SHFL and FBXL12

		SHFL	FBXL12
Description		shiftless antiviral inhibitor of ribosomal frameshifting	F-box and leucine rich repeat protein 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Cytosol	Ubiquitin Ligase Complex Cytoplasm Cytosol
	Molecular Function	RNA Binding Protein Binding Identical Protein Binding Ribosome Binding Sequence-specific MRNA Binding	Protein Binding
	Biological Process	Regulation Of Translational Termination Response To Type I Interferon Response To Type II Interferon Response To Type III Interferon Response To Interferon-beta Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Viral Translational Frameshifting Negative Regulation Of Translational Frameshifting	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination
Pathways			Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Pursuit maintenance gain ( 29064472)
Interacting Genes		67 interacting genes: ADAMTSL4 CADPS CCDC136 CCNDBP1 CYSRT1 DRICH1 DTNBP1 DVL3 ECSIT FBXL12 FHL5 HSF2BP IKZF1 INCA1 KLF15 KRT31 KRT40 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 LNX1 LURAP1 LZTS2 MAGEA1 MDFI MEOX2 MID2 MTUS2 NBPF19 NOTCH2NLA PCSK5 PDE4DIP PICK1 PPP2R5A SPRY2 SSX2IP TCF4 TENM4 TERF1 TLE5 TNS2 TRAF1 TRIB3 TRIM42 TRIM55 TRIM63 VWC2 ZNF835	24 interacting genes: A2M ALDH3A1 APOE CDC37 CDKN1C DOCK8 ECSIT FBF1 FXYD3 GEMIN4 LNX1 MARCHF2 MAST1 PSEN1 PSEN2 PSME3 RNF32 SHFL SMAD1 TGFBR1 UBE2D3 ZNF44 ZNF562 ZNF823
Entrez ID		55337	54850
HPRD ID		07747	12363
Ensembl ID		ENSG00000130813	ENSG00000127452
Uniprot IDs		Q9NUL5	Q9NXK8
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Hair Cycle Identical Protein Binding Cytosol Protein Binding Interstitial Matrix	Amyloid Precursor Protein Metabolic Process Positive Regulation Of Amyloid Fibril Formation Aspartic Endopeptidase Activity, Intramembrane Cleaving Gamma-secretase Complex Notch Receptor Processing Amyloid-beta Formation Regulation Of Amyloid Fibril Formation I-SMAD Binding Amyloid Precursor Protein Catabolic Process
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