SLC9A1 and MTOR

		SLC9A1	MTOR
Description		solute carrier family 9 member A1	mechanistic target of rapamycin kinase
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Plasma Membrane Focal Adhesion Cell Surface Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lamellipodium T-tubule Sarcolemma Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Cation-transporting ATPase Complex Transporter Complex	Golgi Membrane Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Endomembrane System Membrane PML Body Dendrite Cytoplasmic Vesicle TORC1 Complex TORC2 Complex Phagocytic Vesicle Serine/threonine Protein Kinase Complex
	Molecular Function	Protein Binding Calmodulin Binding Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Antiporter Activity Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity Protein Phosphatase 2B Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Calcium-dependent Protein Binding Molecular Adaptor Activity	Nucleotide Binding Inositol Hexakisphosphate Binding RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding TFIIIC-class Transcription Factor Complex Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Ribosome Binding Transmembrane Transporter Binding Protein-containing Complex Binding Phosphoprotein Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of The Force Of Heart Contraction Monoatomic Ion Transport Monoatomic Cation Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Regulation Of PH Response To Acidic PH Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cell Migration Maintenance Of Cell Polarity Cell Differentiation Positive Regulation Of Cell Growth Cellular Response To Insulin Stimulus Positive Regulation Of Mitochondrial Membrane Permeability Response To Muscle Stretch Sodium Ion Export Across Plasma Membrane Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Action Potential Positive Regulation Of Transcription By RNA Polymerase II Stem Cell Differentiation Protein Complex Oligomerization Regulation Of Intracellular PH Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Cardiac Muscle Cell Differentiation Transmembrane Transport Cellular Response To Cold Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Antibiotic Cellular Response To Electrical Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Hypoxia Cellular Response To Acidic PH Potassium Ion Transmembrane Transport Cellular Response To Epinephrine Stimulus Cardiac Muscle Cell Contraction Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of The Force Of Heart Contraction By Cardiac Conduction Sodium Ion Import Across Plasma Membrane Positive Regulation Of The Force Of Heart Contraction Positive Regulation Of Intracellular Signal Transduction Proton Transmembrane Transport	Autophagosome Assembly Regulation Of Cell Growth Cytoplasmic Translation T-helper 1 Cell Lineage Commitment Heart Morphogenesis Heart Valve Morphogenesis Energy Reserve Metabolic Process 'de Novo' Pyrimidine Nucleobase Biosynthetic Process Regulation Of Translational Initiation Ubiquitin-dependent Protein Catabolic Process Inflammatory Response DNA Damage Response Cytoskeleton Organization Lysosome Organization Germ Cell Development Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Regulation Of Cell Size Cellular Response To Starvation Response To Heat Response To Virus Post-embryonic Development Positive Regulation Of Biosynthetic Process Regulation Of Autophagy Negative Regulation Of Autophagy Positive Regulation Of Autophagy Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Myotube Differentiation Macroautophagy Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Regulation Of Lipid Metabolic Process Neuronal Action Potential Cell Projection Organization Positive Regulation Of Cell Growth Positive Regulation Of Actin Filament Polymerization SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process T Cell Costimulation Ruffle Organization Regulation Of Myelination Protein Destabilization Response To Nutrient Levels Cellular Response To Nutrient Levels Cellular Response To Nutrient TOR Signaling Response To Insulin Cellular Response To Insulin Stimulus Regulation Of Actin Cytoskeleton Organization Calcineurin-NFAT Signaling Cascade Cellular Response To Amino Acid Starvation Multicellular Organism Growth TORC1 Signaling TORC2 Signaling Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Response To Amino Acid Anoikis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Differentiation Regulation Of Osteoclast Differentiation Positive Regulation Of Translation Negative Regulation Of Cell Size Positive Regulation Of Glycolytic Process Negative Regulation Of Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase III Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Behavioral Response To Pain Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Cardiac Muscle Tissue Development Protein Stabilization Voluntary Musculoskeletal Movement Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Keratinocyte Migration Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cardiac Cell Development Cardiac Muscle Cell Development Cardiac Muscle Contraction Cellular Response To Methionine Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Amino Acid Stimulus Cellular Response To L-leucine Cellular Response To Hypoxia Cellular Response To Osmotic Stress Regulation Of Cellular Response To Stress Regulation Of Membrane Permeability Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Antibacterial Innate Immune Response Regulation Of Cellular Response To Heat Negative Regulation Of Protein Localization To Nucleus Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of TORC2 Signaling Regulation Of Locomotor Rhythm Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Cytoplasmic Translational Initiation Regulation Of Lysosome Organization Negative Regulation Of Lysosome Organization Positive Regulation Of Pentose-phosphate Shunt Cellular Response To Leucine Starvation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cytoplasmic Translation Regulation Of Autophagosome Assembly
