KDM6A and RBM3

		KDM6A	RBM3
Description		lysine demethylase 6A	RNA binding motif protein 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Large Ribosomal Subunit Dendrite Cell Projection
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Oxidoreductase Activity Chromatin DNA Binding Histone Demethylase Activity Metal Ion Binding Dioxygenase Activity Histone H3K27me2/H3K27me3 Demethylase Activity	Nucleic Acid Binding RNA Binding Protein Binding Ribosomal Large Subunit Binding
	Biological Process	Chromatin Organization Chromatin Remodeling Heart Development Regulation Of Gene Expression	RNA Processing Regulation Of Translation Positive Regulation Of Translation Positive Regulation Of MRNA Splicing, Via Spliceosome
Pathways		HDMs demethylate histones Activation of anterior HOX genes in hindbrain development during early embryogenesis Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes Chromatin modifications during the maternal to zygotic transition (MZT) MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS
Interacting Genes		22 interacting genes: AKAP4 BMP15 CREBBP ELK1 GSC2 H3-4 H3C1 H3C14 HSD17B10 HUNK MAGED2 MEOX2 MTDH NKX2-5 RBM3 RSPH1 SMAD9 SRF TBX5 TLE1 TSPYL2 ZNF157	19 interacting genes: CEBPA CHTOP HNRNPA0 HNRNPLL HNRNPR IL7R KDM6A KHDRBS2 KHDRBS3 MYPOP PCBP1 PRR3 RBMX RBMY1A1 RBMY1F RBMY1J RBPMS2 SNRPA SRSF3
Entrez ID		7403	5935
HPRD ID		02131	02067
Ensembl ID		ENSG00000147050	ENSG00000102317
Uniprot IDs		A0A087X0R0 A0A6Q8PFK0 A0A804HJA2 B4E0L8 B7ZKN1 B7ZKN5 B7ZKN6 E1U0S6 F5H5V6 F5H6S1 F8W8R6 O15550 Q59HG3	P98179
PDB IDs		3AVR 3AVS 6FUK 6FUL	7EB1
Enriched GO Terms of Interacting Partners?		RNA Polymerase II-specific DNA-binding Transcription Factor Binding Chromatin Atrioventricular Node Cell Fate Commitment Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus His-Purkinje System Cell Differentiation Regulation Of RNA Metabolic Process Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Transcription Regulator Complex Nucleosome Assembly DNA-binding Transcription Factor Activity DNA Binding Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Chromatin Binding Regulation Of RNA Biosynthetic Process Nucleosome Organization Cardiocyte Differentiation Muscle Tissue Development Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Atrial Septum Development Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Cardiac Chamber Formation Protein-DNA Complex Assembly Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Atrial Cardiac Muscle Tissue Development Ventricular Cardiac Muscle Tissue Development Regulation Of Primary Metabolic Process Muscle Cell Fate Commitment Heart Trabecula Formation Positive Regulation Of Cardiocyte Differentiation RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cardiac Myofibril Assembly Structural Constituent Of Chromatin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Atrial Septum Morphogenesis Epithelium Development Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleoplasm Regulation Of Metabolic Process Cellular Component Assembly Muscle Cell Differentiation Positive Regulation Of Stem Cell Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process	Nucleic Acid Binding MRNA Binding MRNA Processing Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome RNA Binding Regulation Of MRNA Processing MRNA Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Metabolic Process RNA Processing Positive Regulation Of RNA Splicing Nucleic Acid Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Spliceosomal Complex RNA Splicing Nucleobase-containing Compound Metabolic Process Nucleoplasm Ribonucleoprotein Complex Nucleus Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of MRNA Metabolic Process Positive Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Identical Protein Binding Nucleolus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Protein Domain Specific Binding Response To Vitamin B2 C/EBP Complex Interleukin-7 Receptor Activity Sequence-specific Single Stranded DNA Binding Protein-RNA Sequence-specific Adaptor Activity Positive Regulation Of Helicase Activity MRNA Export From Nucleus CHOP-C/EBP Complex Supraspliceosomal Complex Positive Regulation Of Macromolecule Metabolic Process RNA Export From Nucleus
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