PRLR and ICAM3

		PRLR	ICAM3
Description		prolactin receptor	intercellular adhesion molecule 3
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Endosome Lumen Receptor Complex	Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Cytokine Receptor Activity Prolactin Receptor Activity Protein Binding Lipid Binding Peptide Hormone Binding Protein Kinase Binding Cytokine Binding Metal Ion Binding	Signaling Receptor Binding Integrin Binding Protein Binding
	Biological Process	Steroid Biosynthetic Process Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Via JAK-STAT Embryo Implantation Lactation Positive Regulation Of Cell Population Proliferation Response To Bacterium Cytokine-mediated Signaling Pathway Regulation Of Cell Adhesion Regulation Of Epithelial Cell Differentiation Positive Regulation Of B Cell Proliferation Prolactin Signaling Pathway Activation Of Janus Kinase Activity Negative Regulation Of Apoptotic Process Mammary Gland Epithelial Cell Differentiation Prostate Gland Growth Mammary Gland Alveolus Development Mammary Gland Epithelium Development Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Cold-induced Thermogenesis	Phagocytosis Cell Adhesion Cell-cell Adhesion
Pathways		Prolactin receptor signaling Prolactin receptor signaling Growth hormone receptor signaling	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions CD209 (DC-SIGN) signaling
Drugs		Somatotropin Lonapegsomatropin
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Appendicular lean mass ( 33097823) Chronotype ( 30696823) DHEAS levels ( 34748635) Metabolite levels ( 23823483) Paneth cell defects in Crohn's disease ( 28352666) Psychotic experience ( 31553412) Response to lurasidone in schizophrenia ( 29730043)	Crohn's disease ( 21102463 28067908) Inflammatory bowel disease ( 28067908) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031)
Interacting Genes		22 interacting genes: CISH CREBBP CSH1 FBXW11 GH1 ICAM3 INSIG2 JAK2 MFGE8 NEK3 PLPP6 PPIA PRL PTPN11 SOCS2 SOCS3 TEC VAV1 VAV2 YWHAG YWHAZ ZAP70	29 interacting genes: APP BRICD5 C3 CALR CD209 CLDN19 CLDN4 CLEC4M EDDM3B EPOR EZR GCC2 ITGAD ITGAL ITGB2 MSN NINJ2 PRKCQ PRLR RFX2 RPL18 SEC22A SFTPC SMCO4 SMIM1 TNFRSF1B TSPO USF2 ZBTB16
Entrez ID		5618	3385
HPRD ID		01457	00889
Ensembl ID		ENSG00000113494	ENSG00000076662
Uniprot IDs		P16471	A0A9L9PXS1 P32942
PDB IDs		1BP3 2LFG 2N7I 3D48 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF 4I18	1T0P
Enriched GO Terms of Interacting Partners?		Regulation Of Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Binding Protein Modification Process Regulation Of Signal Transduction Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Protein Metabolic Process Endosome Lumen Growth Hormone Receptor Signaling Pathway Intracellular Signal Transduction Vesicle Positive Regulation Of Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Phosphorylation-dependent Protein Binding Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune Response Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Prolactin Receptor Binding Positive Regulation Of Immune System Process Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Negative Regulation Of Signal Transduction Cytokine Receptor Binding Developmental Process Negative Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Activation Regulation Of Immune System Process Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation Macromolecule Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Sequestering Activity	Leukocyte Cell-cell Adhesion Cell-cell Adhesion ICAM-3 Receptor Activity Cell Surface Cell Adhesion External Side Of Plasma Membrane Integrin AlphaL-beta2 Complex Peptide Antigen Transport Integrin Complex Membrane Cell Adhesion Molecule Binding Regulation Of Immune System Process Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Membrane To Membrane Docking Cell Recognition Paracellular Transport Intracellular Transport Of Virus Endocytosis Positive Regulation Of Early Endosome To Late Endosome Transport Host Cell Positive Regulation Of Protein Localization To Early Endosome Cell-cell Recognition Virion Binding Regulation Of Nitric Oxide Biosynthetic Process Virion Attachment To Host Cell Regulation Of Transport Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Protein Localization To Endosome Adhesion Of Symbiont To Host Cell Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Immune System Process Uropod Plasma Membrane Regulation Of Cell Population Proliferation Response To Manganese Ion Neuron Remodeling Adhesion Of Symbiont To Host Positive Regulation Of Multicellular Organismal Process Regulation Of Vesicle-mediated Transport Leukocyte Activation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Transport Specific Granule Membrane Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Protein Catabolic Process Cellular Extravasation Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Cell Activation Import Into Cell Vesicle-mediated Transport
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