GET1 and SLC4A2

		GET1	SLC4A2
Description		guided entry of tail-anchored proteins factor 1	solute carrier family 4 member 2
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GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane GET Complex	Plasma Membrane Focal Adhesion Membrane Basolateral Plasma Membrane Apical Plasma Membrane
	Molecular Function	Protein Binding Protein-membrane Adaptor Activity	Solute:inorganic Anion Antiporter Activity Protein Binding Monoatomic Anion Transmembrane Transporter Activity Antiporter Activity Enzyme Binding Transmembrane Transporter Activity Chloride:bicarbonate Antiporter Activity
	Biological Process	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Sensory Perception Of Sound Protein Insertion Into ER Membrane Synapse Organization Protein Stabilization Establishment Of Localization In Cell Otic Vesicle Development Tail-anchored Membrane Protein Insertion Into ER Membrane Establishment Of Protein Localization To Membrane	Monoatomic Ion Transport Monoatomic Anion Transport Spermatogenesis Inorganic Anion Transport Bicarbonate Transport Osteoclast Differentiation Regulation Of Actin Cytoskeleton Organization Negative Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Regulation Of Bone Resorption Digestive Tract Development Regulation Of Intracellular PH Transmembrane Transport Positive Regulation Of Enamel Mineralization Amelogenesis Monoatomic Anion Transmembrane Transport Chloride Transmembrane Transport Negative Regulation Of CD8-positive, Alpha-beta T Cell Proliferation
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Bicarbonate transporters
Drugs
Diseases
GWAS			Eyebrow thickness ( 26926045) Heel bone mineral density ( 30598549) Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		34 interacting genes: ABHD5 APOA2 APOL2 AQP1 BOC CAMLG CCL4L2 CD302 CD53 CLCN7 COMT COX20 ERG28 GATD3 HMOX2 HTATIP2 ORMDL3 PDXK PLPP4 PTPN9 RASGRP3 RTP2 SCN3A SERP2 SLC35E3 SLC4A2 SLC7A1 SPTSSA STX2 TECR TFRC TM4SF19 TMEM42 TRAPPC10	4 interacting genes: ATXN1 CA2 EPB42 GET1
Entrez ID		7485	6522
HPRD ID		04224	02728
Ensembl ID		ENSG00000182093	ENSG00000164889
Uniprot IDs		O00258	P04920 Q59GF1
PDB IDs		6SO5 8CQZ 8CR1 8CR2	8GV8 8GV9 8GVA 8GVC 8GVE 8GVF 8GVH 8JNI 8JNJ 8ZLE
Enriched GO Terms of Interacting Partners?		Basolateral Plasma Membrane Membrane Serine Palmitoyltransferase Complex	Regulation Of Biological Quality Positive Regulation Of Dipeptide Transmembrane Transport Cyanamide Hydratase Activity GET Complex Arylesterase Activity Positive Regulation Of Cellular PH Reduction Regulation Of Chloride Transport POZ Domain Binding Ankyrin-1 Complex Protein-glutamine Gamma-glutamyltransferase Activity Poly(G) Binding Otic Vesicle Development Animal Organ Development Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Hemoglobin Metabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Nuclear Inclusion Body Regulation Of Monoatomic Anion Transport Carbonate Dehydratase Activity Carbon Dioxide Transport Positive Regulation Of Synaptic Transmission, GABAergic Tail-anchored Membrane Protein Insertion Into ER Membrane Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Angiotensin-activated Signaling Pathway Erythrocyte Maturation Poly(U) RNA Binding Positive Regulation Of Glial Cell Proliferation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway One-carbon Compound Transport Multicellular Organismal-level Iron Ion Homeostasis Myelin Sheath Cortical Cytoskeleton Protein Targeting To ER Protein Insertion Into ER Membrane Regulation Of Synaptic Transmission, GABAergic Developmental Process Insulin-like Growth Factor Receptor Signaling Pathway Protein-membrane Adaptor Activity Establishment Of Protein Localization To Endoplasmic Reticulum
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