DAGLA and TIMM10

		DAGLA	TIMM10
Description		diacylglycerol lipase alpha	translocase of inner mitochondrial membrane 10
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Membrane Early Endosome Membrane Dendrite Membrane Dendritic Spine Membrane Cell Projection Varicosity Synapse Postsynaptic Membrane Postsynaptic Density Membrane	Mitochondrion Mitochondrial Inner Membrane TIM23 Mitochondrial Import Inner Membrane Translocase Complex Mitochondrial Intermembrane Space Membrane Mitochondrial Intermembrane Space Chaperone Complex TIM22 Mitochondrial Import Inner Membrane Insertion Complex
	Molecular Function	Lipoprotein Lipase Activity Protein Binding Hydrolase Activity Metal Ion Binding Monoacylglycerol Lipase Activity	Protein Binding Zinc Ion Binding Membrane Insertase Activity Protein Homodimerization Activity Metal Ion Binding Protein-folding Chaperone Binding
	Biological Process	Lipid Metabolic Process Acylglycerol Metabolic Process Monoacylglycerol Biosynthetic Process Neuroblast Proliferation Lipid Catabolic Process Arachidonate Metabolic Process Neurogenesis Diacylglycerol Catabolic Process Retrograde Trans-synaptic Signaling By Endocannabinoid Regulation Of Neuroinflammatory Response Cannabinoid Biosynthetic Process	Protein Targeting To Mitochondrion Sensory Perception Of Sound Protein Transport Protein Insertion Into Mitochondrial Inner Membrane
Pathways		Arachidonate production from DAG	Mitochondrial protein import Mitochondrial protein import Mitochondrial protein degradation
Drugs
Diseases
GWAS		Bipolar disorder ( 28115744 31043756) Fasting plasma glucose ( 32902719) Immune reponse to smallpox (secreted IL-2) ( 22610502) Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Red blood cell fatty acid levels ( 25500335) Refractive error ( 32231278)	Worry too long after an embarrassing experience ( 29500382)
Interacting Genes		10 interacting genes: CMTM7 LHFPL5 MAL MALL MS4A13 STOM TMEM218 TRARG1 UPK1B VMA21	3 interacting genes: - TBC1D21 ZNF655
Entrez ID		747	26519
HPRD ID		07092	03768
Ensembl ID		ENSG00000134780	ENSG00000134809
Uniprot IDs		Q9Y4D2	P62072
PDB IDs			2BSK 7CGP
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Myelin Sheath Membrane Membrane Raft Establishment Of Protein Localization To Membrane Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Protein Insertion Into Membrane Myelination Apical Plasma Membrane Axon Ensheathment Membrane Raft Polarization Apical Plasma Membrane Urothelial Plaque B-1a B Cell Differentiation Protein Localization To Paranode Region Of Axon B-1 B Cell Differentiation Localization Within Membrane Membrane Raft Distribution Peptidase Activator Activity Involved In Apoptotic Process Sensory Perception Of Sound TIM22 Mitochondrial Import Inner Membrane Insertion Complex Sensory Perception Of Mechanical Stimulus Mitochondrial Intermembrane Space Chaperone Complex Vacuolar Proton-transporting V-type ATPase Complex Assembly Proton-transporting V-type ATPase Complex Assembly Glucose Import In Response To Insulin Stimulus	Aldehyde Metabolic Process Positive Regulation Of Deacetylase Activity Glycerone Kinase Activity Triokinase Activity FAD-AMP Lyase (cyclizing) Activity Retrograde Trans-synaptic Signaling By Endocannabinoid Monoacylglycerol Biosynthetic Process Cannabinoid Biosynthetic Process Diacylglycerol Catabolic Process Negative Regulation Of Photoreceptor Cell Differentiation Regulation Of Retinal Cell Programmed Cell Death Ciliary Neurotrophic Factor Receptor Binding Interleukin-6 Receptor Binding Ciliary Neurotrophic Factor-mediated Signaling Pathway Hydroxyacylglutathione Hydrolase Activity Methylglyoxal Metabolic Process Methylglyoxal Catabolic Process To Lactate Cellular Detoxification Of Methylglyoxal Methylglyoxal Catabolic Process To D-lactate Via S-lactoyl-glutathione CCR1 Chemokine Receptor Binding Release From Viral Latency Glycerol Catabolic Process Fructose Catabolic Process Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate Negative Regulation Of MDA-5 Signaling Pathway Sperm Mitochondrial Sheath Assembly Varicosity Muscle Organ Morphogenesis Lipoprotein Lipase Activity Positive Regulation Of Axon Regeneration Retinal Rod Cell Differentiation CAMP Response Element Binding Protein Binding Plasma Membrane To Endosome Transport Monoacylglycerol Lipase Activity Glyceraldehyde-3-phosphate Metabolic Process
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