Pathways		Hyaluronan degradation Sodium/Proton exchangers	PIP3 activates AKT signaling Macroautophagy MTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of PTEN gene transcription Amino acids regulate mTORC1 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Amiloride Homoserine Lactone Cariporide	Pimecrolimus Sirolimus Everolimus Rimiducid SF1126 XL765 Ridaforolimus Temsirolimus GSK-1059615 Fostamatinib Oleandrin
Diseases
GWAS		Lateral ventricle volume ( 31530798)	A body shape index ( 34021172) Beard thickness ( 26926045) Body mass index ( 25673413) Body mass index and type 2 diabetes (pairwise) ( 33619380) Corneal curvature ( 24963161) Heel bone mineral density ( 28869591) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		15 interacting genes: CA2 CHP1 CHP2 DAXX MAP3K14 MAP4K4 MAPK1 MAPK14 MDFI MTOR SDHB SLC45A1 TESC WNK1 YWHAB	68 interacting genes: AKT1 AKT1S1 AMBRA1 BCL2L1 C7orf25 CA6 CDC37 CFP CLIP1 DCP2 EIF3F EIF4EBP1 EIF4EBP2 EP300 ESR1 FBXO8 FKBP1A FKBP8 FLNA GPHN GSK3B HRAS IRS1 MAF1 MAPKAP1 MECR MLST8 NPPB NRAS PA2G4 PCNA PDPK1 PIK3CD PLD2 PLEKHM1 PPP2R2A PREX1 PRKAA1 PRKCA PRKN PRR5L RAB1A RHEB RHEBL1 RICTOR RPS6 RPS6KA1 RPS6KA3 RPS6KB1 RPS6KB2 RPTOR RRAGB SEPTIN2 SKP2 SLC2A5 SLC45A1 SLC9A1 STAT3 SUMO1 TELO2 TERT TRAF6 UBQLN1 ULK1 UVRAG WIPI2 YWHAQ ZNRF2
Entrez ID		6548	2475
HPRD ID		00123	03134
Ensembl ID		ENSG00000090020	ENSG00000198793
Uniprot IDs		B2RAH2 P19634	A0A8V8TQ52 P42345
PDB IDs		1Y4E 2BEC 2E30 2HTG 2KBV 2L0E 2MDF 2YGG 6BJF 6NUC 6NUF 6NUU 6ZBI 7DSV 7DSW 7DSX	1AUE 1FAP 1NSG 2FAP 2GAQ 2NPU 2RSE 3FAP 3JBZ 4DRH 4DRI 4DRJ 4FAP 4JSN 4JSP 4JSV 4JSX 4JT5 4JT6 5FLC 5GPG 5H64 5WBH 5WBU 5WBY 5ZCS 6BCU 6BCX 6M4U 6M4W 6SB0 6SB2 6ZWM 6ZWO 7EPD 7OWG 7PE7 7PE8 7PE9 7PEA 7PEB 7PEC 7TZO 7UXC 7UXH 8ER6 8ER7 8ERA 8PPZ 8RCH 8RCK 8RCN 9F44 9F45
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleocytoplasmic Transport Regulation Of Intracellular Transport Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization To Nucleus Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity MAPK Cascade Positive Regulation Of Sodium:proton Antiporter Activity Protein Kinase Activity Regulation Of Cellular Localization Intracellular Signaling Cassette Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcineurin-mediated Signaling Regulation Of Sodium Ion Transmembrane Transport Regulation Of Intracellular Protein Transport Protein Kinase Inhibitor Activity Kinase Activity Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Transport Regulation Of Phosphatase Activity Regulation Of Sodium Ion Transport Negative Regulation Of Protein Localization Positive Regulation Of Keratinocyte Migration Intracellular Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cellular PH Positive Regulation Of Myotube Differentiation Regulation Of Protein Localization Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcium-mediated Signaling Regulation Of PH Positive Regulation Of Cell Migration MAP Kinase Activity Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Motility Regulation Of Intracellular Signal Transduction Positive Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Biosynthetic Process Negative Regulation Of Protein Import Into Nucleus Regulation Of RNA Metabolic Process Positive Regulation Of Locomotion Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Phosphate Metabolic Process Pyrimidine Nucleobase Metabolic Process Negative Regulation Of Calcium-mediated Signaling Stress-activated MAPK Cascade	TOR Signaling Intracellular Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction TORC1 Signaling Regulation Of Autophagy Intracellular Signaling Cassette Regulation Of TOR Signaling TORC2 Signaling Autophagosome Assembly Autophagosome Organization Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Apoptotic Process Cellular Response To Nutrient Levels Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Positive Regulation Of Catabolic Process Positive Regulation Of TOR Signaling Regulation Of Signaling Regulation Of Cell Communication Vacuole Organization Cytoplasm Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Autophagy Regulation Of Translational Initiation Negative Regulation Of Translational Initiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Translation Positive Regulation Of Translational Initiation Insulin Receptor Signaling Pathway Regulation Of Biological Quality Protein Kinase Binding Positive Regulation Of Endothelial Cell Proliferation Regulation Of TORC1 Signaling Response To Nutrient Levels Organelle Organization Positive Regulation Of TORC1 Signaling Positive Regulation Of Cell Population Proliferation Signal Transduction Positive Regulation Of Cell Growth Regulation Of Cellular Component Organization Negative Regulation Of Catabolic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
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