ACP3 and EPHB1

		ACP3	EPHB1
Description		acid phosphatase 3	EPH receptor B1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Lysosomal Membrane Multivesicular Body Cytosol Plasma Membrane Vesicle Membrane Membrane Secretory Granule Filopodium Golgi Cisterna Azurophil Granule Membrane Apical Part Of Cell Extracellular Exosome	Extracellular Region Cytoplasm Endosome Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Axon Dendrite Early Endosome Membrane Filopodium Tip Cell Projection Membrane Raft Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Acid Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding 5'-nucleotidase Activity Hydrolase Activity Phosphatase Activity Choline Binding Thiamine Phosphate Phosphatase Activity Identical Protein Binding Protein Homodimerization Activity Lysophosphatidic Acid Phosphatase Activity Molecular Adaptor Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Kinase Activity Transferase Activity Protein-containing Complex Binding
	Biological Process	Purine Nucleobase Metabolic Process Lipid Metabolic Process Thiamine Metabolic Process Nucleotide Metabolic Process Adenosine Metabolic Process Regulation Of Sensory Perception Of Pain Positive Regulation Of Adenosine Receptor Signaling Pathway	Angiogenesis Immunological Synapse Formation Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Skeletal Muscle Satellite Cell Activation Cell Migration Cranial Nerve Development Optic Nerve Morphogenesis Hindbrain Tangential Cell Migration Central Nervous System Projection Neuron Axonogenesis Neurogenesis Establishment Of Cell Polarity Retinal Ganglion Cell Axon Guidance Cell-substrate Adhesion Regulation Of JNK Cascade Protein Autophosphorylation Ephrin Receptor Signaling Pathway Camera-type Eye Morphogenesis System Development Modulation Of Chemical Synaptic Transmission Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Synapse Assembly Cell Chemotaxis Dendritic Spine Development Dendritic Spine Morphogenesis Neural Precursor Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Satellite Cell Differentiation
Pathways		Neutrophil degranulation	EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs		(2R,3R)-2,3-Dihydroxy-4-oxo-4-(propylamino)butanoic acid Alpha-Benzyl-Aminobenzyl-Phosphonic Acid Sipuleucel-T	Chlortetracycline Fostamatinib
Diseases
GWAS			A body shape index ( 34021172) Adult body size ( 32376654) Bitter beverage consumption ( 31046077) CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583) Daytime sleep phenotypes ( 27126917) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Familial lung adenocarcinoma ( 29924316) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Mood instability ( 31168069) Neurofibrillary tangles ( 31497858) Small cell lung carcinoma ( 28604730) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist circumference adjusted for body mass index ( 34021172) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		3 interacting genes: EPHB1 ERBB2 SHBG	23 interacting genes: AADAC ACP1 ACP3 AMOTL2 CTPS1 EFNA1 EFNA5 EFNB1 EFNB2 EPHB6 ERBB2 GM2A GRB10 GRB2 GTF2E1 MBD4 MRPL3 MTDH NCK1 PCCB PRKCG PXN UQCRC2
Entrez ID		55	2047
HPRD ID		01378	02790
Ensembl ID		ENSG00000014257	ENSG00000154928
Uniprot IDs		P15309	P54762
PDB IDs		1CVI 1ND5 1ND6 2HPA 2L3H 2L77 2L79 2MG0 3PPD 7ZZV 8XJ4	2DJS 2EAO 3ZFX 5MJA 5MJB 6UMW 7KPL 7KPM
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Optic Nerve Morphogenesis Negative Regulation Of Skeletal Muscle Cell Proliferation Negative Regulation Of Satellite Cell Differentiation Regulation Of ERK1 And ERK2 Cascade Neuron Projection Guidance Hindbrain Tangential Cell Migration Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Axon Guidance Protein Tyrosine Kinase Activity Negative Regulation Of Immature T Cell Proliferation In Thymus RNA Polymerase I Core Binding ErbB-3 Class Receptor Binding ERBB3:ERBB2 Complex Immature T Cell Proliferation In Thymus ERBB2-ERBB4 Signaling Pathway Androgen Binding Skeletal Muscle Satellite Cell Activation Negative Regulation Of Immature T Cell Proliferation Negative Regulation Of Skeletal Muscle Cell Differentiation Protein Phosphorylation Phosphorylation ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB2-EGFR Signaling Pathway ERBB4 Signaling Pathway Regulation Of Skeletal Muscle Cell Proliferation Transmembrane-ephrin Receptor Activity Neuron Projection Development Cell Migration In Hindbrain Axon Guidance Receptor Activity Immunological Synapse Formation Cranial Nerve Morphogenesis Dendritic Spine Development Protein Kinase Activity Regulation Of Skeletal Muscle Satellite Cell Proliferation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Activity Negative Regulation Of T Cell Differentiation In Thymus Semaphorin Receptor Complex Regulation Of Immature T Cell Proliferation In Thymus Filopodium Tip Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Dendritic Spine Morphogenesis Nervous System Development Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Enzyme-linked Receptor Protein Signaling Pathway Detection Of Temperature Stimulus Central Nervous System Projection Neuron Axonogenesis	Ephrin Receptor Binding Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Neuron Projection Guidance Axon Guidance Cell Surface Receptor Signaling Pathway Vesicle Membrane Acid Phosphatase Activity Neuron Projection Development Neurotrophin TRKA Receptor Binding T Cell Costimulation T Cell Activation Regulation Of Cell-cell Adhesion Signal Complex Assembly Regulation Of Cell Adhesion Plasma Membrane Bounded Cell Projection Organization Pyrimidine-containing Compound Metabolic Process T Cell Proliferation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Cell-cell Junction Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Schwann Cell Development Lymphocyte Activation Positive Regulation Of Phosphorylation Positive Regulation Of T Cell Activation Cell Projection Organization Positive Regulation Of Cell Adhesion Lymphocyte Proliferation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Lymphocyte Activation Mononuclear Cell Proliferation Leukocyte Activation Positive Regulation Of Phosphate Metabolic Process Presynaptic Membrane Leukocyte Proliferation Cell Migration Positive Regulation Of Cell-cell Adhesion Insulin-like Growth Factor Receptor Signaling Pathway Signaling Receptor Complex Adaptor Activity Positive Regulation Of Lymphocyte Activation Regulation Of Actin Cytoskeleton Organization Thiamine Phosphate Phosphatase Activity Signal Transduction Neurotrophin TRKC Receptor Binding Neurotrophin TRKB Receptor Binding Sphingolipid Activator Protein Activity Beta-N-acetylgalactosaminidase Activity Guanyl-nucleotide Exchange Factor Adaptor Activity
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