VEGFB and SF1

		VEGFB	SF1
Description		vascular endothelial growth factor B	splicing factor 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Platelet Alpha Granule Lumen	Nucleus Nucleoplasm Spliceosomal Complex Ribosome U2AF Complex
	Molecular Function	Vascular Endothelial Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity Identical Protein Binding Vascular Endothelial Growth Factor Receptor 1 Binding Receptor Ligand Activity	Nucleic Acid Binding Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Response To Hypoxia Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Protein O-linked Glycosylation Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Vascular Wound Healing Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Vascular Permeability Negative Regulation Of Neuron Apoptotic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cardiac Muscle Contraction Positive Regulation Of Mast Cell Chemotaxis Coronary Vasculature Development Positive Regulation Of ERK1 And ERK2 Cascade	Spliceosomal Complex Assembly MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing MRNA Cis Splicing, Via Spliceosome Negative Regulation Of DNA-templated Transcription Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Primary Metabolic Process
Pathways		Platelet degranulation VEGF ligand-receptor interactions VEGF binds to VEGFR leading to receptor dimerization	mRNA Splicing - Major Pathway
Drugs		Aflibercept	Artenimol
Diseases		Gastric cancer
GWAS		A body shape index ( 34021172) Apolipoprotein A1 levels ( 32203549) Crohn's disease ( 28067908) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Fruit consumption ( 32066663) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Red blood cell count ( 32888494) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412)	Mean reticulocyte volume ( 32888494) Urate levels ( 21768215)
Interacting Genes		11 interacting genes: ADRB2 FLT1 FOSL1 KLHL12 NRP1 SF1 TFB1M TNXB UCP2 UCP3 VEGFA	91 interacting genes: ALG13 APBB1 APOBEC3C ATXN1 BAG4 BCAS2 BCL2 BUD31 CDC42 CEBPA CEP55 CPSF7 CTBP1 CTTN DCN DDX17 DMRTB1 DUX4L9 EWSR1 EXOSC1 EXOSC8 FAM168A FUS GAS7 HNRNPF HNRNPH1 HNRNPH2 HNRNPK HNRNPUL1 IDH3A IL7R ILF3 ITCH KHDRBS2 KPNA1 KRT31 KRTAP26-1 LINC00632 MIR106B MIR155 MIR19B2 MIR34A MIRLET7G MKRN3 NCK2 NEIL3 NFKB1 OGT OSTF1 PDAP1 PLSCR1 PRKG1 PRPF39 PRPF40A PRRC2B PSMA3 PUF60 PUS7 RBFOX2 RBM10 RBM17 RBM4 RBM7 RBMX RBPMS RPA2 RSPH1 SEC23A SF3B1 SF3B4 SFPQ SNRPA TAF15 TCERG1 TFIP11 TNPO2 TRIM23 TRIM69 TTN TXNL4B U2AF2 UBL5 USO1 VEGFB WBP4 WDR77 WDR83 WWP2 YTHDF1 YTHDF3 ZNF461
Entrez ID		7423	7536
HPRD ID		03237	03306
Ensembl ID		ENSG00000173511	ENSG00000168066
Uniprot IDs		P49765 Q7LAP4	A0A7P0T9U7 A0A9L9PXE4 B4DX42 H7C561 Q15637
PDB IDs		2C7W 2VWE 2XAC 6TKK	1K1G 1O0P 1OPI 2M09 2M0G 4FXW 4FXX 7VH9 7VPX 8PXX
Enriched GO Terms of Interacting Partners?		Adaptive Thermogenesis Vascular Endothelial Growth Factor Signaling Pathway VEGF-activated Neuropilin Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Sprouting Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Cold Neuropilin Signaling Pathway Oxidative Phosphorylation Uncoupler Activity Response To Superoxide Positive Regulation Of Axon Extension Involved In Axon Guidance Vascular Endothelial Growth Factor Receptor Activity Response To Oxygen Radical Coronary Artery Morphogenesis Coronary Vasculature Morphogenesis Endothelial Cell Chemotaxis Regulation Of MAPK Cascade Positive Regulation Of Cold-induced Thermogenesis Blood Vessel Morphogenesis Commissural Neuron Axon Guidance Motor Neuron Migration Chemotaxis Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Axon Extension Involved In Axon Guidance Locomotion Mitochondrial Transmembrane Transport Retinal Ganglion Cell Axon Guidance Regulation Of Cold-induced Thermogenesis Response To Temperature Stimulus Regulation Of Endothelial Cell Proliferation Proton Transmembrane Transporter Activity Cell Migration Involved In Sprouting Angiogenesis Heparin Binding Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Population Proliferation Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Angiogenesis Positive Regulation Of Vasculature Development Branching Involved In Blood Vessel Morphogenesis Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Receptor Complex Mitochondrial Transport Platelet-derived Growth Factor Receptor Signaling Pathway Blood Vessel Endothelial Cell Migration Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Cell Chemotaxis Positive Regulation Of Axon Extension Growth Factor Binding	RNA Splicing MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing MRNA Metabolic Process RNA Binding RNA Metabolic Process Nucleic Acid Binding Regulation Of RNA Splicing Nucleic Acid Metabolic Process Spliceosomal Complex Regulation Of MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleobase-containing Compound Metabolic Process Nucleoplasm Nucleus Macromolecule Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Alternative MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Catalytic Step 2 Spliceosome Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression MRNA Binding Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nuclear Speck Negative Regulation Of Macromolecule Biosynthetic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of MRNA Metabolic Process U2-type Prespliceosome Identical Protein Binding Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Ribonucleoprotein Complex Negative Regulation Of MRNA Splicing, Via Spliceosome MRNA 3'-UTR Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of RNA Splicing
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