PPID and LARP1

		PPID	LARP1
Description		peptidylprolyl isomerase D	La ribonucleoprotein 1, translational regulator
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cilium	Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane TORC1 Complex
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Transcription Factor Binding Cyclosporin A Binding Isomerase Activity Nuclear Estrogen Receptor Binding Hsp70 Protein Binding Heat Shock Protein Binding Hsp90 Protein Binding	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Activator Activity Translation Initiation Factor Binding Ribosomal Small Subunit Binding Cadherin Binding MRNA 5'-UTR Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Folding Apoptotic Process Protein Transport Viral Release From Host Cell Lipid Droplet Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Viral Genome Replication Positive Regulation Of Protein Secretion Protein-containing Complex Assembly Cellular Response To UV-A	Translation Translational Initiation Regulation Of Translation Cell Population Proliferation Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Macroautophagy Negative Regulation Of Translation TOR Signaling TORC1 Signaling Positive Regulation Of Viral Genome Replication Positive Regulation Of Translation Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation MRNA Stabilization Cellular Response To Rapamycin Response To Amino Acid Starvation
Pathways		ESR-mediated signaling	SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Serum metabolite levels ( 23093944)	Chin dimples ( 27182965) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Monobrow ( 27182965) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		21 interacting genes: APP BCL2 CSNK2B ESR1 FBXO25 FES HAP1 HSF1 HSP90AA1 HSP90AB1 HSPA8 KAT7 LARP1 LNX1 PLK1 S100A1 S100A2 S100A6 SLC25A4 SMURF2 TRIM27	17 interacting genes: ATP6AP1 BCL2L1 CEBPA CLNS1A CSNK2A1 KASH5 LCP2 PPID PPL RNF10 SRPK1 TNNT1 UBXN7 YWHAB YWHAG YWHAQ YWHAZ
Entrez ID		5481	23367
HPRD ID		11875	11225
Ensembl ID		ENSG00000171497	ENSG00000155506
Uniprot IDs		E5KN55 Q08752	A0A8I5KSP1 A0A8I5KWU3 Q6PKG0
PDB IDs			4ZC4 5C0V 5V4R 5V7C 5V87 6PW3 7SOO 7SOP 7SOQ 7SOR 7SOS 7SOT 7SOU 7SOV 7SOW 8EY6 8EY7 8EY8 8G90 8G91 8XP2 8XP3
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Positive Regulation Of Nitric Oxide Biosynthetic Process Nitric-oxide Synthase Regulator Activity Protein Folding Chaperone Complex Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Catabolic Process Negative Regulation Of Metabolic Process Cytoplasm Response To Unfolded Protein Regulation Of Protein Import Cytosol MHC Class II Protein Complex Binding Protein Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process ATP-dependent Protein Folding Chaperone Positive Regulation Of Developmental Process Secretory Granule Lumen Ficolin-1-rich Granule Lumen Negative Regulation Of RNA Metabolic Process Regulation Of Viral Process Telomerase Holoenzyme Complex Assembly Protein-containing Complex Chaperone-mediated Autophagy Cellular Response To Heat Regulation Of Protein Localization To Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Dendritic Growth Cone TPR Domain Binding Regulation Of Cellular Component Organization Protein Folding Chaperone Positive Regulation Of Cell Differentiation Regulation Of Primary Metabolic Process Protein Modification Process Heat Shock Protein Binding Regulation Of Multicellular Organism Growth Regulation Of Protein Catabolic Process Regulation Of Protein Localization Regulation Of Protein Stability Protein Ubiquitination Regulation Of Biological Quality Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Catabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Calcium-dependent Protein Binding Regulation Of Metabolic Process	Protein Domain Specific Binding Protein Targeting Protein Sequestering Activity Phosphoserine Residue Binding Establishment Of Protein Localization Intracellular Signal Transduction Identical Protein Binding Cytosol Positive Regulation Of Viral Genome Replication
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