GPRC5C and CLCN3

		GPRC5C	CLCN3
Description		G protein-coupled receptor class C group 5 member C	chloride voltage-gated channel 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cilium Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Vesicle Centriolar Satellite Intracellular Membrane-bounded Organelle Receptor Complex Extracellular Exosome	Golgi Membrane Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Synaptic Vesicle External Side Of Plasma Membrane Cell Surface Endosome Membrane Vesicle Membrane Membrane Secretory Granule Synaptic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Ruffle Membrane Specific Granule Cell Projection Axon Terminus Phagocytic Vesicle Recycling Endosome Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	G Protein-coupled Receptor Activity Protein Kinase Activator Activity	Nucleotide Binding Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Chloride Transmembrane Transporter Activity Antiporter Activity PDZ Domain Binding Chloride:proton Antiporter Activity Volume-sensitive Chloride Channel Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway	Monoatomic Ion Transport Chloride Transport Regulation Of PH Phagocytosis, Engulfment Adult Locomotory Behavior Synaptic Transmission, Glutamatergic Photoreceptor Cell Maintenance Negative Regulation Of Cell Volume Endosomal Lumen Acidification Synaptic Transmission, GABAergic Transmembrane Transport Neuron Cellular Homeostasis Synaptic Vesicle Lumen Acidification Chloride Transmembrane Transport Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Pathways			Stimuli-sensing channels
Drugs
Diseases
GWAS		LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Liver enzyme levels (alkaline phosphatase) ( 33972514)	Autism spectrum disorder or schizophrenia ( 28540026) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Schizophrenia ( 25056061 28991256 29483656 30285260)
Interacting Genes		3 interacting genes: ABHD16A APPBP2 CLCN3	17 interacting genes: ANXA10 CFTR DECR1 DNAJC5 ETFDH FZD3 GOPC GPRC5C GRIA2 HPF1 HSPB1 MED23 NEK1 NHERF1 PDGFB PDZK1 VPS18
Entrez ID		55890	1182
HPRD ID		16178	02785
Ensembl ID		ENSG00000170412	ENSG00000109572
Uniprot IDs		A0A0C4DFY5 A8MXZ4 Q9BSP0 Q9NQ84	B3KXK0 E9PE15 P51790
PDB IDs
Enriched GO Terms of Interacting Partners?		Chloride:proton Antiporter Activity Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Negative Regulation Of Cell Volume Volume-sensitive Chloride Channel Activity Monoacylglycerol Catabolic Process Chloride Transmembrane Transporter Activity Synaptic Vesicle Lumen Acidification Specific Granule Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Endosomal Lumen Acidification Voltage-gated Chloride Channel Activity Monoacylglycerol Lipase Activity Phosphatidylserine Metabolic Process Cul2-RING Ubiquitin Ligase Complex Phosphatidylcholine Lysophospholipase Activity Phospholipase Activity Acylglycerol Catabolic Process Glycerophospholipid Catabolic Process Phagocytosis, Engulfment Modified Amino Acid Catabolic Process Synaptic Transmission, GABAergic Cell Volume Homeostasis Vesicle Membrane Microtubule Associated Complex Photoreceptor Cell Maintenance Regulation Of Reactive Oxygen Species Biosynthetic Process Phospholipid Catabolic Process Synaptic Transmission, Glutamatergic Membrane Invagination Intracellular PH Reduction Axon Terminus Microtubule Motor Activity Neuron Cellular Homeostasis	Regulation Of Monoatomic Anion Transport PDZ Domain Binding Chloride Channel Regulator Activity Regulation Of Monoatomic Ion Transport Golgi-associated Vesicle Membrane 14-3-3 Protein Binding Apical Plasma Membrane Regulation Of Transport Lysosomal Membrane Microvillus Membrane Protein-membrane Adaptor Activity Vesicle Docking Involved In Exocytosis Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Negative Regulation Of Protein Kinase C Signaling Metanephric Glomerular Mesangial Cell Development Renal Phosphate Ion Absorption Negative Regulation Of Anion Channel Activity
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