MYO9A and COL15A1

		MYO9A	COL15A1
Description		myosin IXA	collagen type XV alpha 1 chain
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Actin Filament Membrane Myosin Complex Unconventional Myosin Complex Growth Cone Cell Projection Axonal Growth Cone Synapse	Extracellular Region Collagen Trimer Collagen Type XV Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding GTPase Activator Activity Protein Binding ATP Binding Zinc Ion Binding Metal Ion Binding Actin Filament Binding	Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Signal Transduction Visual Perception Cell Junction Assembly Cell Junction Organization Intracellular Signal Transduction Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Neuron Projection Arborization	Angiogenesis Cell Adhesion Signal Transduction Cell Differentiation
Pathways		RHOA GTPase cycle RHOB GTPase cycle RHOV GTPase cycle	Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Collagen chain trimerization
Drugs
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 20881960) Macular thickness ( 30535121) Metabolite levels (HVA/MHPG ratio) ( 23319000) Rate of cognitive decline in mild cognitive impairment (time interaction) ( 22833209) Red blood cell count ( 27863252) Serum uric acid levels ( 30993211) Triglyceride levels ( 30108155 32203549) Urate levels ( 31578528)	Advanced age-related macular degeneration ( 26691988) Appendicular lean mass ( 33097823) Asthma ( 32296059 31959851) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease ( 30804561) Epithelial ovarian cancer ( 25134534) Fractures (paediatric) ( 32742401) Gut microbiota alpha diversity (Shannon index) ( 33208821) Gut microbiota relative abundance (unclassified genus belonging to the order Clostridiales) ( 33208821) Height ( 28552196) Lateral ventricle temporal horn volume ( 31530798) Pulse pressure ( 30224653 30578418) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: CDC42 COL15A1 ERBB2 MTNR1A POLR2M RHOA	6 interacting genes: GAS1 GOLGA5 GTF2IRD1 MYO9A PDGFB PIGO
Entrez ID		4649	1306
HPRD ID		05341	00380
Ensembl ID		ENSG00000066933	ENSG00000204291
Uniprot IDs		B2RTY4	B3KTP7 P39059
PDB IDs			3N3F
Enriched GO Terms of Interacting Partners?		Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Establishment Of Epithelial Cell Apical/basal Polarity Establishment Of Epithelial Cell Polarity Wnt Signaling Pathway, Planar Cell Polarity Pathway Substantia Nigra Development Establishment Or Maintenance Of Apical/basal Cell Polarity Semaphorin-plexin Signaling Pathway Positive Regulation Of Stress Fiber Assembly Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Cytokinesis Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Actin Filament Bundle Assembly Neural Nucleus Development G Protein Activity Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Cell Junction Organization Mitotic Cleavage Furrow Formation Regulation Of Cytokinesis Collagen Type XV Trimer Maintenance Of ER Location Positive Regulation Of Cell Division Establishment Of Cell Polarity Cell Periphery Positive Regulation Of Cell Adhesion Regulation Of Stress Fiber Assembly Ruffle Membrane Aortic Valve Formation Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Glial Cell Differentiation Skeletal Muscle Satellite Cell Migration GBD Domain Binding Storage Vacuole ERBB3:ERBB2 Complex Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Striated Muscle Tissue Development Positive Regulation Of Kinase Activity Beta Selection Endothelin Receptor Signaling Pathway Involved In Heart Process RNA Polymerase I Core Binding Muscle Tissue Development Bone Trabecula Morphogenesis Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Cell Growth	Positive Regulation Of Metanephric Mesenchymal Cell Migration Cellular Response To Mycophenolic Acid Metanephric Glomerular Mesangial Cell Development Platelet-derived Growth Factor Complex Positive Regulation Of Glomerular Filtration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Negative Regulation Of Phosphatidylinositol Biosynthetic Process Positive Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Transition Between Slow And Fast Fiber Mannose-ethanolamine Phosphotransferase Activity Glomerular Mesangial Cell Development Unconventional Myosin Complex Smooth Muscle Adaptation Negative Regulation Of Phospholipid Biosynthetic Process Regulation Of Hyaluronan Biosynthetic Process Mesangial Cell Development Positive Regulation Of Glomerular Mesangial Cell Proliferation Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Positive Regulation Of Protein Autophosphorylation Paracrine Signaling Cellular Response To Growth Factor Stimulus Regulation Of ER To Golgi Vesicle-mediated Transport Platelet-derived Growth Factor Binding Regulation Of Glomerular Mesangial Cell Proliferation Platelet-derived Growth Factor Receptor-beta Signaling Pathway Superoxide-generating NADPH Oxidase Activator Activity Positive Regulation Of Cell Proliferation Involved In Kidney Development Regulation Of Glomerular Filtration Regulation Of Skeletal Muscle Adaptation Golgi Cisterna Retrograde Transport, Vesicle Recycling Within Golgi Phosphotransferase Activity, For Other Substituted Phosphate Groups Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
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