ABCD3 and ACADM

		ABCD3	ACADM
Description		ATP binding cassette subfamily D member 3	acyl-CoA dehydrogenase medium chain
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GO Annotations	Cellular Component	Mitochondrion Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol Membrane	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Axon Mitochondrial Membrane
	Molecular Function	Nucleotide Binding Long-chain Fatty Acid Transmembrane Transporter Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity ATPase-coupled Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity Fatty Acyl-CoA Hydrolase Activity ABC-type Transporter Activity	Acyl-CoA Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Identical Protein Binding Flavin Adenine Dinucleotide Binding Medium-chain Fatty Acyl-CoA Dehydrogenase Activity
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Fatty Acid Beta-oxidation Bile Acid Biosynthetic Process Lipid Transport Peroxisome Organization Response To Xenobiotic Stimulus Bile Acid And Bile Salt Transport Long-chain Fatty Acid Import Into Peroxisome Very Long-chain Fatty Acid Catabolic Process Transmembrane Transport Phytanic Acid Metabolic Process	Liver Development Glycogen Biosynthetic Process Organic Acid Metabolic Process Regulation Of Gluconeogenesis Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Heart Development Response To Cold Carnitine Metabolic Process Post-embryonic Development Carnitine Metabolic Process, CoA-linked Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase Response To Starvation Carnitine Biosynthetic Process Medium-chain Fatty Acid Metabolic Process Medium-chain Fatty Acid Catabolic Process Cardiac Muscle Cell Differentiation
Pathways		ABC transporters in lipid homeostasis RHOA GTPase cycle RHOC GTPase cycle Class I peroxisomal membrane protein import	PPARA activates gene expression mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA
Drugs			Octanoyl-Coenzyme A Flavin adenine dinucleotide 3-thiaoctanoyl-CoA
Diseases			Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)
GWAS			Daytime sleep phenotypes ( 27126917) Glycine levels ( 30837465 31070104) Metabolic traits ( 21886157) Metabolite levels ( 20037589) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 23093944 33031748) Serum metabolite ratios in chronic kidney disease ( 29545352) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)
Interacting Genes		8 interacting genes: ABCD1 ABCD2 ACADM COL6A2 PEX19 PSMA1 TUFT1 UBC	10 interacting genes: ABCD3 AGTR1 CALM1 CDC42 DBT DIRAS3 DYNC1I1 MSH4 PANK1 SUMO4
Entrez ID		5825	34
HPRD ID		01368	08447
Ensembl ID		ENSG00000117528	ENSG00000117054
Uniprot IDs		P28288	A0A0S2Z366 B4DJE7 B7Z9I1 P11310 Q5T4U5
PDB IDs		8Z0F 8Z9X	1EGC 1EGD 1EGE 1T9G 2A1T 4P13 8SGP
Enriched GO Terms of Interacting Partners?		Peroxisomal Membrane Transport Organophosphate Ester Transmembrane Transporter Activity Nucleobase-containing Compound Transmembrane Transporter Activity Peroxisome Organization Sulfur Compound Transmembrane Transporter Activity Amide Transmembrane Transporter Activity Long-chain Fatty Acid Import Into Peroxisome Fatty Acid Beta-oxidation Peroxisomal Membrane Very Long-chain Fatty Acid Catabolic Process Fatty Acid Oxidation Fatty Acid Catabolic Process Lipid Oxidation Positive Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process Neuron Projection Maintenance Positive Regulation Of Fatty Acid Oxidation Fatty Acyl-CoA Hydrolase Activity Myelin Maintenance Alpha-linolenic Acid Metabolic Process Peroxisome Long-chain Fatty Acid Transmembrane Transporter Activity Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Lipid Modification Linoleic Acid Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Lipid Catabolic Process ATPase-coupled Transmembrane Transporter Activity Regulation Of Fatty Acid Oxidation Carboxylic Acid Catabolic Process Very Long-chain Fatty Acid Metabolic Process Intracellular Lipid Transport Long-chain Fatty Acid Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Fatty Acid Metabolic Process ABC-type Transporter Activity Regulation Of Reactive Oxygen Species Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Neuron Projection Organization Lipid Catabolic Process Negative Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Fatty Acid Biosynthetic Process Long-chain Fatty Acid Transport Fatty Acid Derivative Biosynthetic Process Fatty Acid Metabolic Process Regulation Of Lipid Catabolic Process Regulation Of Small Molecule Metabolic Process Very Long-chain Fatty-acyl-CoA Catabolic Process ABC-type Fatty-acyl-CoA Transporter Activity	Intracellular Signaling Cassette Small GTPase-mediated Signal Transduction Angiotensin Type I Receptor Activity Bradykinin Receptor Binding Substantia Nigra Development Negative Regulation Of High Voltage-gated Calcium Channel Activity Neural Nucleus Development Regulation Of Cytokinesis Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Type II Interferon Cytoplasmic Ribonucleoprotein Granule GBD Domain Binding Storage Vacuole Organelle Transport Along Microtubule Dihydrolipoamide Branched Chain Acyltransferase Activity Recombination Nodule Phytanic Acid Metabolic Process Pantothenate Kinase Activity Angiotensin Type II Receptor Activity Phospholipase C-activating Angiotensin-activated Signaling Pathway Renin-angiotensin Regulation Of Aldosterone Production Organelle Localization Response To Type II Interferon Nucleotide Binding Apolipoprotein A-I Receptor Binding Endothelin Receptor Signaling Pathway Involved In Heart Process Neuropilin Signaling Pathway Branched-chain Alpha-keto Acid Decarboxylation To Branched-chain Acyl-CoA Branched-chain Alpha-ketoacid Dehydrogenase Complex Methyl-branched Fatty Acid Metabolic Process Long-chain Fatty Acid Import Into Peroxisome Acetyl-CoA Binding SUMO Ligase Complex
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