MRPS23 and BRIP1

		MRPS23	BRIP1
Description		mitochondrial ribosomal protein S23	BRCA1 interacting DNA helicase 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Small Ribosomal Subunit Ribosome Nuclear Membrane Ribonucleoprotein Complex	Nucleus Nucleoplasm Replication Fork Cytoplasm Nuclear Membrane BRCA1-B Complex
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding	Nucleotide Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides Isomerase Activity ATP Hydrolysis Activity 5'-3' DNA Helicase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding Catalytic Activity, Acting On A Nucleic Acid
	Biological Process	Translation Mitochondrial Translation	DNA Damage Checkpoint Signaling Nucleobase-containing Compound Metabolic Process DNA Repair Nucleotide-excision Repair Double-strand Break Repair Regulation Of Transcription By RNA Polymerase II DNA Damage Response Homologous Chromosome Pairing At Meiosis Spermatogenesis Spermatogonial Cell Division Spermatid Development Male Gonad Development Meiotic DNA Double-strand Break Processing Involved In Reciprocal Meiotic Recombination Homologous Recombination Interstrand Cross-link Repair Chiasma Assembly Seminiferous Tubule Development Protein-DNA Covalent Cross-linking Repair Double-strand Break Repair Involved In Meiotic Recombination
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control	Cytosolic iron-sulfur cluster assembly HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs
Diseases			Fanconi anemia
GWAS		Ferritin levels ( 33491795) Obstetric antiphospholipid syndrome ( 28424481)	Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Ovarian cancer ( 21964575) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		7 interacting genes: BRIP1 GSC2 HSPB1 POLR1C PTEN UBC USHBP1	14 interacting genes: BLM BRCA1 CREBBP FANCD2 HDAC3 HNRNPC HPN HSD17B14 MRPS23 PATZ1 PECAM1 RPA1 SIRT1 TOPBP1
Entrez ID		51649	83990
HPRD ID		17592	05797
Ensembl ID		ENSG00000181610	ENSG00000136492
Uniprot IDs		Q9Y3D9	A0A804HJU1 A0A804HL36 J3QKX0 Q9BX63
PDB IDs		3J9M 6NU2 6NU3 6RW4 6RW5 6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7A5F 7A5G 7A5I 7A5K 7L08 7OG4 7P2E 7PNX 7PNY 7PNZ 7PO0 7PO1 7PO2 7PO3 7QI4 7QI5 7QI6 8ANY 8CSP 8CSQ 8CSR 8CSS 8CST 8CSU 8K2A 8OIR 8OIS 8QRK 8QRL 8QRM 8QRN 8RRI 8XT0 8XT2	1T15 1T29 3AL3
Enriched GO Terms of Interacting Partners?			Recombinational Repair Double-strand Break Repair Double-strand Break Repair Via Homologous Recombination DNA Repair Response To Ionizing Radiation Male Germ Cell Nucleus Lateral Element Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling P53 Binding DNA Metabolic Process Response To Radiation DNA Recombination DNA Damage Response DNA Damage Checkpoint Signaling Regulation Of Mitotic Cell Cycle PML Body Chromatin Organization Negative Regulation Of Cell Cycle Process Mitotic G2 DNA Damage Checkpoint Signaling Condensed Chromosome BRCA1-B Complex Nucleic Acid Metabolic Process Signal Transduction In Response To DNA Damage Negative Regulation Of Cell Cycle Condensed Nuclear Chromosome Cellular Response To Radiation Cellular Response To Stress Mitotic G2/M Transition Checkpoint Nucleoplasm Damaged DNA Binding Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Phase Transition Cellular Response To Ionizing Radiation Deacetylase Activity Regulation Of DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Random Inactivation Of X Chromosome Peptidyl-lysine Acetylation Protein Deacetylation Protein Lysine Deacetylase Activity DNA Repair Complex Regulation Of Cellular Response To Heat Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin-protein Adaptor Activity Histone Deacetylase Activity Regulation Of Cell Cycle
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