TUBA4A and CAPN2

		TUBA4A	CAPN2
Description		tubulin alpha 4a	calpain 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Cytoskeleton Microtubule Cilium Microtubule Cytoskeleton Extracellular Exosome	Chromatin Nucleus Cytoplasm Lysosome Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Membrane Dendrite Cortical Actin Cytoskeleton Pseudopodium Cell Projection Neuronal Cell Body Membrane Raft Extracellular Exosome Perinuclear Endoplasmic Reticulum Presynapse Postsynapse Calpain Complex
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Hydrolase Activity Enzyme Binding Protein Kinase Binding Metal Ion Binding	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Enzyme Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process	Response To Hypoxia Blastocyst Development Proteolysis Myoblast Fusion Female Pregnancy Response To Mechanical Stimulus Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Protein Autoprocessing Protein Catabolic Process Regulation Of Interleukin-6 Production Cellular Response To Interferon-beta Response To Hydrogen Peroxide Behavioral Response To Pain Synaptic Vesicle Endocytosis Regulation Of Cytoskeleton Organization Proteolysis Involved In Protein Catabolic Process Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Protein Catabolic Process At Postsynapse Positive Regulation Of Myoblast Fusion Positive Regulation Of Phosphatidylcholine Biosynthetic Process
Pathways		Platelet degranulation Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Anchoring of the basal body to the plasma membrane Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling	Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs		Vincristine Podofilox Epothilone D Patupilone CYT997 Cabazitaxel Phenethyl Isothiocyanate
Diseases
GWAS		Platelet distribution width ( 27863252 32888494) Severe autoimmune type 2 diabetes ( 34737425)	Blood protein levels ( 30072576) Carotenoid levels (alpha-carotene) ( 28002826) Febrile seizures (MMR vaccine-related) ( 25344690) Gut microbiota relative abundance (Eubacterium belonging to family Erysipelotrichaceae) ( 33208821) Waist circumference ( 31170924)
Interacting Genes		67 interacting genes: ALPP APC ARHGAP1 ATP5MC3 B4GALT1 BCAR1 BRCA1 C4orf17 CALB2 CAPN2 CDK5R2 CXCR1 DPYSL2 EGFR ENO2 EPB41 ETV6 FYN GNAI2 GPHN GRM7 HDAC6 HPCA HSPH1 IL1RL1 LGALS2 LTA MAGED1 MAP1A MAP1LC3A MAPT MARK4 MYC NCALD NUPR1 OGT PFDN4 PLK1 PRKN RAB8B RAC1 RACGAP1 RBM23 RTN4 S100A8 SIAH1 SIMC1 SIRT2 SKP1 SLC11A1 STARD13 STK16 SUMO2 SYK TAOK2 TBCB TBCE TCP1 TCP11L2 TM4SF1 UBC UCHL5 VAV1 VDAC1 WNT6 YWHAG ZAP70	24 interacting genes: ATG5 ATXN3 BCL2 BID CAPNS1 CAPNS2 CASP9 CDK5R1 DUX4 F2RL1 GAS2 GRK2 KCTD7 KNG1 MAPK1 MTDH NFKBIA NMT1 PBXIP1 PTPN1 PTPRN TNS1 TUBA4A ZFYVE21
Entrez ID		7277	824
HPRD ID		01851	00254
Ensembl ID		ENSG00000127824	ENSG00000162909
Uniprot IDs		P68366	B4DN77 P17655 Q59EF6
PDB IDs			1KFU 1KFX 2NQA
Enriched GO Terms of Interacting Partners?		Alpha-tubulin Binding Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Microtubule Cytosol Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Apoptotic Process Ubiquitin Protein Ligase Binding Regulation Of Cellular Component Organization Regulation Of Protein Localization Regulation Of Apoptotic Process Positive Regulation Of Protein Localization Plasma Membrane Tubulin Binding Regulation Of Protein Catabolic Process Dendrite Positive Regulation Of Intracellular Signal Transduction Cell Migration Regulation Of Cell Communication Regulation Of Signaling Regulation Of Organelle Organization Cytoskeleton Regulation Of Multicellular Organismal Process Microtubule Binding Tau Protein Binding Regulation Of Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytoplasm Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Signal Transduction Cell Motility Negative Regulation Of Catabolic Process Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Plasma Membrane Bounded Cell Projection Negative Regulation Of Protein Metabolic Process Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission Leukocyte Migration Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Cellular Response To L-glutamate Inclusion Body Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Tubulin Complex Assembly	Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Cytosol Epithelial Cell Apoptotic Process Response To Nutrient Levels Positive Regulation Of Programmed Cell Death Cellular Response To Nutrient Levels Calpain Complex Lipopolysaccharide-mediated Signaling Pathway Regulation Of Signal Transduction B Cell Receptor Signaling Pathway Vasodilation Positive Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Calcium-dependent Cysteine-type Endopeptidase Activity Cellular Response To Starvation Regulation Of Autophagy Apoptotic Process Programmed Cell Death Cell Death Regulation Of Cell Population Proliferation Response To Starvation Pseudopodium Viral Genome Replication Regulation Of Biological Quality G Protein-coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Peptidyl-threonine Phosphorylation Neuron Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Release Of Cytochrome C From Mitochondria Protease Binding Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Organelle Organization Regulation Of Cellular Localization Cellular Response To Topologically Incorrect Protein Regulation Of Establishment Of Protein Localization Protein Phosphatase 2A Binding Regulation Of Cellular Response To Stress Ubiquitin Protein Ligase Binding Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Iron Ion NF-kappaB Binding Regulation Of Transport Cellular Response To Stress Regulation Of Intracellular Signal Transduction Stem Cell Development
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