SDHB and CA6

		SDHB	CA6
Description		succinate dehydrogenase complex iron sulfur subunit B	carbonic anhydrase 6
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Plasma Membrane Membrane Mitochondrial Membrane Respiratory Chain Complex II (succinate Dehydrogenase)	Extracellular Region Extracellular Space Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Succinate Dehydrogenase (quinone) Activity Electron Transfer Activity Oxidoreductase Activity Metal Ion Binding Ubiquinone Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding 3 Iron, 4 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	Carbonate Dehydratase Activity Zinc Ion Binding Lyase Activity Metal Ion Binding
	Biological Process	Tricarboxylic Acid Cycle Succinate Metabolic Process Mitochondrial Electron Transport, Succinate To Ubiquinone Aerobic Respiration Respiratory Electron Transport Chain Proton Motive Force-driven Mitochondrial ATP Synthesis	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste
Pathways		Respiratory electron transport Citric acid cycle (TCA cycle) Maturation of TCA enzymes and regulation of TCA cycle	Reversible hydration of carbon dioxide
Drugs		2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Ubiquinone Q1	Benzthiazide Cyclothiazide Zonisamide Mafenide Ellagic acid
Diseases
GWAS		A body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 20189936) Hip circumference adjusted for BMI ( 34021172) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172)	Blood protein levels ( 30072576) Post bronchodilator FEV1 ( 26634245)
Interacting Genes		17 interacting genes: ABCA1 CA6 CARTPT FLOT1 GEM MFAP2 MSRA PIK3R5 RAP1GAP RPL11 SLC45A1 SLC9A1 SPRY2 STMN1 TARBP1 TMEM132D XRN1	7 interacting genes: FCGRT KRT31 KRT40 MTOR NOTCH2NLA SDHB SLC45A1
Entrez ID		6390	765
HPRD ID		01707	00264
Ensembl ID		ENSG00000117118	ENSG00000131686
Uniprot IDs		A0AAQ5BHD9 P21912	B4DUH8 P23280
PDB IDs		7KCL 7KCM 7KLU 7KLV 8GS8	3FE4
Enriched GO Terms of Interacting Partners?		Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Rho Protein Signal Transduction	IgG Immunoglobulin Transcytosis In Epithelial Cells Mediated By FcRn Immunoglobulin Receptor Regulation Of Locomotor Rhythm TFIIIC-class Transcription Factor Complex Binding Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization 3 Iron, 4 Sulfur Cluster Binding Sucrose Transport D-glucose:proton Symporter Activity Sucrose:proton Symporter Activity Galactose:proton Symporter Activity Immunoglobulin Transcytosis In Epithelial Cells Positive Regulation Of Pentose-phosphate Shunt Inositol Hexakisphosphate Binding RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding Negative Regulation Of TORC2 Signaling Negative Regulation Of Lysosome Organization T-helper 1 Cell Lineage Commitment Respiratory Chain Complex II (succinate Dehydrogenase) Succinate Dehydrogenase (quinone) Activity Galactose Transmembrane Transport Positive Regulation Of Cytoplasmic Translational Initiation TORC1 Complex Energy Derivation By Oxidation Of Organic Compounds Regulation Of Pentose-phosphate Shunt Cellular Response To Methionine Voluntary Musculoskeletal Movement 'de Novo' Pyrimidine Nucleobase Biosynthetic Process RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Intermediate Filament Structural Molecule Activity Mitochondrial Electron Transport, Succinate To Ubiquinone Ubiquinone Binding Response To Methionine Succinate Metabolic Process Beta-2-microglobulin Binding Regulation Of NADP Metabolic Process Pyrimidine Nucleobase Biosynthetic Process Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I TORC2 Complex Negative Regulation Of Cell Size Vascular Endothelial Cell Response To Laminar Fluid Shear Stress
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