NUP98 and HBE1

		NUP98	HBE1
Description		nucleoporin 98 and 96 precursor	hemoglobin subunit epsilon 1
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GO Annotations	Cellular Component	Kinetochore Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytosol Membrane Nuclear Body Nuclear Pore Outer Ring Nuclear Membrane Nuclear Periphery Nuclear Inclusion Body Nuclear Pore Cytoplasmic Filaments Nuclear Pore Nuclear Basket Ribonucleoprotein Complex	Cytosol Hemoglobin Complex Haptoglobin-hemoglobin Complex Blood Microparticle
	Molecular Function	Transcription Coactivator Activity RNA Binding MRNA Binding Protein Binding Nuclear Localization Sequence Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Structural Constituent Of Nuclear Pore Peptide Binding Molecular Condensate Scaffold Activity Promoter-specific Chromatin Binding	Oxygen Carrier Activity Protein Binding Oxygen Binding Heme Binding Hemoglobin Alpha Binding Metal Ion Binding
	Biological Process	Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery RNA Export From Nucleus Proteolysis Protein Import Into Nucleus Nucleocytoplasmic Transport Nuclear Pore Organization Protein Transport Telomere Tethering At Nuclear Periphery Positive Regulation Of DNA-templated Transcription Positive Regulation Of MRNA Splicing, Via Spliceosome MRNA Transport Nuclear Pore Complex Assembly	Carbon Dioxide Transport Oxygen Transport Erythrocyte Development
Pathways			Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Malaria ( 31844061) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736)	Beta thalassemia/hemoglobin E disease ( 20183929) Hematology traits ( 23263863) Hemoglobin ( 28548082) Hemoglobin levels ( 26366553) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Logical memory (delayed recall) in normal cognition ( 29274321) Logical memory (immediate recall) in normal cognition ( 29274321) Malaria ( 31844061) Mean corpuscular hemoglobin concentration ( 28453575 23263863) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		31 interacting genes: APC CBFA2T3 CHMP5 CREBBP CSNK2A1 CYFIP1 EP300 HBE1 HDAC1 IPO5 KCNQ1 KPNB1 MUC2 NUP133 NUP188 NUP205 NUP214 NUP62 NUP88 NXF1 PSMD13 RAE1 RCC1 RNH1 RRM1 SEC13 SLC67A1-AS TNPO1 TNPO2 TPR UTRN	6 interacting genes: HBA1 HBA2 HBM HBQ1 HBZ NUP98
Entrez ID		4928	3046
HPRD ID		03012	00788
Ensembl ID		ENSG00000110713	ENSG00000213931
Uniprot IDs		A0A8V8TR21 H0YCR0 H0YEN4 P52948	D9YZU7 P02100
PDB IDs		1KO6 2Q5X 2Q5Y 3MMY 4OWR 5A9Q 6BZM 7F60 7F90 7MNI 7PEQ 7Q64 7Q65 7Q66 7Q67 7VPG 7VPH 8CI8	1A9W
Enriched GO Terms of Interacting Partners?		Nuclear Pore Nuclear Transport Nucleocytoplasmic Transport Protein Import Into Nucleus Import Into Nucleus Nuclear Envelope RNA Transport Structural Constituent Of Nuclear Pore Protein Localization To Nucleus MRNA Transport Nucleobase-containing Compound Transport Establishment Of Protein Localization To Organelle RNA Export From Nucleus Protein Localization To Organelle Intracellular Transport Nuclear Export Intracellular Protein Transport Protein Transport Nuclear Localization Sequence Binding Cellular Localization Establishment Of Protein Localization Establishment Of Localization In Cell MRNA Export From Nucleus Intracellular Protein Localization Regulation Of Mitotic Spindle Organization Nuclear Import Signal Receptor Activity Regulation Of Microtubule Cytoskeleton Organization Nucleoplasm Cytosol Nuclear Pore Organization Histone H3K27 Acetyltransferase Activity Regulation Of Cytoskeleton Organization Nucleus Regulation Of Microtubule-based Process Nuclear Membrane Regulation Of Mitotic Spindle Assembly Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Nuclear Pore Inner Ring Small GTPase Binding Regulation Of Cell Cycle Kinetochore Ribosomal Protein Import Into Nucleus RNA Import Into Nucleus Nucleus Organization Regulation Of Spindle Assembly Positive Regulation Of Protein Localization To Nucleus Regulation Of Cell Cycle Process Positive Regulation Of Protein Import Into Nucleus	Hemoglobin Complex Haptoglobin-hemoglobin Complex Oxygen Carrier Activity Oxygen Transport Oxygen Binding Erythrocyte Development Myeloid Cell Development Heme Binding Hemopoiesis Carbon Dioxide Transport Iron Ion Binding One-carbon Compound Transport Haptoglobin Binding Nitric Oxide Transport Cell Development Endocytic Vesicle Lumen Hydrogen Peroxide Catabolic Process Peroxidase Activity Hydrogen Peroxide Metabolic Process G Protein-coupled Receptor Binding Cellular Oxidant Detoxification Telomere Tethering At Nuclear Periphery Reactive Oxygen Species Metabolic Process Response To Hydrogen Peroxide Cellular Detoxification Cellular Developmental Process Blood Microparticle Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Response To Reactive Oxygen Species Nuclear Pore Cytoplasmic Filaments Metal Ion Binding Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Telomere Localization Nuclear Pore Outer Ring Nuclear Pore Complex Assembly Nuclear Inclusion Body Nuclear Pore Nuclear Basket Nuclear Pore Organization Nuclear Periphery Response To Oxidative Stress Erythrocyte Maturation Pore Complex Assembly Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore Developmental Process Peptide Binding Positive Regulation Of MRNA Splicing, Via Spliceosome Inflammatory Response Positive Regulation Of RNA Splicing
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