TUBA4A and DPYSL2

		TUBA4A	DPYSL2
Description		tubulin alpha 4a	dihydropyrimidinase like 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Cytoskeleton Microtubule Cilium Microtubule Cytoskeleton Extracellular Exosome	Cytoplasm Cytosol Cytoskeleton Microtubule Plasma Membrane Cilium Microtubule Cytoskeleton Membrane Extracellular Exosome Mitotic Spindle Plasma Membrane Bounded Cell Projection
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Hydrolase Activity Enzyme Binding Protein Kinase Binding Metal Ion Binding	Dihydropyrimidinase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Identical Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process	Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Catabolic Process Endocytosis Cytoskeleton Organization Signal Transduction Nervous System Development Cell Differentiation
Pathways		Platelet degranulation Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Anchoring of the basal body to the plasma membrane Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling	CRMPs in Sema3A signaling Recycling pathway of L1
Drugs		Vincristine Podofilox Epothilone D Patupilone CYT997 Cabazitaxel Phenethyl Isothiocyanate	Artenimol
Diseases
GWAS		Platelet distribution width ( 27863252 32888494) Severe autoimmune type 2 diabetes ( 34737425)	Barrett's esophagus or Esophageal adenocarcinoma ( 32918910) Barrett's esophagus or esophageal adenocarcinoma x sex interaction (1df test) ( 32918910) Barrett's esophagus or esophageal adenocarcinoma x sex interaction (2df test) ( 32918910) Bitter alcoholic beverage consumption ( 31046077) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
Interacting Genes		67 interacting genes: ALPP APC ARHGAP1 ATP5MC3 B4GALT1 BCAR1 BRCA1 C4orf17 CALB2 CAPN2 CDK5R2 CXCR1 DPYSL2 EGFR ENO2 EPB41 ETV6 FYN GNAI2 GPHN GRM7 HDAC6 HPCA HSPH1 IL1RL1 LGALS2 LTA MAGED1 MAP1A MAP1LC3A MAPT MARK4 MYC NCALD NUPR1 OGT PFDN4 PLK1 PRKN RAB8B RAC1 RACGAP1 RBM23 RTN4 S100A8 SIAH1 SIMC1 SIRT2 SKP1 SLC11A1 STARD13 STK16 SUMO2 SYK TAOK2 TBCB TBCE TCP1 TCP11L2 TM4SF1 UBC UCHL5 VAV1 VDAC1 WNT6 YWHAG ZAP70	20 interacting genes: AP2A1 CDC42 CRMP1 DISC1 DPYSL5 DSCAM DSCR9 EXOSC7 GORASP2 GSK3B LEF1 LUC7L NUMB PCM1 PLD2 ROCK1 TNIK TUBA4A TUBB UBE2I
Entrez ID		7277	1808
HPRD ID		01851	03914
Ensembl ID		ENSG00000127824	ENSG00000092964
Uniprot IDs		P68366	A0A1C7CYX9 Q16555 Q59GB4
PDB IDs			2GSE 2VM8 5LXX 5MKV 5MLE 5X1A 5X1C 5X1D 5YZ5 5YZA 5YZB 6JV9 6JVB 7X68 8DNM
Enriched GO Terms of Interacting Partners?		Alpha-tubulin Binding Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Microtubule Cytosol Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Apoptotic Process Ubiquitin Protein Ligase Binding Regulation Of Cellular Component Organization Regulation Of Protein Localization Regulation Of Apoptotic Process Positive Regulation Of Protein Localization Plasma Membrane Tubulin Binding Regulation Of Protein Catabolic Process Dendrite Positive Regulation Of Intracellular Signal Transduction Cell Migration Regulation Of Cell Communication Regulation Of Signaling Regulation Of Organelle Organization Cytoskeleton Regulation Of Multicellular Organismal Process Microtubule Binding Tau Protein Binding Regulation Of Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytoplasm Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Signal Transduction Cell Motility Negative Regulation Of Catabolic Process Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Plasma Membrane Bounded Cell Projection Negative Regulation Of Protein Metabolic Process Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission Leukocyte Migration Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Cellular Response To L-glutamate Inclusion Body Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Tubulin Complex Assembly	Glutamatergic Synapse Nervous System Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Neuron Projection Development Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell Projection Organization Positive Regulation Of Cell-matrix Adhesion System Development Cell Projection Organization Positive Regulation Of Cell Projection Organization Regulation Of Cell Development Regulation Of Neurogenesis Regulation Of Cell-substrate Adhesion Presynapse Cytoskeleton Organization Regulation Of Nervous System Development Wnt Signaling Pathway Neuron Projection Morphogenesis Regulation Of Cell-matrix Adhesion Cell Projection Morphogenesis Dihydropyrimidinase Activity Regulation Of Synapse Organization Regulation Of Cellular Component Organization Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Plasma Membrane Bounded Cell Projection Organization Pyrimidine Nucleobase Catabolic Process Positive Regulation Of Locomotion Regulation Of Dendrite Morphogenesis Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of Muscle Organ Development Negative Regulation Of Muscle Tissue Development Regulation Of Axon Extension Epithelial To Mesenchymal Transition Regulation Of Locomotion Apical Part Of Cell Cytoskeleton Cellular Component Assembly Regulation Of Developmental Process Dendrite Positive Regulation Of Cellular Component Organization Neuron Projection Development Regulation Of Dendrite Development Regulation Of Cell Differentiation Canonical Wnt Signaling Pathway Organelle Organization Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Beta-catenin Binding Pyrimidine Nucleobase Metabolic Process
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