UCHL3 and PKD2

		UCHL3	PKD2
Description		ubiquitin C-terminal hydrolase L3	polycystin 2, transient receptor potential cation channel
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Golgi Apparatus Cytosol	Polycystin Complex Extracellular Region Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Cell-cell Junction Cilium Basal Plasma Membrane Membrane Basolateral Plasma Membrane Lamellipodium Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Motile Cilium Vesicle Monoatomic Ion Channel Complex Cation Channel Complex Ciliary Basal Body Cell Projection Basal Cortex Ciliary Membrane Extracellular Exosome Mitotic Spindle Non-motile Cilium Lumenal Side Of Endoplasmic Reticulum Membrane Cytoplasmic Side Of Endoplasmic Reticulum Membrane Migrasome
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeNEDDylase Activity Ubiquitin Binding Deubiquitinase Activity	Signaling Receptor Binding Voltage-gated Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Voltage-gated Sodium Channel Activity Voltage-gated Potassium Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Potassium Channel Activity Sodium Channel Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Channel Activity Outward Rectifier Potassium Channel Activity Voltage-gated Monoatomic Cation Channel Activity Identical Protein Binding Protein Homodimerization Activity Actinin Binding HLH Domain Binding Transmembrane Transporter Binding Metal Ion Binding Calcium-induced Calcium Release Activity ATPase Binding Phosphoprotein Binding Muscle Alpha-actinin Binding Transcription Regulator Inhibitor Activity
	Biological Process	Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Deubiquitination Protein Catabolic Process Post-translational Protein Modification	Branching Involved In Ureteric Bud Morphogenesis Kidney Development Liver Development Embryonic Placenta Development Heart Looping Detection Of Nodal Flow Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Determination Of Left/right Symmetry Heart Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Wnt Signaling Pathway Calcium-mediated Signaling Spinal Cord Development Neural Tube Development Monoatomic Ion Transmembrane Transport Cellular Response To Reactive Oxygen Species Metanephric Part Of Ureteric Bud Development Sodium Ion Transmembrane Transport Aorta Development Regulation Of Cell Population Proliferation Chordate Embryonic Development Cilium Organization Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Detection Of Mechanical Stimulus Release Of Sequestered Calcium Ion Into Cytosol Protein Tetramerization Protein Homotetramerization Protein Heterotetramerization Centrosome Duplication Establishment Of Localization In Cell Regulation Of Cell Cycle Placenta Blood Vessel Development Renal Tubule Morphogenesis Renal Artery Morphogenesis Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To CAMP Cellular Response To Hydrostatic Pressure Cellular Response To Osmotic Stress Cellular Response To Fluid Shear Stress Potassium Ion Transmembrane Transport Determination Of Liver Left/right Asymmetry Metanephric Mesenchyme Development Mesonephric Tubule Development Mesonephric Duct Development Metanephric Smooth Muscle Tissue Development Metanephric Cortex Development Metanephric Ascending Thin Limb Development Metanephric Cortical Collecting Duct Development Metanephric Distal Tubule Development Metanephric S-shaped Body Morphogenesis Regulation Of Calcium Ion Import Inorganic Cation Transmembrane Transport Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		UCH proteinases Synthesis of active ubiquitin: roles of E1 and E2 enzymes Neddylation	VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs
Diseases			Polycystic kidney disease
GWAS		Diabetic retinopathy ( 23562823) Metabolite levels ( 23823483)	Coffee consumption (cups per day) ( 25288136) Dental caries ( 23064961) Gout ( 30899057) Hyperuricemia ( 28776340) Serum alkaline phosphatase levels ( 33547301) Serum uric acid levels in response to allopurinol in gout ( 25676789) Uric acid levels ( 29558500)
Interacting Genes		24 interacting genes: ATM ATXN7L3 CCNB1 CDH1 CEBPA FOXM1 LONRF1 NEDD8 NSG2 PJA1 PKD2 PLA2G2A POGK RAD51 TRIM27 TRIM54 TRIM55 TRIM63 UBE2S USP15 USP21 USP28 XRCC5 YAP1	27 interacting genes: ACTN2 ADH1A ADH1C CD2AP CYSRT1 DIAPH1 HAX1 HSF2BP KIF11 KRT40 KRTAP10-3 KRTAP10-8 KRTAP6-2 LMNA MAGEA8 MDFI MTAP PACS1 PACS2 PKD1 PLSCR1 PPP3CA PTPRG TNNI3 TPM1 TRPC1 UCHL3
Entrez ID		7347	5311
HPRD ID		04367	01437
Ensembl ID		ENSG00000118939	ENSG00000118762
Uniprot IDs		A0A140VJZ4 P15374	Q13563 Q9UEU6
PDB IDs		1UCH 1XD3 6ISU 6QML 7YV4	2KLD 2KLE 2KQ6 2Y4Q 3HRN 3HRO 5K47 5MKE 5MKF 5T4D 6A70 6D1W 6T9N 6T9O 6WB8 8HK7 8K3S 9DLI 9DWQ
Enriched GO Terms of Interacting Partners?		Cellular Response To Gamma Radiation Post-translational Protein Modification Response To Gamma Radiation Response To Ionizing Radiation Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Radiation Protein K63-linked Ubiquitination Cellular Response To Ionizing Radiation Protein Ubiquitination Response To Stress Cellular Response To Camptothecin Regulation Of Primary Metabolic Process Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Cellular Response To Metal Ion Ubiquitin Protein Ligase Activity Cellular Response To Oxygen-containing Compound Cellular Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Lithium Ion Nucleoplasm Interleukin-6-mediated Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Lithium Ion Cysteine-type Deubiquitinase Activity Regulation Of DNA Repair Response To Radiation Regulation Of Cell Cycle Phase Transition Regulation Of Metabolic Process Protein Deubiquitination Telomere Maintenance Signal Transduction By P53 Class Mediator Response To Toxic Substance Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein-containing Complex Organization Regulation Of Cell Cycle Regulation Of Macromolecule Metabolic Process Regulation Of DNA Metabolic Process Gland Development Hematopoietic Stem Cell Proliferation Embryonic Placenta Development Deubiquitinase Activity Protein Polyubiquitination Protein Modification By Small Protein Removal DNA Damage Response	Transmembrane Transporter Binding Intermediate Filament Actin Filament Sarcomere Alcohol Dehydrogenase (NAD+) Activity Actin Filament Binding Striated Muscle Cell Development Regulation Of Cytoskeleton Organization Actin Binding Cytosol All-trans-retinol Dehydrogenase (NAD+) Activity Cation Channel Complex Actin-myosin Filament Sliding Muscle Filament Sliding Protein Domain Specific Binding Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Keratin Filament Muscle Cell Development Structural Constituent Of Cytoskeleton Regulation Of Muscle System Process Positive Regulation Of Cation Transmembrane Transport Regulation Of Monoatomic Cation Transmembrane Transport Retinoic Acid Metabolic Process Protein Heterooligomerization Actin Cytoskeleton Positive Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Biological Quality Actin Filament Uncapping Identical Protein Binding Butanol Dehydrogenase (NAD+) Activity Ethanol Dehydrogenase (NAD+) Activity Actin Filament Polymerization Regulation Of Calcium Ion Transmembrane Transport Regulation Of System Process S-methyl-5-thioadenosine Phosphorylase Activity Metanephric Distal Tubule Morphogenesis Monoatomic Cation Channel Activity Regulation Of ATP-dependent Activity Negative Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Cell Proliferation Involved In Kidney Morphogenesis Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Positive Regulation Of Heart Rate By Epinephrine Actin-mediated Cell Contraction
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