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PRRX1 and TNFRSF4
PRRX1
TNFRSF4
Description
paired related homeobox 1
TNF receptor superfamily member 4
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytosol
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Protein Binding
RNA Polymerase II General Transcription Initiation Factor Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
HMG Box Domain Binding
Virus Receptor Activity
Tumor Necrosis Factor Receptor Activity
Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Mesenchymal Cell Proliferation
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Smoothened Signaling Pathway
Mesenchymal Cell Proliferation
Embryonic Limb Morphogenesis
Inner Ear Morphogenesis
Middle Ear Morphogenesis
Positive Regulation Of Smoothened Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Neuron Fate Determination
Embryonic Cranial Skeleton Morphogenesis
Embryonic Skeletal System Morphogenesis
Artery Morphogenesis
Cartilage Development
Roof Of Mouth Development
Regulation Of Neuron Projection Regeneration
Stem Cell Proliferation
Neuronal Stem Cell Population Maintenance
Positive Regulation Of Stem Cell Proliferation
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Immunoglobulin Production
Inflammatory Response
Immune Response
Positive Regulation Of B Cell Proliferation
Tumor Necrosis Factor-mediated Signaling Pathway
T Cell Proliferation
Symbiont Entry Into Host Cell
Pathways
TNFs bind their physiological receptors
Drugs
Diseases
GWAS
A body shape index (
34021172
)
Appendicular lean mass (
33097823
)
Atrial fibrillation (
22544366
29892015
29290336
28416822
28416818
)
Calcific aortic valve stenosis (
32141789
)
Central corneal thickness (
32528159
)
Early onset atrial fibrillation (
28460022
)
Emphysema imaging phenotypes (
26030696
)
Estimated glomerular filtration rate (
31152163
)
Heel bone mineral density (
28869591
30598549
)
Height (
31562340
)
Hip circumference adjusted for BMI (
34021172
28552196
25673412
)
Hip index (
34021172
)
Intraocular pressure (
29617998
)
Macular thickness (
30535121
)
Male-pattern baldness (
28196072
29146897
)
PR interval (
32439900
)
Prevalent atrial fibrillation (
28416818
)
Refractive error (
32231278
)
Response to angiotensin II receptor blocker therapy (
22566498
)
Systemic lupus erythematosus (
33536424
)
Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes (
28736931
)
Waist circumference adjusted for body mass index (
34021172
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
26426971
34021172
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Inflammatory bowel disease (
23128233
)
Interacting Genes
11 interacting genes:
ATP1B1
CINP
GTF2I
MAFF
MAFG
QSOX1
SAAL1
SOX10
SRF
SUOX
TNFRSF4
18 interacting genes:
BTG2
DHX38
H6PD
LUZP1
MAPK14
MLLT6
NAP1L5
NUFIP2
PRRX1
RC3H1
SIVA1
TNFRSF9
TNFSF4
TRAF1
TRAF2
TRAF3
TRAF4
TRAF5
Entrez ID
5396
7293
HPRD ID
01337
02636
Ensembl ID
ENSG00000116132
ENSG00000186827
Uniprot IDs
P54821
A0A8V8TQH5
P43489
PDB IDs
1D0A
2HEV
2HEY
6OGX
6OKM
6OKN
7YK4
8AG1
Enriched GO Terms of Interacting Partners
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DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Multicellular Organism Development
Chordate Embryonic Development
In Utero Embryonic Development
Embryo Development Ending In Birth Or Egg Hatching
DNA-binding Transcription Factor Activity
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Sequence-specific Double-stranded DNA Binding
Regulation Of Multicellular Organismal Process
Positive Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Negative Regulation Of DNA-templated Transcription
Regulation Of Epidermis Development
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Epidermal Cell Differentiation
Serum Response Element Binding
Sulfite Oxidase Activity
Protein Transport Into Plasma Membrane Raft
Regulation Of Multicellular Organismal Development
Negative Regulation Of RNA Metabolic Process
Bronchus Cartilage Development
Lung Smooth Muscle Development
Protein Transport Into Membrane Raft
DNA-templated Transcription
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Population Proliferation
Negative Regulation Of Transcription By RNA Polymerase II
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Flavin-dependent Sulfhydryl Oxidase Activity
Stem Cell Differentiation
Cellular Response To Progesterone Stimulus
Trachea Cartilage Development
Cardiac Vascular Smooth Muscle Cell Differentiation
Molybdenum Ion Binding
Positive Regulation Of Synoviocyte Proliferation
Positive Regulation Of Potassium Ion Import Across Plasma Membrane
Protein Localization To Plasma Membrane Raft
Positive Regulation Of Biosynthetic Process
RNA Polymerase II Transcription Regulator Complex
Molybdopterin Cofactor Binding
Tumor Necrosis Factor Receptor Binding
Thioesterase Binding
Tumor Necrosis Factor-mediated Signaling Pathway
Signaling Adaptor Activity
CD40 Receptor Complex
Regulation Of Canonical NF-kappaB Signal Transduction
Apoptotic Process
Programmed Cell Death
Cell Death
Ubiquitin Protein Ligase Binding
Regulation Of MRNA Metabolic Process
Tumor Necrosis Factor Receptor Superfamily Binding
Regulation Of DNA-binding Transcription Factor Activity
Regulation Of MRNA Stability
MRNA Stabilization
CD40 Signaling Pathway
Interleukin-17-mediated Signaling Pathway
Cytokine-mediated Signaling Pathway
Regulation Of RNA Stability
Cell Surface Receptor Signaling Pathway
Negative Regulation Of MRNA Catabolic Process
RNA Stabilization
Positive Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of RNA Catabolic Process
Protein Phosphatase Binding
Negative Regulation Of MRNA Metabolic Process
Cytoplasmic Side Of Plasma Membrane
Positive Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of T-helper Cell Differentiation
Regulation Of Immune Response
Post-transcriptional Regulation Of Gene Expression
Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Zinc Ion Binding
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of T Cell Cytokine Production
Ubiquitin Protein Ligase Activity
Negative Regulation Of Alpha-beta T Cell Differentiation
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Immune Response
Negative Regulation Of CD4-positive, Alpha-beta T Cell Activation
Regulation Of Immune System Process
Signal Transduction Involved In Regulation Of Gene Expression
Positive Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Cell Population Proliferation
Positive Regulation Of Interleukin-12 Production
Regulation Of T Cell Proliferation
TORC2 Complex Disassembly
Regulation Of T Cell Cytokine Production
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Tagcloud (Difference)
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Tagcloud (Intersection)
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