POLR2E and FADS1

		POLR2E	FADS1
Description		RNA polymerase II, I and III subunit E	fatty acid desaturase 1
Image			No pdb structure
GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase II, Core Complex RNA Polymerase III Complex Nucleolus RNA Polymerase I Complex Cytosol RPAP3/R2TP/prefoldin-like Complex	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding DNA-directed RNA Polymerase Activity Protein Binding	C-5 Sterol Desaturase Activity Acyl-CoA 6-desaturase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Oxidation Of A Pair Of Donors Resulting In The Reduction Of Molecular Oxygen To Two Molecules Of Water Omega-6 Fatty Acid Desaturase Activity Acyl-CoA (8-3)-desaturase Activity
	Biological Process	DNA-templated Transcription Transcription Elongation By RNA Polymerase I Transcription By RNA Polymerase II TRNA Transcription By RNA Polymerase III Protein Stabilization	Regulation Of DNA-templated Transcription Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Cell-cell Signaling Phospholipid Biosynthetic Process Cellular Response To Starvation Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Linoleic Acid Metabolic Process Regulation Of Cell Differentiation Icosanoid Biosynthetic Process
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis Cytosolic sensors of pathogen-associated DNA MicroRNA (miRNA) biogenesis NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere	PPARA activates gene expression Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism
Drugs			alpha-Linolenic acid Icosapent
Diseases
GWAS		Cortical amyloid beta load ( 29860282) Menopause (age at onset) ( 26414677)	Alanine transaminase levels ( 29403010) Aortic valve stenosis ( 32186652) Appendicular lean mass ( 33097823) Asthma ( 31619474 31959851 32296059 34103634) Asthma (adult onset) ( 31036433) Bipolar disorder ( 28115744 31043756) Bipolar I disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Breast milk fatty acid composition (infant genotype effect) ( 29514873) Breast milk fatty acid composition (maternal genotype effect) ( 29514873) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Change in serum metabolite levels ( 31636271) Change in serum metabolite levels (CMS) ( 31636271) Cholesterol, total ( 20686565 24097068 25961943) Colorectal cancer ( 24836286) Colorectal cancer or advanced adenoma ( 30510241) Comprehensive strength and appendicular lean mass ( 22960237) Crohn's disease ( 21102463 28067908) Delta-5 desaturase activity response to n3-polyunsaturated fat supplement ( 29246731) Eosinophil count ( 27863252) Fasting blood glucose ( 20081858 22581228 25631608) Fasting blood glucose (BMI interaction) ( 22581228) Fatty acid desaturase activity (adipose tissue) ( 30453627) Fatty acid desaturase activity (serum) ( 30453627) Glycated hemoglobin levels ( 34059833) Gondoic acid (20:1n-9) levels ( 28298293) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 19060906 20686565 20864672 24097068 25961943) HDL cholesterol levels ( 28334899) Heart rate ( 23583979) Height ( 25429064) Hematology traits ( 23303382) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 29615537) Homeostasis model assessment of beta-cell function ( 20081858) Inflammatory bowel disease ( 23128233) Iron status biomarkers (total iron binding capacity) ( 33536631) Laryngeal squamous cell carcinoma ( 25194280) LDL cholesterol ( 19060910 20686565 24097068 25961943 30275531) LDL cholesterol levels ( 28334899) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 22286219) Liver enzyme levels (alkaline phosphatase) ( 22001757 33972514) Male-pattern baldness ( 28196072) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 20694148) Metabolic traits ( 21886157) Metabolite levels ( 19043545 20037589 22916037 23281178 23378610 23823483) Metabolite risk score for predicting weight gain ( 31560688) Monocyte percentage of white cells ( 27863252 32888494) Moyamoya disease ( 29273593) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Oleic acid (18:1n-9) levels ( 23362303 28298293) Palmitoleic acid (16:1n-7) levels ( 23362303 28298293) Phospholipid levels (plasma) ( 22359512) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) PR interval ( 32439900) QT interval ( 30679814) Red blood cell fatty acid levels ( 25500335) Red cell distribution width ( 27863252 32888494) Refractive error ( 32231278) Response to statin therapy ( 20339536) Resting heart rate ( 20639392) Rheumatoid arthritis ( 24390342 30423114) Serum