3C1 MDM2 PDPN RB1 TBCE	7 interacting genes: AKT1 EIF2B2 OGT PRDM2 SERTAD3 TBCD TUBA4A
Entrez ID		7799	6905
HPRD ID		03120	05381
Ensembl ID		ENSG00000116731	ENSG00000284770
Uniprot IDs		Q13029	A0A2R8Y6Q1 Q15813
PDB IDs		2JV0 2QPW	4ICU 4ICV
Enriched GO Terms of Interacting Partners?		Rb-E2F Complex Cellular Response To Estrogen Stimulus Anatomical Structure Morphogenesis Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein-DNA Complex Assembly Disordered Domain Specific Binding Positive Regulation Of Extracellular Matrix Organization Transcription Regulator Complex Regulation Of Glial Cell Proliferation Chromatin Remodeling Protein-containing Complex Assembly Epithelial Cell Apoptotic Process Regulation Of DNA Binding Response To Xenobiotic Stimulus Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Fibroblast Proliferation Cellular Response To Xenobiotic Stimulus Protein-containing Complex Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Differentiation Regulation Of Developmental Process Regulation Of Epithelial Cell Apoptotic Process Protein-containing Complex Organization Response To Estrogen Cellular Component Assembly Chromatin Organization Cellular Response To Hormone Stimulus Response To Formaldehyde Cellular Response To Vitamin B1 Heart Valve Morphogenesis Regulation Of Extracellular Matrix Organization Cellular Response To Oxygen-containing Compound Positive Regulation Of Cell Differentiation Negative Regulation Of Apoptotic Process Regulation Of Cell Population Proliferation Negative Regulation Of Programmed Cell Death Structural Constituent Of Chromatin Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Fibroblast Proliferation Enzyme Binding Tissue Morphogenesis Regulation Of Myofibroblast Contraction Intracellular Signal Transduction Positive Regulation Of Mitotic Cell Cycle Phase Transition DNA-templated Transcription Regulation Of Mitotic Cell Cycle Regulation Of Gliogenesis Signal Transduction By P53 Class Mediator	Regulation Of Translational Initiation Regulation Of Translation TOR Signaling Negative Regulation Of Protein Ubiquitination Translation Negative Regulation Of Translational Initiation Phosphatidylinositol-3,4,5-trisphosphate Binding Response To Heat Positive Regulation Of Translational Initiation Positive Regulation Of TOR Signaling Positive Regulation Of TORC1 Signaling Regulation Of TRNA Methylation Response To Peptide Hormone TORC1 Signaling Translational Initiation Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Proteolysis Carbohydrate Homeostasis Response To Rapamycin Positive Regulation Of Protein Localization To Endoplasmic Reticulum Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nitric-oxide Synthase Regulator Activity Positive Regulation Of RNA Biosynthetic Process Glucose Homeostasis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of SREBP Signaling Pathway Response To Insulin-like Growth Factor Stimulus Cytoplasmic Translation Response To Temperature Stimulus Negative Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of TORC2 Signaling TRNA Stabilization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Regulation Of Protein Localization To Cell Periphery Potassium Channel Activator Activity Regulation Of Protein Ubiquitination Mammalian Oogenesis Stage RNA (guanine-N7)-methylation Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of TORC1 Signaling Negative Regulation Of Fatty Acid Transport Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Cellular Response To Peptide Regulation Of Glucose Metabolic Process Response To Hormone Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of TOR Signaling
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