UBASH3A and TYR

		UBASH3A	TYR
Description		ubiquitin associated and SH3 domain containing A	tyrosinase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Extracellular Exosome	Cytoplasm Lysosome Golgi-associated Vesicle Membrane Melanosome Membrane Melanosome Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Monooxygenase Activity Tyrosinase Activity Copper Ion Binding Protein Binding Oxidoreductase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Regulation Of Cytokine Production Negative Regulation Of T Cell Receptor Signaling Pathway	Melanin Biosynthetic Process From Tyrosine Eye Pigment Biosynthetic Process Visual Perception Cell Population Proliferation Response To UV Response To Blue Light Response To Vitamin D Melanin Biosynthetic Process Pigmentation Thymus Development Response To CAMP
Pathways			Melanin biosynthesis Regulation of MITF-M-dependent genes involved in pigmentation
Drugs			NADH Azelaic acid Monobenzone Mimosine Hydroquinone Arbutin Hexylresorcinol
Diseases			Oculocutaneous albinism (OCA)
GWAS		Addison's disease ( 33574239) Asthma ( 32296059) Autoimmune traits (pleiotropy) ( 30572963) Celiac disease ( 22057235 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Diverticular disease ( 30177863) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte count ( 32888494) Medication use (thyroid preparations) ( 31015401) Primary sclerosing cholangitis ( 27992413) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Type 1 diabetes ( 18840781 30572963 25751624 21829393 19430480) Vitiligo ( 27723757 20410501)	Age-related hearing impairment ( 34108613) Age-related macular degeneration ( 23326517) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Basal cell carcinoma ( 33549134 27539887 31174203) Blond vs. brown/black hair color ( 30531825) Blue vs. green eyes ( 17952075) Brown vs. black hair color ( 30531825) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Cutaneous squamous cell carcinoma ( 27424798 32041948) Eye color ( 20585627) Eye color (brightness) ( 30664655) Fish- and plant-related diet ( 32066663) Freckles ( 17952075) Hair color ( 26926045 30664655 29662168) Intraocular pressure ( 29617998) Keratinocyte cancer (MTAG) ( 31174203) Low tan response ( 29739929) Macular thickness ( 30535121) Melanoma ( 19578364 21983787 24980573 28212542) Neurociticism ( 29500382) Nevus count or cutaneous melanoma ( 30429480 32341527) Non-melanoma skin cancer ( 29739929) Optic disc size ( 31809533) Skin pigmentation ( 31315583 30664655 17999355) Skin pigmentation traits ( 30166351) Skin sensitivity to sun ( 17952075) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Squamous cell carcinoma ( 31174203 26829030) Sunburns ( 23548203) Tanning ( 23548203 19340012) Vitiligo ( 22561518 20410501 27723757)
Interacting Genes		108 interacting genes: ARRDC1 ARRDC3 ATF6 BACE2 BCAR3 CBLB CBS CCDC33 CD3E COPS9 CUEDC1 CXXC5 DAZAP2 DDIT4L DISC1 DLG1 DLGAP4 DNM2 DTX3 EHMT2 FADS6 FAM83A FGFR1OP2 GFAP GOLGA6L9 HSP90AA1 HSP90B1 HSPD1 IKBKG ISY1-RAB43 KCNE1 KCTD1 KIAA0408 KPRP KRT14 KRT31 KRT32 KRT35 KRT39 KRT40 LCN2 LNX1 LZTS1 LZTS2 MAP3K7 MKRN1 MTIF2 N4BP3 NEUROD2 NSMF PDE7A PFDN2 PLEKHB2 PMEPA1 PNMA5 PRDM6 PRKN PSMC1 PSMC4 REL RNF216 RNF41 SF3B4 SH3RF1 SHISA6 SLA2 SLC37A1 SLC4A3 SNRNP48 SOS1 SOS2 SPMIP6 SPRY1 SPRY2 SPRYD7 STX11 TAOK1 TAX1BP1 TEKT1 TEKT4 TIMM44 TMCO2 TMEM239 TP53BP2 TP63 TRIM27 TRIM37 TRIM5 TRIM50 TRIM8 TUBB8 TYR UBB UBC UBE2L3 VCP VPS37B VPS72 WAS WASL WBP11 YPEL3 ZBTB42 ZC2HC1C ZIC3 ZNF219 ZNF474 ZRANB1	3 interacting genes: PRICKLE1 TYRP1 UBASH3A
Entrez ID		53347	7299
HPRD ID		06904	06086
Ensembl ID		ENSG00000160185	ENSG00000077498
Uniprot IDs		P57075	L8B082 P14679
PDB IDs		2CRN 5WDI	7RK7
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Inclusion Body Assembly Post-translational Protein Modification Ubiquitin Protein Ligase Activity Intermediate Filament Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Identical Protein Binding Aggresome Assembly Proteolysis Involved In Protein Catabolic Process Morphogenesis Of An Epithelium Positive Regulation Of Catabolic Process Sperm Plasma Membrane WW Domain Binding Protein Binding Regulation Of Post-translational Protein Modification Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Keratin Filament Canonical NF-kappaB Signal Transduction Negative Regulation Of Membrane Tubulation Cytosol Cytoskeleton Organization Tissue Morphogenesis Positive Regulation Of Protein Catabolic Process Organelle Organization Modification-dependent Protein Catabolic Process Intermediate Filament Protein Polyubiquitination Macromolecule Catabolic Process Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Regulation Of Intracellular Signal Transduction SH3 Domain Binding P53 Binding Protein Localization To Mitochondrion Linear Polyubiquitin Binding Regulation Of Protein Catabolic Process Protein Polymerization Regulation Of Autophagy Regulation Of Signal Transduction Suppression Of Viral Release By Host Positive Regulation Of Protein Metabolic Process Regulation Of Type I Interferon Production Positive Regulation Of Post-translational Protein Modification Ubiquitin-protein Transferase Activity	Acetoacetic Acid Metabolic Process Anterior Visceral Endoderm Cell Migration Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Polarized Secretion Of Basement Membrane Proteins In Epithelium Cell Trailing Edge Tyrosinase Activity Establishment Of Bipolar Cell Polarity Involved In Cell Morphogenesis Focal Adhesion Disassembly Extracellular Matrix Constituent Secretion Tear Secretion Embryonic Nail Plate Morphogenesis Maintenance Of Postsynaptic Density Structure Ketone Body Metabolic Process Positive Regulation Of Melanin Biosynthetic Process Maintenance Of Postsynaptic Specialization Structure Cornea Development In Camera-type Eye Melanin Metabolic Process Regulation Of Melanin Biosynthetic Process Melanin Biosynthetic Process Primitive Streak Formation Eyelid Development In Camera-type Eye Negative Regulation Of Cardiocyte Differentiation Melanocyte Differentiation Short-chain Fatty Acid Metabolic Process Bounding Membrane Of Organelle Intracellular Vesicle Post-anal Tail Morphogenesis Embryonic Brain Development Regulation Of Postsynaptic Specialization Assembly Regulation Of Postsynaptic Density Assembly Regulation Of Excitatory Synapse Assembly Postsynaptic Density Organization Pigment Cell Differentiation Melanosome Membrane Postsynaptic Specialization Organization Negative Regulation Of Stem Cell Differentiation Renal Tubule Development Coronary Vasculature Development Negative Regulation Of T Cell Receptor Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Maintenance Of Synapse Structure Aorta Development Extracellular Matrix Assembly Basement Membrane Organization Negative Regulation Of Myoblast Differentiation Face Morphogenesis Melanosome Organization Pigment Granule Organization Response To Electrical Stimulus Cardiac Muscle Cell Development
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