SFTPB and GRPEL1

		SFTPB	GRPEL1
Description		surfactant protein B	GrpE like 1, mitochondrial
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Lysosome Multivesicular Body Endoplasmic Reticulum Membrane Lamellar Body Clathrin-coated Endocytic Vesicle Alveolar Lamellar Body Multivesicular Body Lumen	PAM Complex, Tim23 Associated Import Motor Nucleoplasm Mitochondrion Mitochondrial Inner Membrane TIM23 Mitochondrial Import Inner Membrane Translocase Complex Mitochondrial Matrix
	Molecular Function	Protein Binding	Adenyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Unfolded Protein Binding Protein-folding Chaperone Binding
	Biological Process	Lipid Metabolic Process Sphingolipid Metabolic Process Respiratory Gaseous Exchange By Respiratory System Animal Organ Morphogenesis	Protein Folding Intracellular Protein Transport Protein Import Into Mitochondrial Matrix
Pathways		Surfactant metabolism Defective pro-SFTPB causes SMDP1 and RDS Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4	Mitochondrial protein import
Drugs
Diseases		Pulmonary surfactant metabolism dysfunction (SMDP)
GWAS		Blood protein levels ( 30072576)	Eosinophil percentage of white cells ( 32888494)
Interacting Genes		3 interacting genes: CTSH GRPEL1 MEOX2	14 interacting genes: CCDC57 DSP ERCC6 FAM184B FGFBP2 GALT ISG15 MED28 NKX3-2 POLR1C SFTPB SPG21 WBP2 XYLB
Entrez ID		6439	80273
HPRD ID		01523	07550
Ensembl ID		ENSG00000168878	ENSG00000109519
Uniprot IDs		P07988	Q9HAV7
PDB IDs		1DFW 1KMR 1RG3 1RG4 1SSZ 2DWF 2JOU 2M0H 2M1T	9BLS 9BLT 9BLU
Enriched GO Terms of Interacting Partners?		Kininogen Binding HLA-A Specific Activating MHC Class I Receptor Activity Bradykinin Catabolic Process Neuropeptide Catabolic Process Alveolar Lamellar Body Outer Dense Fiber Response To Odorant Peptidase Activator Activity Involved In Apoptotic Process Multivesicular Body Lumen Thyroid Hormone Binding Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Somite Specification PAM Complex, Tim23 Associated Import Motor Lysosomal Protein Catabolic Process Cellular Response To Thyroid Hormone Stimulus Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Protein Catabolic Process In The Vacuole Segment Specification Somite Development TIM23 Mitochondrial Import Inner Membrane Translocase Complex Adenyl-nucleotide Exchange Factor Activity Peptide Catabolic Process Surfactant Homeostasis T Cell Mediated Cytotoxicity Response To Thyroid Hormone Protein Import Into Mitochondrial Matrix Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Aminopeptidase Activity T Cell Mediated Immunity Membrane Protein Proteolysis Metanephros Development Zymogen Activation Protein Localization To Mitochondrion
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