KDM6A and HSD17B10

		KDM6A	HSD17B10
Description		lysine demethylase 6A	hydroxysteroid 17-beta dehydrogenase 10
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex	Cytoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Mitochondrial Ribonuclease P Complex Mitochondrial Nucleoid TRNA Methyltransferase Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Oxidoreductase Activity Chromatin DNA Binding Histone Demethylase Activity Metal Ion Binding Dioxygenase Activity Histone H3K27me2/H3K27me3 Demethylase Activity	TRNA Binding RNA Binding (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Protein Binding Cholate 7-alpha-dehydrogenase (NAD+) Activity Oxidoreductase Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Testosterone Dehydrogenase (NAD+) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity
	Biological Process	Chromatin Organization Chromatin Remodeling Heart Development Regulation Of Gene Expression	L-isoleucine Catabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Bile Acid Biosynthetic Process Mitochondrion Organization TRNA Processing Steroid Metabolic Process C21-steroid Hormone Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process Protein Homotetramerization Brexanolone Metabolic Process Mitochondrial TRNA Methylation Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing
Pathways		HDMs demethylate histones Activation of anterior HOX genes in hindbrain development during early embryogenesis Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes Chromatin modifications during the maternal to zygotic transition (MZT) MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	tRNA processing in the mitochondrion tRNA modification in the mitochondrion Branched-chain amino acid catabolism rRNA processing in the mitochondrion Mitochondrial protein degradation
Drugs			NADH 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct Omega-3-carboxylic acids
Diseases			Non-syndromic X-linked mental retardation Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH) 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency; HSD10 deficiency
GWAS			Bipolar disorder ( 31043756) Body mass index ( 28892062)
Interacting Genes		22 interacting genes: AKAP4 BMP15 CREBBP ELK1 GSC2 H3-4 H3C1 H3C14 HSD17B10 HUNK MAGED2 MEOX2 MTDH NKX2-5 RBM3 RSPH1 SMAD9 SRF TBX5 TLE1 TSPYL2 ZNF157	31 interacting genes: ALDH3B1 ALDOA APP ATP5F1A CDC42 CHD3 CPS1 CS ETFDH FAF1 GLUD1 GLUL HADHA HADHB HMGCL HMGCS2 HTRA2 KDM6A MDH1 OGDH PDHB PDHX PTEN PYGL TOMM20 TOMM22 TOMM40 TRAF3IP2 TRAF5 TRAF6 UBE2D1
Entrez ID		7403	3028
HPRD ID		02131	02223
Ensembl ID		ENSG00000147050	ENSG00000072506
Uniprot IDs		A0A087X0R0 A0A6Q8PFK0 A0A804HJA2 B4E0L8 B7ZKN1 B7ZKN5 B7ZKN6 E1U0S6 F5H5V6 F5H6S1 F8W8R6 O15550 Q59HG3	A0A0S2Z410 Q99714
PDB IDs		3AVR 3AVS 6FUK 6FUL	1SO8 1U7T 2O23 7ONU 8CBK 8CBL 8CBM 8CBO 8RR1 8RR3 8RR4 9EY0 9EY1 9EY2 9GCH
Enriched GO Terms of Interacting Partners?		RNA Polymerase II-specific DNA-binding Transcription Factor Binding Chromatin Atrioventricular Node Cell Fate Commitment Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus His-Purkinje System Cell Differentiation Regulation Of RNA Metabolic Process Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Transcription Regulator Complex Nucleosome Assembly DNA-binding Transcription Factor Activity DNA Binding Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Chromatin Binding Regulation Of RNA Biosynthetic Process Nucleosome Organization Cardiocyte Differentiation Muscle Tissue Development Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Atrial Septum Development Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Cardiac Chamber Formation Protein-DNA Complex Assembly Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Atrial Cardiac Muscle Tissue Development Ventricular Cardiac Muscle Tissue Development Regulation Of Primary Metabolic Process Muscle Cell Fate Commitment Heart Trabecula Formation Positive Regulation Of Cardiocyte Differentiation RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cardiac Myofibril Assembly Structural Constituent Of Chromatin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Atrial Septum Morphogenesis Epithelium Development Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleoplasm Regulation Of Metabolic Process Cellular Component Assembly Muscle Cell Differentiation Positive Regulation Of Stem Cell Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process	Mitochondrion Organic Acid Metabolic Process Carboxylic Acid Metabolic Process Small Molecule Metabolic Process Mitochondrial Matrix TOM Complex Tricarboxylic Acid Cycle Mitochondrial Outer Membrane Translocase Complex CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway CD40 Receptor Complex Protein Insertion Into Mitochondrial Outer Membrane Catabolic Process Carboxylic Acid Catabolic Process Organophosphate Metabolic Process Oxidoreductase Activity Glutamine Metabolic Process Pyruvate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Mitochondrial Fatty Acid Beta-oxidation Multienzyme Complex Mitochondrial Inner Membrane Protein Import Into Mitochondrial Matrix Lipid Metabolic Process Monocarboxylic Acid Metabolic Process Protein Transmembrane Transporter Activity Generation Of Precursor Metabolites And Energy Purine-containing Compound Metabolic Process Catalytic Activity Dicarboxylic Acid Metabolic Process Protein Targeting To Mitochondrion Acyl-CoA Metabolic Process Acetyl-CoA Metabolic Process Protein Insertion Into Mitochondrial Membrane Establishment Of Protein Localization To Mitochondrial Membrane Ketone Body Biosynthetic Process Mitochondrion Targeting Sequence Binding Organophosphate Biosynthetic Process Cytoplasmic Side Of Plasma Membrane Nucleoside Phosphate Metabolic Process Acetyl-CoA C-acetyltransferase Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Interleukin-17A-mediated Signaling Pathway Protein Localization To Mitochondrion Neuron Projection Organization Enoyl-CoA Hydratase Activity Pyruvate Decarboxylation To Acetyl-CoA Sulfur Compound Metabolic Process Midgut Development Mitochondrial Nucleoid L-glutamate Catabolic Process
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