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TRH and CD80
TRH
CD80
Description
thyrotropin releasing hormone
CD80 molecule
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Secretory Granule
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Protein Complex Involved In Cell Adhesion
Molecular Function
Hormone Activity
Protein Binding
Thyrotropin-releasing Hormone Activity
Virus Receptor Activity
Protein Binding
Coreceptor Activity
Receptor Ligand Activity
Biological Process
Histamine Metabolic Process
Signal Transduction
Cell-cell Signaling
Adult Walking Behavior
Hormone-mediated Signaling Pathway
Negative Regulation Of Glutamate Secretion
Positive Regulation Of Gamma-aminobutyric Acid Secretion
Positive Regulation Of Insulin Secretion
Eating Behavior
Immune System Process
Regulation Of Immune System Process
Negative Regulation Of T Cell Mediated Immunity
Immune Response
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
T Cell Costimulation
Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production
Positive Regulation Of Interleukin-2 Production
Intracellular Signal Transduction
Positive Regulation Of T Cell Proliferation
T Cell Activation
Negative Regulation Of T Cell Proliferation
Positive Regulation Of T-helper 1 Cell Differentiation
Positive Regulation Of DNA-templated Transcription
Symbiont Entry Into Host Cell
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Cellular Response To Lipopolysaccharide
Pathways
Peptide ligand-binding receptors
G alpha (q) signalling events
PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
Co-stimulation by CD28
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
Co-inhibition by CTLA4
Interleukin-10 signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Abatacept
Galiximab
Belatacept
Diseases
GWAS
Alzheimer's disease (
30636644
)
Hip index (
34021172
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
26426971
34021172
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Asthma (
32296059
)
Autoimmune thyroid disease (
32581359
)
Carotid plaque burden (
28282560
)
Celiac disease (
20190752
)
Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) (
23603761
)
Lobular breast cancer (menopausal hormone therapy interaction) (
24080446
)
Primary biliary cholangitis (
21399635
28425483
28062665
26394269
23000144
)
Primary biliary cirrhosis (
22961000
)
Systemic lupus erythematosus (
25862617
23273568
)
Systemic sclerosis (
31672989
)
Vitiligo (
27723757
22561518
)
Interacting Genes
8 interacting genes:
ARRB2
CD80
CD86
CPE
IQCB1
KCNIP4
LCN2
TRHR
9 interacting genes:
CD274
CD28
CD86
CTLA4
IQCB1
MRPL3
NGFR
TRH
UPK1B
Entrez ID
7200
941
HPRD ID
08944
00202
Ensembl ID
ENSG00000170893
ENSG00000121594
Uniprot IDs
P20396
A0N0P2
P33681
PDB IDs
1DR9
1I8L
7TPS
8FXW
8FXZ
8HXA
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation
T Cell Costimulation
Cellular Response To Molecule Of Bacterial Origin
Cellular Response To Lipopolysaccharide
Positive Regulation Of T-helper Cell Differentiation
Positive Regulation Of Interleukin-2 Production
Regulation Of T-helper Cell Differentiation
Response To Molecule Of Bacterial Origin
Response To Lipopolysaccharide
Regulation Of Interleukin-2 Production
Coreceptor Activity
Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Positive Regulation Of Alpha-beta T Cell Differentiation
Positive Regulation Of Hippocampal Neuron Apoptotic Process
Thyrotropin-releasing Hormone Receptor Activity
Angiotensin Receptor Binding
Cell Surface Receptor Signaling Pathway
Negative Regulation Of T Cell Proliferation
Negative Regulation Of Leukocyte Proliferation
Regulation Of CD4-positive, Alpha-beta T Cell Activation
Negative Regulation Of Lymphocyte Proliferation
Negative Regulation Of Mononuclear Cell Proliferation
Virus Receptor Activity
Positive Regulation Of Alpha-beta T Cell Activation
Positive Regulation Of Iron Ion Import Across Plasma Membrane
Enterobactin Binding
Positive Regulation Of Endothelial Tube Morphogenesis
Iron Ion Sequestering Activity
BBSome Binding
Cellular Response To Lipid
Positive Regulation Of T Cell Proliferation
Positive Regulation Of Synaptic Transmission, Dopaminergic
Positive Regulation Of Gene Expression
Positive Regulation Of T Cell Differentiation
Regulation Of Alpha-beta T Cell Activation
Symbiont Entry Into Host Cell
Positive Regulation Of Lymphotoxin A Production
Protein Localization To Secretory Granule
Siderophore Transport
Negative Regulation Of Immune System Process
Receptor Ligand Activity
Positive Regulation Of Lymphocyte Differentiation
Negative Regulation Of T Cell Activation
Cytoplasmic Vesicle Lumen
Negative Regulation Of Hippocampal Neuron Apoptotic Process
Response To Kainic Acid
Maintenance Of Animal Organ Identity
Positive Regulation Of Developmental Process
Beta-arrestin-dependent Dopamine Receptor Signaling Pathway
T Cell Costimulation
Regulation Of T Cell Proliferation
Protein Complex Involved In Cell Adhesion
Coreceptor Activity
Regulation Of Mononuclear Cell Proliferation
Negative Regulation Of T Cell Proliferation
Regulation Of Leukocyte Proliferation
Regulation Of CD4-positive, Alpha-beta T Cell Activation
Negative Regulation Of Lymphocyte Proliferation
Negative Regulation Of Mononuclear Cell Proliferation
Negative Regulation Of Leukocyte Proliferation
Positive Regulation Of T Cell Proliferation
External Side Of Plasma Membrane
Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of Alpha-beta T Cell Activation
Regulation Of T Cell Activation
Negative Regulation Of T Cell Activation
Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Positive Regulation Of Lymphocyte Proliferation
Positive Regulation Of Mononuclear Cell Proliferation
Negative Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Interleukin-4 Production
Regulation Of Cell-cell Adhesion
Positive Regulation Of Leukocyte Proliferation
Negative Regulation Of Lymphocyte Activation
Regulation Of Lymphocyte Activation
Regulation Of T Cell Differentiation
Regulation Of Interleukin-4 Production
Negative Regulation Of Leukocyte Activation
Negative Regulation Of Cell-cell Adhesion
Regulation Of Lymphocyte Differentiation
Regulation Of Regulatory T Cell Differentiation
Positive Regulation Of Interleukin-2 Production
Negative Regulation Of Cell Activation
Positive Regulation Of Interleukin-10 Production
Regulation Of Cell Activation
Positive Regulation Of Immune Response
Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation
Positive Regulation Of T Cell Activation
Positive Regulation Of Leukocyte Cell-cell Adhesion
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Immunoglobulin Production
Adaptive Immune Response
Negative Regulation Of Cell Adhesion
Regulation Of Cell Adhesion
Regulation Of Interleukin-2 Production
Regulation Of Interleukin-10 Production
Thyrotropin-releasing Hormone Activity
Regulation Of Activated CD4-positive, Alpha-beta T Cell Apoptotic Process
Positive Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process
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