TAF1 and NONO

		TAF1	NONO
Description		TATA-box binding protein associated factor 1	non-POU domain containing octamer binding
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Transcription Factor TFIID Complex Nucleolus MLL1 Complex	Fibrillar Center Nucleus Nucleoplasm Chromosome Nucleolus Membrane Nuclear Matrix Nuclear Speck Paraspeckles RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Nucleotide Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II General Transcription Initiation Factor Binding RNA Polymerase I General Transcription Initiation Factor Activity P53 Binding DNA Binding Histone Acetyltransferase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II General Transcription Initiation Factor Activity Kinase Activity Transferase Activity Acyltransferase Activity Nuclear Receptor Binding TBP-class Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Histone H3K27me3 Reader Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin Conjugating Enzyme Activity Protein-lysine-acetyltransferase Activity Protein Serine Kinase Activity Histone H4K16ac Reader Activity Transcription Regulator Inhibitor Activity Histone Reader Activity Acetyl-CoA Binding	Nucleic Acid Binding DNA Binding Chromatin Binding RNA Binding Protein Binding Identical Protein Binding LncRNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Chromatin Organization Chromatin Remodeling DNA-templated Transcription Initiation Transcription Initiation At RNA Polymerase I Promoter Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Negative Regulation Of Gene Expression Midbrain Development Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To UV MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Protein Stabilization RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Cellular Response To ATP Positive Regulation Of Androgen Receptor Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Protein Autoubiquitination Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Activation Of Innate Immune Response Immune System Process DNA Repair DNA Recombination Regulation Of DNA-templated Transcription MRNA Processing DNA Damage Response Circadian Rhythm RNA Splicing Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Innate Immune Response Negative Regulation Of DNA-templated Transcription Rhythmic Process Cellular Response To Hypoxia Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Angiotensin
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance
Drugs
Diseases
GWAS
Interacting Genes		72 interacting genes: APC APP AR ASF1A ASF1B BRMS1 BRWD1 BTG3 CCNA2 CCND1 CDC42BPA CFAP298 CLIP4 DNAJB5 DOCK9 DYSF EDF1 EWSR1 FOS FOXO4 GATD3 GFI1B GTF2A1 GTF2E1 GTF2F1 H1-1 H3-4 HMGB1 HSF1 HUNK ITGB5 JUN KIF4A LCOR LHX3 MAX MDM2 MED12 MSX1 MYOM2 NDUFS6 NONO PAX3 PDZD11 PRKD3 RANBP2 RB1 RBL1 RBL2 RELA SGCA SPTAN1 SUB1 SUMO2 TAF10 TAF11 TAF12 TAF15 TAF2 TAF4 TAF4B TAF5 TAF6 TAF7 TAF8 TAF9 TBP TP53 TTC3 UBE2I UBTF ZMYM3	126 interacting genes: APBB1 AR BHLHE41 C11orf68 CA2 CD44 CDK1 CEBPA DANCR DDX6 DELEC1 ERCC6 ERG ESR1 EWSR1 FXR2 H3-4 IL7R IRAK3 LINC00624 LMO4 MAD1L1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MYC MYCN OGT ORC5 OTUD5 PDE4B PIN1 PLEKHF2 POLR1H POLR2A PPP1CA PPP1CB PPP1CC PRKAA2 PRPF40A PSPC1 PTBP1 RNF8 SAMHD1 SFPQ SMARCB1 SMARCC1 SMARCD1 SPI1 SUMO2 SYNPO TAF1 TAFAZZIN TCERG1 UBE2I USP11 WBP4
Entrez ID		6872	4841
HPRD ID		02436	02098
Ensembl ID		ENSG00000147133	ENSG00000147140
Uniprot IDs		A0A804HIC2 P21675	A0A0S2Z4Z9 Q15233
PDB IDs		1EQF 3AAD 3UV4 3UV5 4RGW 4YYM 4YYN 5FUR 5I1Q 5I29 5MG2 6BQD 6FIC 6MZD 6MZL 6MZM 6P38 6P39 6P3A 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7EGD 7EGE 7EGH 7EGI 7EGJ 7ENA 7ENC 7JJG 7JJH 7JSP 7JTC 7K03 7K0D 7K0U 7K1P 7K27 7K3O 7K42 7K6F 7L6X 7LB0 7LB1 7LB2 7LB3 7N42 7P4S 7T2I 7T36 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS	3SDE 5IFM 6WMZ 7LRQ 7LRU 7PU5
Enriched GO Terms of Interacting Partners?		Transcription Factor TFIID Complex Regulation Of DNA-templated Transcription Initiation RNA Polymerase II General Transcription Initiation Factor Activity Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Transcription Initiation By RNA Polymerase II DNA-templated Transcription Initiation Transcription Initiation At RNA Polymerase II Promoter Nucleoplasm Transcription Preinitiation Complex Assembly DNA-templated Transcription RNA Polymerase II Preinitiation Complex Assembly Protein-DNA Complex Assembly MRNA Transcription Transcription By RNA Polymerase II MRNA Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process Nucleus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Factor TFTC Complex DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Macromolecule Biosynthetic Process Protein-containing Complex Assembly Regulation Of Gene Expression RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Metabolic Process Protein-containing Complex Organization Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Promoter-specific Chromatin Binding Protein Heterodimerization Activity Regulation Of Metabolic Process Nucleic Acid Metabolic Process Cellular Component Assembly	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Extracellular Vesicle Regulation Of Macromolecule Metabolic Process Negative Regulation Of Translation Regulation Of Metabolic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Translation Negative Regulation Of Developmental Process Negative Regulation Of Cell Migration Negative Regulation Of Locomotion Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Signal Transduction Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Protein Metabolic Process Regulation Of Angiogenesis Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Vasculature Development Regulation Of MRNA Stability Regulation Of RNA Stability Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Developmental Process Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Blood Vessel Endothelial Cell Migration
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