GON4L and ATP6V1A

		GON4L	ATP6V1A
Description		gon-4 like	ATPase H+ transporting V1 subunit A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V1 Domain Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Plasma Membrane Microvillus Endosome Membrane Membrane Apical Plasma Membrane Proton-transporting Two-sector ATPase Complex Transport Vesicle Secretory Granule Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase, V1 Domain Extracellular Exosome Extrinsic Component Of Synaptic Vesicle Membrane ATPase Complex
	Molecular Function	Transcription Coregulator Activity	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Regulation Of DNA-templated Transcription	Monoatomic Ion Transport Intracellular Iron Ion Homeostasis Vacuolar Acidification Lysosomal Lumen Acidification Regulation Of Macroautophagy Cellular Response To Increased Oxygen Levels Homeostatic Process ATP Metabolic Process Endosomal Lumen Acidification Intracellular PH Reduction Golgi Lumen Acidification Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport
Pathways			ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Drugs			Alendronic acid Etidronic acid Tiludronic acid Bafilomycin A1 Bafilomycin B1
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28892062) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Lewy body disease ( 25188341) Neuritic plaque ( 31497858) Periventricular white matter hyperintensities ( 32517579) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels ( 31578528)	Prostate cancer ( 23535732)
Interacting Genes		2 interacting genes: ITGB5 USP7	7 interacting genes: ANXA7 CDC42 CDKN1A SMN1 TK1 TUFM UBC
Entrez ID		54856	523
HPRD ID		13370	06120
Ensembl ID		ENSG00000116580	ENSG00000114573
Uniprot IDs		A4PB67 A4PB68 Q14BN2 Q3T8J9 Q9H986	P38606
PDB IDs			6WLZ 6WM2 6WM3 6WM4 7U4T 7UNF
Enriched GO Terms of Interacting Partners?		ATPase Complex Proton-transporting V-type ATPase, V1 Domain Extrinsic Component Of Synaptic Vesicle Membrane Proton-transporting Two-sector ATPase Complex Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V1 Domain Endosomal Lumen Acidification Regulation Of Autophagy Cellular Response To Increased Oxygen Levels Wound Healing, Spreading Of Epidermal Cells Integrin Alphav-beta5 Complex Regulation Of Establishment Of Protein Localization To Chromosome Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Monoubiquitinated Protein Deubiquitination Regulation Of Establishment Of Protein Localization To Telomere DNA Alkylation Repair Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Telomere Capping Regulation Of Retrograde Transport, Endosome To Golgi Transcription-coupled Nucleotide-excision Repair Synaptic Vesicle Lumen Acidification Proton-transporting V-type ATPase Complex Epithelial Cell-cell Adhesion K48-linked Deubiquitinase Activity Negative Regulation Of Gluconeogenesis Proton-transporting ATPase Activity, Rotational Mechanism Lysosomal Lumen Acidification Stress Fiber Assembly Contractile Actin Filament Bundle Assembly Deubiquitinase Activity Integrin Complex Cell Adhesion Mediated By Integrin Wound Healing, Spreading Of Cells Regulation Of Lysosomal Lumen PH Clathrin-coated Vesicle Membrane Endodermal Cell Differentiation Vacuolar Acidification
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