docosahexaenoic fatty acid concentration in metabolic syndrome ( 31991592) Serum metabolite concentrations in chronic kidney disease ( 29545352 33838163) Serum metabolite levels ( 23093944 31636271 33031748) Serum metabolite levels (CMS) ( 31636271) Serum metabolite ratios in chronic kidney disease ( 29545352) Serum omega-3 polyunsaturated fatty acid concentration in metabolic syndrome ( 31991592) Serum omega-6 to omega-3 polyunsaturated fatty acid ratio in metabolic syndrome ( 31991592) Sphingolipid levels ( 22359512) Stearic acid (18:0) levels ( 23362303) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Total cholesterol levels ( 28334899 29615537) Triacylglycerol 56:6 levels ( 31560688) Triglyceride levels ( 28334899 29403010 33339817) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 19060906 20686565 20864672 24097068 25961943) Vaccenic acid (18:1n-7) levels ( 28298293) Vitamin C levels ( 33203707) White blood cell count ( 27863252 32888494) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		33 interacting genes: CHGB DCC FADS1 FKBP14 FOS GTF2F2 HSP90B1 IKBKG IP6K3 ITCH LZTR1 NEDD4 NFIX PML POLR2A POLR2C POLR2D POLR2F POLR2G POLR2H POLR2K POLR2L SRPK1 SYT5 TAF15 TRIM29 TRIM55 TRIM63 TUBGCP2 UBE2D1 UBE2D4 URI1 ZSCAN1	3 interacting genes: EEF1G POLR2E XRN1
Entrez ID		5434	3992
HPRD ID		15946	06935
Ensembl ID		ENSG00000099817	ENSG00000149485
Uniprot IDs		B4DJ89 E5KT65 P19388	A0A0A0MR51 O60427
PDB IDs		5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L 6XRE 7A6H 7AE1 7AE3 7AEA 7AST 7D58 7D59 7DN3 7DU2 7FJI 7FJJ 7LBM 7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43 8ITY 8IUE 8IUH 9EHZ 9EI1 9EI3 9EI4 9FSO 9FSP 9FSQ 9FSR 9FSS
Enriched GO Terms of Interacting Partners?		RNA Polymerase II, Core Complex DNA-directed RNA Polymerase Complex Transcription By RNA Polymerase II DNA-templated Transcription DNA-directed RNA Polymerase Activity RNA Polymerase I Complex RNA Polymerase III Complex Nucleobase-containing Compound Biosynthetic Process RNA Metabolic Process Macromolecule Metabolic Process Macromolecule Biosynthetic Process Nucleus Protein K63-linked Ubiquitination Nucleoplasm Innate Immune Response Transcription By RNA Polymerase III Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Nucleic Acid Metabolic Process Protein K48-linked Ubiquitination Regulation Of RNA Metabolic Process Defense Response To Symbiont Defense Response To Other Organism Transcription Initiation At RNA Polymerase II Promoter Response To External Biotic Stimulus Ubiquitin-protein Transferase Activity Protein Ubiquitination Post-translational Protein Modification Protein Polyubiquitination Response To Other Organism TRNA Transcription By RNA Polymerase III TRNA Transcription Protein K29-linked Ubiquitination Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding DNA-templated Transcription Initiation Transcription By RNA Polymerase I Regulation Of Primary Metabolic Process Nucleobase-containing Compound Metabolic Process Ubiquitin Protein Ligase Activity Protein Modification Process Defense Response Translation Initiation Factor Binding Regulation Of Gene Expression SMAD Protein Signal Transduction Transferase Activity Regulation Of Macromolecule Biosynthetic Process Medium-term Memory Cellular Response To Prolactin	Cellular Response To Puromycin Cellular Response To Cycloheximide TRNA Transcription By RNA Polymerase III RPAP3/R2TP/prefoldin-like Complex Transcription Elongation By RNA Polymerase I 5'-3' Exonuclease Activity Response To Cycloheximide G-quadruplex RNA Binding 5'-3' RNA Exonuclease Activity Nuclear MRNA Surveillance G-quadruplex DNA Binding TRNA Transcription RNA Polymerase I Complex RNA Polymerase III Complex RNA Polymerase II, Core Complex RRNA Catabolic Process Histone MRNA Catabolic Process Translation Elongation Factor Activity Telomerase RNA Binding Negative Regulation Of Telomere Maintenance Via Telomerase Histone MRNA Metabolic Process DNA-directed RNA Polymerase Activity Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Transcription By RNA Polymerase III DNA-directed RNA Polymerase Complex Nuclear RNA Surveillance Negative Regulation Of Telomere Maintenance RNA Surveillance Response To Testosterone Regulation Of Telomere Maintenance Via Telomerase Exonuclease Activity DNA-templated Transcription Elongation Regulation Of Telomere Maintenance Via Telomere Lengthening Translational Elongation
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